Recent design strategies for boosting chemodynamic therapy of bacterial infections

Exploration, Год журнала: 2023, Номер 4(2)

Опубликована: Окт. 17, 2023

Abstract The emergence of drug‐resistant bacteria poses a significant threat to people's lives and health as bacterial infections continue persist. Currently, antibiotic therapy remains the primary approach for tackling infections. However, escalating rates drug resistance coupled with lag in development novel drugs have led diminishing effectiveness conventional treatments. Therefore, nonantibiotic‐dependent therapeutic strategies has become imperative impede rise resistance. chemodynamic (CDT) opened up new possibility due CDT can convert H 2 O into •OH via Fenton/Fenton‐like reaction treatment. efficacy is limited by variety practical factors. To overcome this limitation, sterilization efficiency be enhanced introducing therapeutics inherent antimicrobial capability. In addition, researchers explored CDT‐based combined therapies augment its effects mitigate potential toxic side toward normal tissues. This review examines research progress field, explores various enhance presents synergistic combination other modalities. And last, current challenges faced future directions are discussed.

Язык: Английский

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Structural and antibacterial activity of developed nano-bioceramic DD3/ZrO2/ZnO/CuO powders

Journal of the Korean Ceramic Society, Год журнала: 2024, Номер 61(5), С. 837 - 853

Опубликована: Май 6, 2024

Язык: Английский

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Methyl gallate: Review of pharmacological activity

Pharmacological Research, Год журнала: 2023, Номер 194, С. 106849 - 106849

Опубликована: Июль 8, 2023

Methyl gallate (MG) is a polyphenolic compound widely found in natural plants. MG has been shown to have variety of biological functions, including anti-tumor, anti-inflammatory, anti-oxidant, neuroprotective, hepatoprotective and anti-microbial activities, broad research development prospects. A total 88 articles related were searched using the PubMed, Science Direct, Google Scholar databases, systematically investigating pharmacological activity molecular mechanisms MG. There no restrictions on publication years, last search was conducted June 5, 2023. can exert effects through multiple pathways targets, such as PI3K/Akt, ERK1/2, Caspase, AMPK/NF-κB, Wnt/β-catenin, TLR4/NF-κB, MAPK, p53, NLRP3, ROS, EMT. According literature, potential be prospective adjuvant for anticancer therapy deserves further study.

Язык: Английский

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Enhanced Bacterial‐Infected Wound Healing by Nitric Oxide‐Releasing Topological Supramolecular Nanocarriers with Self‐Optimized Cooperative Multi‐Point Anchoring

Advanced Science, Год журнала: 2023, Номер 10(11)

Опубликована: Фев. 15, 2023

Polymeric systems that provide cationic charges or biocide-release therapeutics are used to treat the bacteria-infected wound. However, most antibacterial polymers based on topologies with restricted molecular dynamics still do not satisfy clinical requirements due their limited efficacy at safe concentrations in vivo. Here a NO-releasing topological supramolecular nanocarrier rotatable and slidable entities is reported conformational freedom promote interactions between carrier pathogenic microbes, hence greatly improving performance. With improved contacting-killing efficient delivery of NO biocide from molecularly dynamic ligand design, NO-loaded achieves excellent anti-biofilm effects via destroying bacterial membrane DNA. MRSA-infected rat model also brought out demonstrate its wound-healing effect neglectable toxicity Introducing flexible motions into therapeutic polymeric general design enhance healing range diseases.

Язык: Английский

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Predicting Antimicrobial Peptides Using ESMFold-Predicted Structures and ESM-2-Based Amino Acid Features with Graph Deep Learning

Journal of Chemical Information and Modeling, Год журнала: 2024, Номер 64(10), С. 4310 - 4321

Опубликована: Май 13, 2024

Currently, antimicrobial resistance constitutes a serious threat to human health. Drugs based on peptides (AMPs) constitute one of the alternatives address it. Shallow and deep learning (DL)-based models have mainly been built from amino acid sequences predict AMPs. Recent advances in tertiary (3D) structure prediction opened new opportunities this field. In sense, graphs derived predicted peptide structures recently proposed. However, these are not correspondence with state-of-the-art approaches codify evolutionary information, and, addition, they memory- time-consuming because depend multiple sequence alignment. Herein, we presented framework create alignment-free graph representations generated ESMFold-predicted structures, whose nodes characterized acid-level information Evolutionary Scale Modeling (ESM-2) models. A attention network (GAT) was implemented assess usefulness AMP classification. To end, set comprised 67,058 used. It demonstrated that proposed methodology allowed build GAT generalization abilities consistently better than 20 non-DL-based DL-based The best were developed using 36- 33-layer ESM-2 Similarity studies showed best-built codified different chemical spaces, thus fused significantly improve general, results suggest esm-AxP-GDL is promissory tool develop good, structure-dependent, can be successfully applied screening large data sets. This should only useful classify AMPs but also for modeling other protein activities.

