Environmental Advances,
Год журнала:
2023,
Номер
12, С. 100372 - 100372
Опубликована: Апрель 30, 2023
Microplastics
are
pollutants
of
serious
environmental
and
public
health
concern.
Although
predominantly
known
to
occur
in
biological
matrices,
emerging
scientific
evidence
has
indicated
that
they
can
also
fecal
matter.
Animal
manure,
both
raw
treated,
is
usually
applied
on
farmlands
as
organic
fertilizer,
serving
an
entry
point
microplastic
particles
into
agricultural
soil.
The
present
study
analyzes
the
literature
occurrence
microplastics
(sources
analytical
methods
detection
livestock
poultry
manure),
their
toxicodynamic,
toxicokinetics
endpoints
farm
animals.
Based
studies
examined
herein,
there
a
lack
harmonization
sampling,
digestion,
extraction
procedures
for
animal
manure.
abundance
was
9.02
×
102
±
1.29
103
particles/kg-1
pig,
7.40
101
cow,
0
5000
particles/kg−1
sheep,
129.8
82.3
particles/g−1
(0.1298
particles/kg)
chicken
have
been
found
manure
were
primarily
ingested
from
microplastics-contaminated
feed
plastic
mulching
film
attached
crop
residues.
However,
other
likely
sources
(e.g.,
water,
soil,
air)
need
be
studied
carefully.
Despite
limited
fate
weight
currently
available
shows
exhibit
different
characteristics
during
treatment
previous
all
based
composting
experiments.
Therefore,
research
required
profound
sense
better
understanding
influence
physicochemical
properties
(shape,
size,
type,
composition)
treatment.
Moreover,
exposure
animals
revealed
several
toxicological
effects
but
more
needed
clearly
understand
dose-response
relationship,
absorption,
distribution,
metabolism,
elimination
mechanisms
with
respect
factors
(microplastic
sizes,
shapes,
polymers,
types
additive,
co-contaminants).
Environmental Chemistry Letters,
Год журнала:
2023,
Номер
21(4), С. 2129 - 2169
Опубликована: Апрель 4, 2023
Abstract
Microplastic
pollution
is
becoming
a
major
issue
for
human
health
due
to
the
recent
discovery
of
microplastics
in
most
ecosystems.
Here,
we
review
sources,
formation,
occurrence,
toxicity
and
remediation
methods
microplastics.
We
distinguish
ocean-based
land-based
sources
Microplastics
have
been
found
biological
samples
such
as
faeces,
sputum,
saliva,
blood
placenta.
Cancer,
intestinal,
pulmonary,
cardiovascular,
infectious
inflammatory
diseases
are
induced
or
mediated
by
exposure
during
pregnancy
maternal
period
also
discussed.
Remediation
include
coagulation,
membrane
bioreactors,
sand
filtration,
adsorption,
photocatalytic
degradation,
electrocoagulation
magnetic
separation.
Control
strategies
comprise
reducing
plastic
usage,
behavioural
change,
using
biodegradable
plastics.
Global
production
has
risen
dramatically
over
past
70
years
reach
359
million
tonnes.
China
world's
top
producer,
contributing
17.5%
global
production,
while
Turkey
generates
waste
Mediterranean
region,
at
144
tonnes
per
day.
75%
marine
waste,
with
responsible
80–90%
pollution,
account
only
10–20%.
induce
toxic
effects
on
humans
animals,
cytotoxicity,
immune
response,
oxidative
stress,
barrier
attributes,
genotoxicity,
even
minimal
dosages
10
μg/mL.
Ingestion
animals
results
alterations
gastrointestinal
tract
physiology,
system
depression,
differential
gene
expression,
growth
inhibition.
Furthermore,
bioaccumulation
tissues
aquatic
organisms
can
adverse
ecosystem,
potential
transmission
birds.
Changing
individual
behaviours
governmental
actions,
implementing
bans,
taxes,
pricing
carrier
bags,
significantly
reduced
consumption
8–85%
various
countries
worldwide.
The
microplastic
minimisation
approach
follows
an
upside-down
pyramid,
starting
prevention,
followed
reducing,
reusing,
recycling,
recovering,
ending
disposal
least
preferable
option.
Environment International,
Год журнала:
2022,
Номер
171, С. 107662 - 107662
Опубликована: Ноя. 26, 2022
Exposure
to
micro-
and
nanoplastics
(MNPs)
is
inevitable
due
their
omnipresence
in
the
environment.
