Environment International,
Год журнала:
2024,
Номер
187, С. 108724 - 108724
Опубликована: Май 1, 2024
The
mass
concentration
of
atmospheric
particulate
matter
(PM)
has
been
continuously
decreasing
in
the
Beijing-Tianjin-Hebei
region.
However,
health
endpoints
do
not
exhibit
a
linear
correlation
with
PM
concentrations.
Thus,
it
is
urgent
to
clarify
prior
toxicological
components
further
improve
air
quality.
In
this
study,
we
analyzed
long-term
oxidative
potential
(OP)
water-soluble
PM2.5,
which
generally
considered
more
effective
assessing
hazardous
exposure
Beijing
from
2018
2022
based
on
dithiothreitol
assay
and
identified
crucial
drivers
OP
PM2.5
online
monitoring
pollutants,
receptor
model,
random
forest
(RF)
model.
Our
results
indicate
that
dust,
traffic,
biomass
combustion
are
main
sources
Beijing.
complex
interactions
dust
particles,
black
carbon,
gaseous
pollutants
(nitrogen
dioxide
sulfur
dioxide)
factors
driving
evolution,
particular,
leading
abnormal
rise
2022.
data
shows
higher
observed
winter
spring
compared
summer
autumn.
diurnal
variation
characterized
by
declining
trend
0:00
14:00
an
increasing
23:00.
spatial
was
as
lower
than
Shijiazhuang,
while
Zhenjiang
Haikou,
primarily
influenced
distribution
carbon.
significance
identifying
key
influencing
provide
new
insights
for
advancing
quality
improvement
efforts
focus
safeguarding
human
Environmental Health and Preventive Medicine,
Год журнала:
2025,
Номер
30(0), С. 10 - 10
Опубликована: Янв. 1, 2025
Heavy
metals
are
significant
risk
factors
for
kidney
function.
Numerous
studies
have
shown
that
exposure
to
heavy
negatively
correlates
with
function
through
oxidative
stress
pathways,
and
serum
α-klotho
is
linked
stress.
However,
the
role
of
in
relationship
between
blood
lead,
mercury,
remains
unclear.
This
study
evaluated
mediating
alpha-klotho
mercury
renal
function,
using
data
from
2007-2016
National
Health
Nutrition
Examination
Survey
(NHANES)
U.S.
adults
aged
40-79.
The
sample
included
11,032
participants,
α-klotho,
other
relevant
covariates
measured.
Inductively
coupled
plasma
mass
spectrometry
was
used
assess
lead
levels,
enzyme-linked
immunosorbent
assay
(ELISA)
employed
measure
α-klotho.
Kidney
estimated
glomerular
filtration
rate
(eGFR)
based
on
creatinine
levels.
Multivariable
linear
regression
conducted
analyze
relationships
eGFR.
A
mediation
analysis
model
whether
influenced
these
associations.
We
observed
a
association
Mediation
revealed
accounted
12.76%
eGFR
NHANES
population.
Subgroup
showed
mediated
12.43%,
6.87%,
21.50%
5.44%
women,
middle-aged
(40-59
years
old),
without
cardiovascular
disease
hypertension,
respectively.
did
not
mediate
terms
gender
or
age.
newly
identified
pathway
may
provide
valuable
insights
prevention
treatment
mechanisms
related
impairment.
found
associated
According
results
subgroup
analysis,
females,
middle
60-79
years.
clinically
significant,
α-Klotho
clinical
significance.
Environment International,
Год журнала:
2023,
Номер
178, С. 108087 - 108087
Опубликована: Июль 5, 2023
Perfluoroalkyl
acids
(PFAAs)
within
the
broader
class
of
per-
and
polyfluoroalkyl
substances
(PFAS)
are
present
in
human
serum
as
isomer
mixtures,
but
epidemiological
studies
have
yet
to
address
isomer-specific
associations
with
child
development
behavior.To
examine
between
prenatal
exposure
25
PFAAs,
including
perfluorooctane
sulfonate
(PFOS)
perfluorooctanoate
(PFOA)
isomers,
neurodevelopment
among
490
mother-child
pairs
a
prospective
Canadian
birth
cohort,
Alberta
Pregnancy
Outcomes
Nutrition
(APrON)
study.
