National Science Review,
Год журнала:
2024,
Номер
12(1)
Опубликована: Сен. 29, 2024
ABSTRACT
Carbon-14
(C-14)
has
been
a
major
contributor
to
the
human
radioactive
exposure
dose,
as
it
is
released
into
environment
from
nuclear
industry
in
larger
quantities
compared
other
radionuclides.
This
most
abundant
nuclide
enters
biosphere
organically
bound
C-14
(OBC-14),
posing
potential
threat
public
health.
Yet,
remains
unknown
how
this
relatively
low
radiotoxic
induces
health
risks
via
chemical
effects,
such
isotope
effect.
By
establishing
trophic
transfer
model
involving
algae
(Scenedesmus
obliquus),
daphnia
(Daphnia
magna)
and
zebrafish
(Danio
rerio),
we
demonstrate
that
rapid
incorporation
transformation
of
inorganic
by
OBC-14
facilitates
blending
biomolecules
zebrafish.
We
find
internalized
persistently
retained
brain
zebrafish,
affecting
DNA
methylation
causing
alterations
neuropathology.
Global
tracing
metabolomics
with
further
reveals
involvement
various
critical
metabolic
pathways,
including
one-carbon
metabolism
nucleotide
metabolism.
thus
characterize
kinetic
effects
for
12C/14C
key
reactions
these
pathways
through
experiments
density
functional
theory
computations,
showing
isotopic
substitution
carbon
biochemicals
regulates
disrupting
reaction
ratios
effects.
Our
results
suggest
discharged
can
be
biotransformed
impact
providing
new
insights
understanding
risk
C-14,
which
traditionally
considered
nuclide.
Catalysts,
Год журнала:
2024,
Номер
14(9), С. 620 - 620
Опубликована: Сен. 14, 2024
Water
from
Madín
Dam
in
Mexico
has
been
shown
to
contain
a
wide
variety
of
pollutants
such
as
drugs,
pesticides,
personal
care
products
and
compounds
that
are
released
into
the
environment
waste
production
processes.
In
this
work,
effect
main
process
variables
on
percentage
total
organic
carbon
(TOC)
removal
water
samples
reservoir
was
studied
by
applying
photo-Fenton
treatment
catalyzed
with
iron-pillared
clays.
The
catalyst
characterized
XRD,
N2
physisorption,
DRS
XPS.
sampling
characterization
carried
out
according
Mexican
standards.
system
for
tests
0.1
L
reaction
volume
controlled
temperature
23–25
°C,
kept
under
constant
stirring.
After
4
h
time
UV
light,
TOC
90%,
it
60%
Vis
light.
ROS
involved
driven
UVC
light
were
hydroxyl
radicals,
while
hydroperoxyl
radicals
predominate
Vis-light-driven
process.
Evidence
superoxide
anion
participation
not
found.
toxicity
untreated
treated
assessed
Danio
rerio
specimens,
observed
be
reduced
after
treatment.
Ecotoxicology and Environmental Safety,
Год журнала:
2023,
Номер
267, С. 115617 - 115617
Опубликована: Окт. 21, 2023
The
antidiabetic
pharmaceutical
metformin
(MET)
is
largely
unmetabolized
by
the
human
body.
Its
residues
are
readily
detectable
in
various
aquatic
environments
and
may
have
adverse
impacts
on
growth
survival
of
species.
To
date,
its
toxicological
effects
scarcely
been
explored
non-fish
Here,
we
exposed
tadpoles
black-spotted
pond
frog
(Pelophylax
nigromaculatus)
to
different
concentrations
(0,
1,
10
100
μg/L)
MET
for
30
days
measured
body
size,
intestinal
microbiota
metabolites
evaluate
potential
exposure
amphibian
larvae.
did
not
affect
microbial
diversity
tadpoles.
However,
composition
changed
significantly,
with
some
pathogenic
bacteria
(e.g.,
bacterial
genera
Salmonella,
Comamonas,
Stenotrophomonas,
Trichococcus)
increasing
beneficial
Blautia,
Prevotella)
decreasing
MET-exposed
levels
associated
immune
performance
also
significantly
following
exposure.
Overall,
our
results
indicated
that
MET,
even
at
environmentally
relevant
concentrations,
would
cause
dysbiosis
metabolite
alteration,
thereby
influencing
health
status
non-target
organisms,
such
as
amphibians.
