bioRxiv (Cold Spring Harbor Laboratory),
Год журнала:
2024,
Номер
unknown
Опубликована: Апрель 17, 2024
Abstract
Chemical
exposomes
can
now
be
comprehensively
measured
in
human
blood,
but
robust
application
of
chemical
exposomics
cohort
studies
requires
knowledge
the
longitudinal
stability
and
interindividual
variability
exogenous
molecular
profiles.
Here
we
applied
to
plasma
46
adults,
each
sampled
six
times
over
two
years
a
multiomic
wellness
cohort.
New
chemicals
were
discovered,
distinctive
co-exposure
patterns
observed,
intra-class
correlation
coefficients
(ICC)
for
519
confidently
annotated
substances
are
reported
support
study
design.
Longitudinal
exposome
(mean
ICC
0.30)
was
significantly
lower
than
proteome,
metabolome,
lipidome
or
microbiome,
must
more
frequently
other
profiles
health
studies.
Mixed-effects
models
nevertheless
revealed
significant
associations
between
testosterone
perfluoroalkyl
substances,
time-trends
low
high
exposures
alike.
Complex
data
structures
visualized
explored,
demonstrating
great
potential
precision
research.
Teaser
The
first
cohort-level
novel
dynamic
co-exposures
blood
relevance
health.
The Science of The Total Environment,
Год журнала:
2023,
Номер
905, С. 167080 - 167080
Опубликована: Сен. 16, 2023
Streams
and
their
riparian
areas
are
important
habitats
foraging
sites
for
bats
feeding
on
emergent
aquatic
insects.
Chemical
pollutants
entering
freshwater
streams
from
agricultural
wastewater
sources
have
been
shown
to
alter
insect
emergence,
yet
little
is
known
about
how
this
impacts
insectivorous
in
areas.
In
study,
we
investigate
the
relationships
between
presence
of
effluent,
in-stream
pesticide
toxicity,
number
flying
insects,
activity
hunting
behaviour
at
14
southwestern
Germany.
Stream
were
located
forests,
sheltered
direct
exposure
urban
We
focused
three
bat
species
associated
with
areas:
Myotis
daubentonii,
M.
cf.
brandtii,
Pipistrellus
pipistrellus.
found
that
higher
toxicity
more
frequent
detection
also
tended
be
warmer
nutrient
lower
oxygen
concentrations.
did
not
observe
a
reduction
or
rates
association
detections.
Instead,
spp.
polluted
sites.
The
observed
increase
suggests
instead
reduced
prey
availability,
chemical
pollution
levels
measured
present
study
could
expose
transported
stream
by
International Journal of Environment and Climate Change,
Год журнала:
2023,
Номер
13(11), С. 2509 - 2521
Опубликована: Ноя. 8, 2023
The
monitoring
of
the
organic
pollution
level
and
ecological
health
risks
waters
from
Déganobo
lake
system
were
subject
this
study.
In
its
implementation,
water
samples
collected
monthly
in
aquatic
ecosystem
over
a
year
(from
August
2021
to
July
2022).
these
was
assessed
using
their
Chemical
Oxygen
Demand,
determined
accordance
with
NF
T
90-101
standard.
based
on
SEQ-Eau
V2
quality
guidelines.
Their
COD
seasonal
mean
values
between
220,000±51,872
361,333±48,273
mg/L
O2.
So,
relatively
very
significant,
corollary
zero
transparencies
dissolved
oxygen
contents.
dynamics
matter
essentially
linked
hydroclimate
(rainfall
ambient
temperature)
watershed
system.
low
meteorite
inputs
dry
seasons
favoured
increase
by
important
punctual
wastes
various
origins
(domestic,
agricultural,
industrial,
hospital,
etc.);
opposite
rainy
causing
renewal.
consequences
are
severe
risks,
as
highlighted
is
under
strong
anthropogenic
pressures.
This
study
could
serve
complementary
information
contribute
decision-making
for
rehabilitation,
protection
within
framework
sustainable
development.
Bulletin of Environmental Contamination and Toxicology,
Год журнала:
2023,
Номер
112(1)
Опубликована: Дек. 12, 2023
Abstract
Pesticides
enter
non-target
surface
waters
as
a
result
of
agricultural
activities
and
may
reach
water
bodies
in
protected
areas.
We
measured
southwestern
Germany
pesticide
concentrations
after
heavy
rainfalls
streams
drinking
protection
area
near
Hausen
(Freiburg)
the
catchment
Queich
(Landau),
which
originates
from
biosphere
reserve
Palatinate
Forest.
On
average,
32
(n
=
21)
21
10)
pesticides
were
detected
per
sample
event
56)
17),
respectively.
The
majority
>
50%
all
samples
fungicides,
with
fluopyram
being
throughout
samples.
Aquatic
invertebrates
exhibited
highest
risks
16.1%
exceeding
mixture
toxicity
thresholds,
whereas
lower
for
aquatic
plants
(12.9%)
fish
(6.5%).