To
consider
influence
classic
neurotoxicant,
total
mercury
(THg),
based
on
its
likelihood
co-exposure
PFAAs
from
common
dietary
sources.Maternal
blood
samples
were
collected
second
trimester
was
assessed
at
2
years
age
using
Bayley
Scales
Infant
Toddler
Development,
3rd
Edition
(Bayley-III).
Linear
or
curvilinear
multiple
regression
models
used
exposures
outcomes.Select
associated
lower
Cognitive
composite
scores,
perfluoroheptanoate
(PFHpA)
(β
=
-0.88,
95%
confidence
interval
(CI):
-1.7,
-0.06)
perfluorododecanoate
(PFDoA)
-2.0,
CI:
-3.9,
-0.01).
Non-linear
relationships
revealed
PFOS
-4.4,
-8.3,
-0.43),
linear-PFOS
-4.0,
-7.5,
-0.57)
1m-PFOS
-1.8,
-3.3,
-0.24)
isomers
Language
scores.
Although
there
no
effect
modification,
THg
interaction
terms
PFAA
negative
perfluorononanoate
(PFNA)
Motor
-6.2,
-0.33)
Social-Emotional
-3.0,
-5.6,
-0.40)
scores.These
findings
reinforce
previous
reports
adverse
effects
maternal
during
pregnancy
neurodevelopment.
The
unique
hazards
posed
justify
analysis
future
studies.
control
for
possible
confounding,
may
be
considered
PFAAs.
Toxics,
Год журнала:
2025,
Номер
13(1), С. 55 - 55
Опубликована: Янв. 14, 2025
Background:
While
current
epidemiological
studies
have
documented
associations
between
environmental
metals
and
renal
dysfunction,
the
majority
concentrated
on
plasma
metal
levels.
The
relationship
urinary
exposure
chronic
kidney
disease
(CKD)
remains
contentious,
particularly
within
specific
demographic
groups.
Methods:
This
cross-sectional
study
included
2919
rural
Chinese
adults
recruited
2018
2019.
Urine
were
measured
by
ICP-MS.
Least
absolute
shrinkage
selection
operator
(LASSO)
regression
was
employed
to
identify
significantly
associated
with
CKD.
Then,
we
used
binary
logistic
regression,
along
restricted
cubic
spline
(RCS)
models,
assess
individual
effects
of
Quantile
g-computation,
weighted
quantile
sum
Bayesian
kernel
machine
(BKMR)
models
applied
evaluate
combined
exposures
Gender-stratified
analyses
also
conducted
explore
these
associations.
Results:
LASSO
identified
seven
(V,
Cu,
Rb,
Sr,
Ba,
W,
Pb)
significant
impacts
In
single-metal
Cu
W
exhibited
a
positive
correlation
CKD,
whereas
V,
Pb
showed
negative
correlations
(all
p
<
0.05).
RCS
analysis
revealed
nonlinear
Pb,
CKD
p-nonlinear
multi-metal
model,
quantile-based
g-computation
demonstrated
collective
association
risk
for
mixed
(OR
(95%
CI)
=
−0.430
(−0.656,
−0.204);
0.001),
contributing
this
effect.
WQS
model
further
confirmed
joint
CI):
−0.885
(−1.083,
−0.899);
V
as
main
contributor.
BKMR
indicated
an
overall
impact
mixture
risk.
Interactions
may
exist
well
Sr
Pb.
female
subgroup
in
consistency
association.
Conclusions:
Our
findings
demonstrate
risk,
notable
females.
Joint
multiple
involve
synergistic
or
antagonistic
interactions
influencing
function.
Further
research
is
needed
validate
observations
elucidate
underlying
mechanisms.