Язык: Английский

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Novel aminothiazoximone-corbelled ethoxycarbonylpyrimidones with antibiofilm activity to conquer Gram-negative bacteria through potential multitargeting effects

European Journal of Medicinal Chemistry, Год журнала: 2024, Номер 268, С. 116219 - 116219

Опубликована: Фев. 13, 2024

Язык: Английский

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Unveiling sustainable, greener synthesis strategies and multifaceted applications of copper oxide nanoparticles

Journal of Molecular Structure, Год журнала: 2024, Номер 1305, С. 137788 - 137788

Опубликована: Фев. 11, 2024

Язык: Английский

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Peptide Dendrimer-Based Antibacterial Agents: Synthesis and Applications

ACS Infectious Diseases, Год журнала: 2024, Номер 10(4), С. 1034 - 1055

Опубликована: Март 1, 2024

Pathogenic bacteria cause the deaths of millions people every year. With development antibiotics, hundreds and thousands people's lives have been saved. Nevertheless, can develop resistance to rendering them insensitive antibiotics over time. Peptides containing specific amino acids be used as antibacterial agents; however, they easily degraded by proteases in vivo. To address these issues, branched peptide dendrimers are now being considered good agents due their high efficacy, protease degradation, low cytotoxicity. The ease with which synthesized modified makes accessible for use various biological nonbiological fields. That is, hold a promising future prolonged efficacy without bacterial development. Their vivo stability multivalence allow effectively target multi-drug-resistant strains prevent biofilm formation. Thus, it is interesting an overview applications research, including possibility employing machine learning approaches design AMPs dendrimers. This review summarizes synthesis agents. challenges perspectives using also discussed.

Язык: Английский

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Efficacy and Safety of a Probiotic Containing Saccharomyces boulardii CNCM I-745 in the Treatment of Small Intestinal Bacterial Overgrowth in Decompensated Cirrhosis: Randomized, Placebo-Controlled Study

Journal of Clinical Medicine, Год журнала: 2024, Номер 13(3), С. 919 - 919

Опубликована: Фев. 5, 2024

(1) Background: The aim was to evaluate the effectiveness of probiotic containing Saccharomyces boulardii in treatment small intestinal bacterial overgrowth (SIBO) patients with decompensated cirrhosis. (2) Methods: This a blinded, randomized, placebo-controlled study. (3) Results: After 3 months treatment, SIBO absent 80.0% group and 23.1% placebo (p = 0.002). eliminated had decreased frequency ascites hepatic encephalopathy, increased platelets albumin levels, blood levels total bilirubin, biomarkers translocation (lipopolysaccharide [LPS]) systemic inflammation (C-reactive protein), positive changes markers hyperdynamic circulation compared state at inclusion. There were no significant claudin level (the barrier biomarker) these patients. No observed persistent SIBO. serum nitrate (endothelial dysfunction lower eradicated than One (5.3%) patient six (42.9%) died within first year follow-up 0.007). (4) Conclusions: eradication an independent predictor favorable prognosis during follow-up.

Язык: Английский

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Antimicrobial Peptides and Their Mimetics: Promising Candidates of Next‐Generation Therapeutic Agents Combating Multidrug‐Resistant Bacteria

Advanced Biology, Год журнала: 2025, Номер unknown

Опубликована: Фев. 6, 2025

Abstract The increasing morbidity and mortality caused by multidrug‐resistant bacteria alerts human beings to the fact that conventional antibiotics are no longer reliable effective alternatives imperatively needed. Owing wide range of sources, diverse structures, unique mode action, antimicrobial peptides have been highly anticipated extensively studied in recent years. Besides, integration artificial intelligence helps researchers gain access vast unexplored chemical space, which opens more opportunities for optimization design novel structures. Moreover, Due advances chemistry synthetic biology, also begun focus on potential mimetics peptides. In this review, a comprehensive discussion about natural synthesized as well their is made, so provide summary field inspire follow‐up research.

Язык: Английский

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