The possible impacts of nano and microplastics on human health: lessons from experimental models across multiple organs DOI

Bernardo Lannes Monteiro Fontes,

Lorena Cristina de Souza e Souza,

Ana Paula Santos da Silva de Oliveira

и другие.

Journal of Toxicology and Environmental Health Part B, Год журнала: 2024, Номер 27(4), С. 153 - 187

Опубликована: Март 22, 2024

The widespread production and use of plastics have resulted in accumulation plastic debris the environment, gradually breaking down into smaller particles over time. Nano-plastics (NPs) microplastics (MPs), defined as than 100 nanometers 5 millimeters, respectively, raise concerns due to their ability enter human body through various pathways including ingestion, inhalation, skin contact. Various investigators demonstrated that these may produce physical chemical damage cells, tissues, organs, disrupting cellular processes, triggering inflammation oxidative stress, impacting hormone neurotransmitter balance. In addition, micro- nano-plastics (MNPLs) carry toxic chemicals pathogens, exacerbating adverse effects on health. magnitude nature are not yet fully understood, requiring further research for a comprehensive risk assessment. Nevertheless, evidence available suggests environment potential uptake causes concern. Urgent measures reduce pollution limit exposure MNPLs necessary safeguard health environment. this review, current knowledge regarding influence is summarized, toxicity mechanisms, pathways, outcomes across multiple organs. critical need additional also emphasized comprehensively assess risks posed by degradation inform strategies addressing emerging environmental challenge. Finally, new directions proposed evaluation gene regulation associated with exposure.

Язык: Английский

Microplastics and Nanoplastics in Atheromas and Cardiovascular Events DOI
Raffaele Marfella, Francesco Prattichizzo, Celestino Sardu

и другие.

New England Journal of Medicine, Год журнала: 2024, Номер 390(10), С. 900 - 910

Опубликована: Март 6, 2024

Microplastics and nanoplastics (MNPs) are emerging as a potential risk factor for cardiovascular disease in preclinical studies. Direct evidence that this extends to humans is lacking.

Язык: Английский

Процитировано

381
The potential impacts of micro-and-nano plastics on various organ systems in humans DOI Creative Commons
Nurshad Ali,

Jenny Katsouli,

Emma L. Marczylo

и другие.

EBioMedicine, Год журнала: 2023, Номер 99, С. 104901 - 104901

Опубликована: Дек. 6, 2023

Humans are exposed to micro-and-nano plastics (MNPs) through various routes, but the adverse health effects of MNPs on different organ systems not yet fully understood. This review aims provide an overview potential impacts and identify knowledge gaps in current research. The summarized results suggest that exposure can lead oxidative stress, inflammation, immune dysfunction, altered biochemical energy metabolism, impaired cell proliferation, disrupted microbial metabolic pathways, abnormal development, carcinogenicity. There is limited human data MNPs, despite evidence from animal cellular studies. Most published research has focused specific types assess their toxicity, while other plastic particles commonly found environment remain unstudied. Future studies should investigate by considering realistic concentrations, dose-dependent effects, individual susceptibility, confounding factors.

Язык: Английский

Процитировано

134
Microplastics in three types of human arteries detected by pyrolysis-gas chromatography/mass spectrometry (Py-GC/MS) DOI
Sheng Liu, Chenyang Wang, Yunxiao Yang

и другие.

Journal of Hazardous Materials, Год журнала: 2024, Номер 469, С. 133855 - 133855

Опубликована: Фев. 21, 2024

Язык: Английский

Процитировано

78
Recent progress of microplastic toxicity on human exposure base on in vitro and in vivo studies DOI

Zhengguo Liu,

Xue‐yi You

The Science of The Total Environment, Год журнала: 2023, Номер 903, С. 166766 - 166766

Опубликована: Сен. 2, 2023

Язык: Английский

Процитировано

69
Low-dose of polystyrene microplastics induce cardiotoxicity in mice and human-originated cardiac organoids DOI Creative Commons
Yue Zhou, Qian Wu, Yan Li

и другие.