A
growing
body
of
studies
has
advanced
our
understanding
potential
toxicity
MNPs
but
knowledge
gaps
still
exist
regarding
adverse
effects
on
cardiovascular
system
underlying
mechanisms,
particularly
humans.
Here,
we
reviewed
up-to-date
data
published
past
10
years
MNP-driven
mechanisms.
Forty-six
articles
concerning
ADME
(absorption,
distribution,
aggregation
behaviors)
circulatory
animals
human
cells
were
analyzed
summarized.
The
results
showed
that
affected
cardiac
functions
caused
(micro)vascular
sites.
Direct
included
abnormal
heart
rate,
function
impairment,
pericardial
edema,
myocardial
fibrosis.
On
sites,
induced
hemolysis,
thrombosis,
blood
coagulation,
vascular
endothelial
damage.
main
mechanisms
oxidative
stress,
inflammation,
apoptosis,
pyroptosis,
interaction
between
multiple
cellular
components.
Cardiovascular
was
determined
by
properties
(type,
size,
surface,
structure)
MNPs,
exposure
dose
duration,
protein
presence,
life
stage,
sex,
species
tested
organisms,
as
well
with
other
environmental
contamination.
limited
quantitative
information
MNPs'
lack
guidelines
for
MNP
cardiotoxicity
testing
makes
risk
assessment
health
impossible.
Furthermore,
future
directions
research
are
recommended
enable
more
realistic
assessment.
EBioMedicine,
Год журнала:
2023,
Номер
99, С. 104901 - 104901
Опубликована: Дек. 6, 2023
Humans
are
exposed
to
micro-and-nano
plastics
(MNPs)
through
various
routes,
but
the
adverse
health
effects
of
MNPs
on
different
organ
systems
not
yet
fully
understood.
This
review
aims
provide
an
overview
potential
impacts
and
identify
knowledge
gaps
in
current
research.
The
summarized
results
suggest
that
exposure
can
lead
oxidative
stress,
inflammation,
immune
dysfunction,
altered
biochemical
energy
metabolism,
impaired
cell
proliferation,
disrupted
microbial
metabolic
pathways,
abnormal
development,
carcinogenicity.
There
is
limited
human
data
MNPs,
despite
evidence
from
animal
cellular
studies.
Most
published
research
has
focused
specific
types
assess
their
toxicity,
while
other
plastic
particles
commonly
found
environment
remain
unstudied.
Future
studies
should
investigate
by
considering
realistic
concentrations,
dose-dependent
effects,
individual
susceptibility,
confounding
factors.
Environment International,
Год журнала:
2023,
Номер
179, С. 108171 - 108171
Опубликована: Авг. 25, 2023
Microplastic
particles
(MP)
are
prevalent
in
both
industrial
production
and
the
natural
environment,
posing
a
significant
concern
for
human
health.
Daily
diet,
air
inhalation,
skin
contact
major
routines
of
MP
intake
human.
The
main
injury
target
systems
MPs
include
digestive
system,
respiratory
cardiovascular
system.
However,
study
on
MPs'
adverse
effects
heart
is
less
than
other
organs.
Previous
vivo
studies
have
demonstrated
that
can
induce
injuries,
including
abnormal
rate,
apoptosis
cardiomyocytes,
mitochondrial
membrane
potential
change,
fibrin
overexpression.
To
address
animal
welfare
concerns
overcome
inter-species
variations,
this
employed
pluripotent
stem
cell-derived
vitro
three-dimensional
cardiac
organoid
(CO)
model
to
investigate
heart.
distinct
cavities
COs
allowed
observation
aggregation
spatial
distribution
following
polystyrene-MP
(PS)
exposure
dynamic
After
various
concentrations
PS
(0.025,
0.25
2.5
µg/mL,
with
lowest
concentration
equivalent
internal
levels),
exhibited
increased
oxidative
stress,
inflammatory
response,
apoptosis,
collagen
accumulation.
These
findings
were
consistent
observations,
terms
increases
interventricular
septal
thickness.
expression
hypertrophic-related
genes
(MYH7B/ANP/BNP/COL1A1)
changed
noticeably
cardiac-specific
markers
MYL2/MYL4/CX43
also
markedly
elevated.
Our
revealed
could
induced
hypertrophy
vitro,
indicating
may
be
an
under-recognized
risk
factor
