Interactions of the maternal microbiome with diet, stress, and infection influence fetal development

FEBS Journal, Год журнала: 2025, Номер unknown

Опубликована: Фев. 23, 2025

Humans and other animals contain multitudes of microorganisms including bacteria, fungi, viruses, which make up a diverse microbiome. Across body sites skin, gastrointestinal tract, oral cavity there are distinct microbial niches that made trillions have co‐evolved to inhabit interact with the host. The microbiome also interacts changing environment. This tripartite interaction between host, microbiome, environment suggests communities play key role in biological processes such as development behaviors. Over past two decades, emerging research continues reveal how host microbe interactions impact nervous system signaling behaviors, influence neurodevelopmental, neurological, neurodegenerative disorders. In this review, we will describe unique features maternal exist during perinatal period discuss evidence for function offspring development. Finally, then postulate can modify early lasting on brain health.

Язык: Английский

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Developmental Programming: Sex-specific Effects of Prenatal Exposure to a Real-Life Mixture of Environmental Chemicals on Liver Function and Transcriptome in Sheep.

Environmental Pollution, Год журнала: 2025, Номер 367, С. 125630 - 125630

Опубликована: Янв. 5, 2025

Язык: Английский

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Advancing sustainable agriculture through multi-omics profiling of biosolids for safe application: A review

Journal of Environmental Management, Год журнала: 2025, Номер 375, С. 124292 - 124292

Опубликована: Янв. 31, 2025

Biosolids, derived from wastewater treatment processes, are valuable resources for soil amendment in agriculture due to their nutrient-rich composition. However, various contaminants of concern (CEC) such as pharmaceuticals, per-and poly-fluoroalkyl substances, endocrine disruptive chemicals, surfactants, pathogens, nanoplastics, and microplastics, also reported biosolids. The use biosolids may introduce these CEC into the soil, which raises concerns about environmental human health impacts. Moreover, presence pathogens (Escherichia coli, Salmonella sp., Shigella, Giardia, Rotavirus, etc.) even after calls microbial profiling biosolids, especially developing countries. Multi-omics approaches can be used powerful tools characterizing communities highlighting metabolic pathways. help predicting ecological agronomic effects application agricultural soils. This review discusses advantages challenges using agriculture, considering range different current legislation is presented, limitations with respect guidelines emerging Furthermore, role multi-omics approach management, focusing on genomics, transcriptomics, proteomics, metabolomics assessed. allows real-time monitoring, ensuring continuous optimization towards changing conditions. dynamic not only enhances safe use, but sustainability waste management practices, minimizing negative effects. Finally, future research directions integrating biosolid practices suggested. need updating legislative framework, continued innovation promote sustainable robust systems, bringing process closer principles a circular bioeconomy empahasized.

Язык: Английский

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Nanoparticle-Mediated Embryotoxicity: Mechanisms of Chemical Toxicity and Implications for Biological Development

Chemical Research in Toxicology, Год журнала: 2025, Номер unknown

Опубликована: Март 19, 2025

Nanoparticles, defined by their nanoscale dimensions and unique physicochemical properties, are widely utilized in healthcare, electronics, environmental sciences, consumer products. However, increasing evidence of potential embryotoxic effects during pregnancy underscores the need for a molecular-level understanding interactions embryonic development. Nanoparticles such as titanium dioxide, silver, cerium oxide, copper quantum dots can cross placental barrier interfere with crucial developmental processes. At molecular level, they disrupt signaling pathways like Wnt Hedgehog, induce oxidative stress inflammation, cause genotoxic effects, all critical sensitive phases, organogenesis. Furthermore, these nanoparticles interact directly cellular components, including DNA, proteins, lipids, impairing function viability. Innovative strategies to mitigate nanoparticle toxicity, surface modifications incorporation biocompatible coatings, discussed solutions reduce adverse interactions. Various laboratory animal models used investigate nanoparticle-induced embryotoxicity evaluated efficacy limitations, providing insights into applicability effects. This Account examines mechanisms which compromise development emphasizes importance designing safer minimize maternal-fetal exposure risks, particularly biomedical applications.