Mixture
threshold
exceedances
indicate
adverse
ecological
effects
to
occur
at
half
sites
(50%).
This
study
illustrates
presence
mixtures
highlights
organisms
areas
Germany.
Current Opinion in Environmental Science & Health,
Год журнала:
2024,
Номер
41, С. 100569 - 100569
Опубликована: Авг. 8, 2024
As
synthetic
pesticides
contribute
to
the
global
decline
of
pollinators,
biopesticides
have
gained
attention
as
more
sustainable
pest
management
alternatives
in
agriculture.
Despite
their
perceived
safety,
there
is
increasing
evidence
that
bioinsecticides
can
harm
honey
bees,
which
are
crucial
pollinators
many
commercial
crops
and
key
ecotoxicological
models.
This
short
review
aims
summarize
studies
on
exposure
pathways
sublethal
effects
highlighting
outdated
risk
assessment
paradigms
critical
evaluation
issues.
We
discuss
need
for
novel
approaches,
such
molecular
techniques
AI
technologies,
better
understand
mitigate
bees.
also
highlight
importance
long-term
field
ethical
considerations
ecotoxicology
protect
bees
promote
agricultural
practices.
Frontiers in Environmental Science,
Год журнала:
2023,
Номер
11
Опубликована: Ноя. 6, 2023
An
increase
in
herbicide
use
is
occurring
due
to
a
growing
population
and
herbicide-resistant
crops
agriculture,
which
has
resulted
more
tolerant
target
species.
Glyphosate
2,4-Dichlorophenoxyacetic
acid
(2,4-D)
are
two
of
the
most
commonly
used
herbicides
worldwide
recently
being
combination
pre-mixed
commercial
formulas.
Subsequently,
contamination
wetlands
will
exposure
microorganisms
multiple
chemical
stressors.
Methane
potent
greenhouse
gas
naturally
emitted
from
wetlands,
but
may
disrupt
biogeochemical
processes
leading
an
unbalanced
methane
cycle.
We
review
impacts
these
on
aquatic
microbial
communities
glyphosate-derived
nutrient
enrichment
2,4-D
inhibition
oxidation,
examine
how
altered
metabolic
lead
increased
production
wetlands.
The
response
wetland
ecosystems
vary
across
regions,
part
complexity
communities,
however,
this
perspective
gives
glimpse
into
potential
global
implications
continuing
demonstrates
importance
for
research
ecosystem-level
co-stressors.
Science Letters,
Год журнала:
2024,
Номер
12(1), С. 1 - 9
Опубликована: Фев. 12, 2024
This
work
aimed
to
study
the
modeling
of
organic
pollution
waters
Déganobo
Lake
system
by
three
models:
Multiple
Linear
Regression
model
(MLR
model),
Mutilayer
Perceptron
(MLP
model)
and
Regression/
hybrid
(MLR/MLP
model).
In
its
implementation,
chemical
oxygen
demand
(COD)
these
waters,
obtained
from
August
2021
July
2022,
was
used.
Two
approaches
were
done
in
case
their
COD
MLP
MLR/MLP
model:
static
dynamic
modeling.
The
results
have
highlighted
low
predictions
MLR
(36.2
%)
models
(6-8-1
for
7-3-1
modeling,
both
predicting
less
than
35%
experimental
values
with
high
error
(RMSE
upper
1.30
relative
0.750).
However,
(MLR/6-3-1
MLR/7-3-1
modeling)
well
predicted
around
99%
very
errors
0.0001
0.006
cases).
So,
most
efficient
predict
waters.
accuracy
this
ecological
again
provided
during
study.
bioRxiv (Cold Spring Harbor Laboratory),
Год журнала:
2024,
Номер
unknown
Опубликована: Апрель 17, 2024
Abstract
Chemical
exposomes
can
now
be
comprehensively
measured
in
human
blood,
but
robust
application
of
chemical
exposomics
cohort
studies
requires
knowledge
the
longitudinal
stability
and
interindividual
variability
exogenous
molecular
profiles.
Here
we
applied
to
plasma
46
adults,
each
sampled
six
times
over
two
years
a
multiomic
wellness
cohort.
New
chemicals
were
discovered,
distinctive
co-exposure
patterns
observed,
intra-class
correlation
coefficients
(ICC)
for
519
confidently
annotated
substances
are
reported
support
study
design.
Longitudinal
exposome
(mean
ICC
0.30)
was
significantly
lower
than
proteome,
metabolome,
lipidome
or
microbiome,
must
more
frequently
other
profiles
health
studies.
Mixed-effects
models
nevertheless
revealed
significant
associations
between
testosterone
perfluoroalkyl
substances,
time-trends
low
high
exposures
alike.
Complex
data
structures
visualized
explored,
demonstrating
great
potential
precision
research.
Teaser
The
first
cohort-level
novel
dynamic
co-exposures
blood
relevance
health.