Environment International, Год журнала: 2023, Номер 179, С. 108171 - 108171

Опубликована: Авг. 25, 2023

Microplastic particles (MP) are prevalent in both industrial production and the natural environment, posing a significant concern for human health. Daily diet, air inhalation, skin contact major routines of MP intake human. The main injury target systems MPs include digestive system, respiratory cardiovascular system. However, study on MPs' adverse effects heart is less than other organs. Previous vivo studies have demonstrated that can induce injuries, including abnormal rate, apoptosis cardiomyocytes, mitochondrial membrane potential change, fibrin overexpression. To address animal welfare concerns overcome inter-species variations, this employed pluripotent stem cell-derived vitro three-dimensional cardiac organoid (CO) model to investigate heart. distinct cavities COs allowed observation aggregation spatial distribution following polystyrene-MP (PS) exposure dynamic After various concentrations PS (0.025, 0.25 2.5 µg/mL, with lowest concentration equivalent internal levels), exhibited increased oxidative stress, inflammatory response, apoptosis, collagen accumulation. These findings were consistent observations, terms increases interventricular septal thickness. expression hypertrophic-related genes (MYH7B/ANP/BNP/COL1A1) changed noticeably cardiac-specific markers MYL2/MYL4/CX43 also markedly elevated. Our revealed could induced hypertrophy vitro, indicating may be an under-recognized risk factor

Язык: Английский

Процитировано

53
Long‐Chain Acyl Carnitines Aggravate Polystyrene Nanoplastics‐Induced Atherosclerosis by Upregulating MARCO DOI Creative Commons
Bo Wang,

Boxuan Liang,

Yuji Huang

и другие.

Advanced Science, Год журнала: 2023, Номер 10(19)

Опубликована: Май 5, 2023

Abstract Exposure to micro‐ and nanoplastics (MNPs) is common because of their omnipresence in environment. Recent studies have revealed that MNPs may cause atherosclerosis, but the underlying mechanism remains unclear. To address this bottleneck, ApoE −/− mice are exposed 2.5–250 mg kg −1 polystyrene (PS‐NPs, 50 nm) by oral gavage with a high‐fat diet for 19 weeks. It found PS‐NPs blood aorta mouse exacerbate artery stiffness promote atherosclerotic plaque formation. activate phagocytosis M1‐macrophage aorta, manifesting as upregulation macrophage receptor collagenous structure (MARCO). Moreover, disrupt lipid metabolism increase long‐chain acyl carnitines (LCACs). LCAC accumulation attributed PS‐NP‐inhibited hepatic carnitine palmitoyltransferase 2. PS‐NPs, well LCACs alone, aggravate via upregulating MARCO oxidized low‐density lipoprotein‐activated foam cells. Finally, synergistic effects on increasing total cholesterol cells found. Overall, study indicates PS‐NP‐induced atherosclerosis MARCO. This offers new insight into mechanisms MNP‐induced cardiovascular toxicity, highlights combined endogenous metabolites system, which warrant further study.

Язык: Английский

Процитировано

44
Microplastics in human blood: Polymer types, concentrations and characterisation using μFTIR DOI Creative Commons
Sophie V. L. Leonard,

Catriona R. Liddle,

Charlotte A. Atherall

и другие.

Environment International, Год журнала: 2024, Номер 188, С. 108751 - 108751

Опубликована: Май 14, 2024

Microplastics (MPs) are an everyday part of life, and now ubiquitous in the environment. Crucially, MPs have not just been found within environment, but also human bodies, including blood. We aimed to provide novel information on range MP polymer types present, as well their size shape characteristics, whole blood from 20 healthy volunteers. Twenty-four were identified 18 out (90 %) donors quantified blood, with majority observed for first time. Using LOQ approach, five met threshold a lower mean ± SD 2466 4174 MP/L. The concentrations plastics analysed samples ranged 1.84 - 4.65 μg/mL. Polyethylene (32 %), ethylene propylene diene (14 ethylene-vinyl-acetate/alcohol (12 fragments most abundant. particles that had particle length 127.99 293.26 µm (7-3000 µm), width 57.88 88.89 (5-800 µm). predominantly categorised (88 white/clear (79 %). A variety plastic additive chemicals endocrine disrupting-classed phthalates. procedural blank comprised 7 types, distinct those mainly resin (25 polyethylene terephthalate (17 polystyrene 4.80 5.59 This study adds growing evidence taken up into body transported via bloodstream. sizes raise important questions respect presence associated hazards terms potential detrimental impacts such vascular inflammation, build major organs, changes either immune cell response, or haemostasis thrombosis.