Язык: Английский

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Developmental programming: Impact of preconceptional and gestational exposure to a real-life environmental chemical mixture on maternal steroid, cytokine and oxidative stress milieus in sheep

The Science of The Total Environment, Год журнала: 2023, Номер 900, С. 165674 - 165674

Опубликована: Июль 25, 2023

Язык: Английский

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Sexually dimorphic impact of preconceptional and gestational exposure to a real-life environmental chemical mixture (biosolids) on offspring growth dynamics and puberty in sheep

Environmental Toxicology and Pharmacology, Год журнала: 2023, Номер 102, С. 104257 - 104257

Опубликована: Сен. 1, 2023

Humans are ubiquitously exposed to complex mixtures of environmental chemicals (ECs). This study characterised changes in post-natal and peripubertal growth, the activation reproductive axis, male female offspring sheep a translationally relevant EC mixture (in biosolids), during pregnancy. Birthweight both sexes was unaffected by gestational biosolids exposure. In contrast females (unaffected), bodyweight males significantly lower than controls across period, however, they exhibited catch-up growth eventually surpassing controls. Despite weighing less, testosterone concentrations were elevated earlier, indicative early puberty males. contrasted with which mean date (first progesterone cycle) delayed. These results demonstrate that developmental EC-mixture exposure has sexually dimorphic effects on relationship between body size puberty. Such programmed metabolic/reproductive could have significant impacts human health wellbeing.

Язык: Английский

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Pressures of the urban environment on the endocrine system: Adverse effects and adaptation

Molecular and Cellular Endocrinology, Год журнала: 2023, Номер 583, С. 112125 - 112125

Опубликована: Дек. 24, 2023

Язык: Английский

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Biosolids and male reproduction

Reproduction, Год журнала: 2024, Номер 168(2)

Опубликована: Июнь 7, 2024

Over the past 50 years, there has been a concerning decline in male reproductive health and an increase infertility which is now recognised as major concern globally. While can be linked to some genetic lifestyle factors, these do not fully explain rate of declining health. Increasing evidence from human animal studies suggests that exposure chemicals found ubiquitously environment may part play role. Many on chemical exposure, however, have assessed effects individual environmental (ECs), usually at levels relevant everyday exposure. There need for study models reflect 'real-life' nature EC One such model biosolids-treated pasture (BTP) sheep utilises biosolids application agricultural land examine low-level mixtures chemicals. Biosolids are by-product treatment wastewater industrial domestic sources so their composition reflective ECs humans exposed. last 20 BTP published multiple offspring physiology including consistent system fetal, neonatal, juvenile, adult offspring. This review focuses strongly during gestation alter several components highlights more real-life effects.

Язык: Английский

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Intra‐uterine programming of future fertility

Reproduction in Domestic Animals, Год журнала: 2023, Номер 59(5)

Опубликована: Ноя. 9, 2023

Abstract The developmental origins of health and disease (DOHaD) shows that a relationship exists between parental environment at large, foeto‐placental development the risk for offspring to develop non‐transmittable disease(s) in adulthood. This concept has been validated both humans livestock. In mammals, after fertilization time spent free maternal reproductive tract, embryo develops placenta that, close with endometrium, is organ responsible exchanges dam foetus. Any modification can lead adaptive mechanisms affecting placental morphology, blood flow, foetal‐maternal (transporters) and/or endocrine function, ultimately modifying efficiency. Among deleterious environments, undernutrition, protein restriction, overnutrition, micronutrient deficiencies food contaminants be outlined. When capacities become insufficient, foetal growth formation no longer optimal, including gonadal maturation, which affect subsequent fertility. Since epigenetic have shown key programming, modifications gametes may also occur, leading inter‐generational effects. After briefly describing normal domestic species inter‐species differences, this review highlights current knowledge on intra‐uterine programming fertility focus animals underlines importance assess transgenerational effects when new breeding systems are developed face climate changes.

Язык: Английский

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Association of Urinary Benzene Metabolite and the Ratio of Triglycerides to High-Density Lipoprotein Cholesterol: A Cross-Sectional Study Using the Korean National Environmental Health Survey (2018–2020)

Toxics, Год журнала: 2023, Номер 11(12), С. 985 - 985

Опубликована: Дек. 4, 2023

The aim of this study was to investigate the association between benzene and toluene, ratio triglycerides high-density lipoprotein cholesterol (TG/HDL-C). This cross-sectional analyzed 1928 adults using nationally representative data from Korean National Environmental Health Survey (KoNEHS) Cycle 4 (2018-2020). Urinary trans, trans-muconic acid (t,t-MA) benzylmercapturic (BMA) were measured by high-performance liquid chromatography-mass spectrometry (HPLC-MS/MS), (HDL-C) (TGs) colorimetry. logistic regression analysis applied examine urinary t,t-MA BMA TG/HDL-C ratio. is significantly associated with an elevated in both men women (for men, OR [95% (CI)]: 2nd quartile: 2.10 [1.04, 4.22]; 3rd 2.13 [0.98, 4.62]; 4th 2.39 [1.05, 5.45]; for women, 1.21 [0.71, 2.06]; 1.65 [0.94, 2.90]; 1.78 [1.01, 3.11]), significant dose-response relationships (P trend: 0.029; 0.024). shows that environmental exposure general population. suggests more stringent health policies are needed reduce exposure.

Язык: Английский

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