Язык: Английский

Процитировано

43
Micro(nano)plastics in the Human Body: Sources, Occurrences, Fates, and Health Risks DOI
Penghui Li,

Jingfu Liu

Environmental Science & Technology, Год журнала: 2024, Номер unknown

Опубликована: Фев. 5, 2024

The increasing global attention on micro(nano)plastics (MNPs) is a result of their ubiquity in the water, air, soil, and biosphere, exposing humans to MNPs daily basis threatening human health. However, crucial data body, including sources, occurrences, behaviors, health risks, are limited, which greatly impedes any systematic assessment impact body. To further understand effects we must identify existing knowledge gaps that need be immediately addressed provide potential solutions these issues. Herein, examined current literature behaviors body as well risks. Furthermore, identified key resolved comprehensively assess Additionally, complexity lack efficient analytical methods main barriers impeding investigations necessitating development standard unified method. Finally, highlighted for interdisciplinary studies from environmental, biological, medical, chemical, computer, material scientists fill drive research. Considering inevitability occurrence exposure MNPs, more urgently required enhance our understanding negative

Язык: Английский

Процитировано

40
Microplastics in marine ecosystems: A comprehensive review of biological and ecological implications and its mitigation approach using nanotechnology for the sustainable environment DOI

Eswar Marcharla,

Saranya Vinayagam,

Lalitha Gnanasekaran

и другие.

Environmental Research, Год журнала: 2024, Номер 256, С. 119181 - 119181

Опубликована: Май 19, 2024

Язык: Английский

Процитировано

36
Multimodal detection and analysis of microplastics in human thrombi from multiple anatomically distinct sites DOI Creative Commons
Tingting Wang,

Zhiheng Yi,

Xiaoqiang Liu

и другие.

EBioMedicine, Год журнала: 2024, Номер 103, С. 105118 - 105118

Опубликована: Апрель 13, 2024

BackgroundMicroplastic (MP) pollution has emerged as a significant environmental concern worldwide. While extensive research focused on their presence in marine organisms and ecosystems, potential impact human health, particularly the circulatory system, remains understudied. This project aimed to identify quantify mass concentrations, polymer types, physical properties of MPs thrombi surgically retrieved from both arterial venous systems at three anatomically distinct sites, namely, cerebral arteries brain, coronary heart, deep veins lower extremities. Furthermore, this study investigate association between levels disease severity.MethodsThrombus samples were collected 30 patients who underwent thrombectomy procedures due ischaemic stroke (IS), myocardial infarction (MI), or vein thrombosis (DVT). Pyrolysis–gas chromatography spectrometry (Py-GC/MS) was employed concentrations MPs. Laser direct infrared (LDIR) spectroscopy scanning electron microscopy (SEM) used analyse Demographic clinical information also examined. A rigorous quality control system eliminate contamination.FindingsMPs detected by Py-GC/MS 80% (24/30) obtained with IS, MI, DVT, median 61.75 μg/g, 141.80 69.62 respectively. Among 10 target types MP polymers, polyamide 66 (PA66), polyvinyl chloride (PVC), polyethylene (PE) identified. Further analyses suggested that higher may be associated greater severity (adjusted β = 7.72, 95% CI: 2.01–13.43, p < 0.05). The level D-dimer MP-detected group significantly than MP-undetected (8.3 ± 1.5 μg/L vs 6.6 0.5 μg/L, 0.001). Additionally, LDIR analysis showed PE dominant among 15 identified MPs, accounting for 53.6% all mean diameter 35.6 μm. shapes polymers using SEM found heterogeneous.InterpretationThis presents qualitative quantitative evidence thrombotic diseases through use multimodal detection methods. Higher increased severity. Future larger sample size is urgently needed sources exposure validate observed trends study.FundingThis funded SUMC Scientific Research Initiation Grant (SRIG, No. 009-510858038), Postdoctoral (No. 202205230031-3), 2020 Li Ka Shing Foundation Cross-Disciplinary 2020LKSFG02C).

Язык: Английский

Процитировано

32