Journal of Zhejiang University (Medical Sciences),
Год журнала:
2024,
Номер
unknown
Опубликована: Дек. 1, 2024
It
has
been
confirmed
that
exposure
to
various
metal
pollutants
can
induce
neurotoxicity,
which
is
closely
associated
with
the
occurrence
and
development
of
neurological
disorders.
Ferroptosis
a
form
cell
death
in
response
pollutant
it
related
oxidative
stress,
iron
metabolism
lipid
peroxidation.
Recent
studies
have
revealed
ferroptosis
plays
significant
role
neurotoxicity
induced
by
metals
such
as
lead,
cadmium,
manganese,
nickel,
antimony.
Lead
triggers
through
disorder
inflammation.
Cadmium
ion
metabolism,
stress
signaling
pathways
IRE1/JNK/FTH1.
Manganese
promote
mitochondrial
dysfunction,
stress.
Nickel
influencing
function,
disrupting
homeostasis
facilitating
peroxidation
central
nervous
system.
Antimony
glutathione
depletion
activating
autophagy,
resulting
excessive
intracellular
deposition
ultimately
causing
ferroptosis.
This
article
reviews
effects
on
ferroptosis-related
indicators
discusses
specific
mechanisms
each
may
provide
references
identify
targets
preventing
develop
treatment
strategies
Frontiers in Cellular and Infection Microbiology,
Год журнала:
2025,
Номер
15
Опубликована: Март 12, 2025
B.
microti
is
a
tick-transmitted
zoonotic
erythrocytic
intracellular
parasite.
Ferroptosis
an
iron-dependent
form
of
programmed
cell
death
that
affects
pathogen
replication
in
the
host.
Currently,
there
limited
research
concerning
effect
tick
ferroptosis
on
Babesia
infection
and
underlying
mechanism
action.
The
present
study
used
-mouse-
Haemaphysalis
longicornis
model
which
nymphs
fed
blood
-infected
mice.
midgut
divalent
iron
(
p<0.01
)
reactive
oxygen
species
(ROS)
p<0.05
levels
were
significantly
elevated
infected
ticks,
transmission
electron
microscopy
(TEM)
showed
mitochondrial
ridges
absent
or
decreased
size.
Downregulation
ferritin
1
glutathione
peroxidase
4
(GPX4)
ticks
with
suggests
these
changes
promote
ferroptosis.
In
vivo
studies
demonstrated
promoter
Erastin
increased
load
),
while
inhibitor
Ferrostatin-1
effectively
).
Tick
histamine-releasing
factor
(HRF),
protein
related
to
antioxidant
system,
was
downregulated
compared
uninfected
interference
HRF
promoted
acquisition
p<0.001
Transcriptomic
analyses
promotes
by
downregulating
GPX4.
Meanwhile,
molecules
ROS
controls.
These
findings
highlight
critical
role
regulating
,
thereby
providing
important
insights
for
deeper
understanding
tick-
interaction.
Ecotoxicology and Environmental Safety,
Год журнала:
2024,
Номер
283, С. 116947 - 116947
Опубликована: Авг. 29, 2024
The
impact
of
cadmium
(Cd)
toxicity
on
fish
liver
injury
has
received
much
attention
in
recent
years.
Currently,
autophagy,
apoptosis
and
endoplasmic
reticulum
stress
were
reported
Cd
exposed
liver,
if
there
are
other
mechanisms
(such
as
ferroptosis)
relevant
signaling
pathways
involved
remains
unknown.
An
experiment
was
conducted
to
investigate
Channa
argus
(Cantor,
1842)
0,
1.0,
2.0
mg
Cd/L
water
for
96
h.
disrupted
the
structure
mitochondria
liver.
Besides,
induced
ferroptosis
by
significantly
increasing
level
Fe
Immunological Reviews,
Год журнала:
2023,
Номер
319(1), С. 27 - 44
Опубликована: Авг. 17, 2023
Summary
The
clearance
of
dead
and
dying
cells,
termed
efferocytosis,
is
a
rapid
efficient
process
one
that
critical
for
organismal
health.
extraordinary
speed
efficiency
with
which
cells
are
detected
engulfed
by
immune
within
tissues
presents
challenge
to
researchers
who
wish
unravel
this
fascinating
process,
since
these
fleeting
moments
uptake
almost
impossible
catch
in
vivo.
In
recent
years,
the
fruit
fly
(
Drosophila
melanogaster)
embryo
has
emerged
as
powerful
model
circumvent
problem.
With
its
abundance
specialist
phagocytes
relative
ease
live
imaging,
humble
provides
unique
opportunity
study
moment
cell
engulfment
real‐time
living
animal.
review,
we
explore
advances
have
come
from
studies
fly,
how
imaging
genetics
revealed
previously
unappreciated
level
diversity
efferocytic
program.
A
variety
strategies
across
phagocytic
population
ensure
corpses
wherever
death
encountered
varied
complex
setting
multicellular
organism.
Desalination and Water Treatment,
Год журнала:
2023,
Номер
307, С. 120 - 129
Опубликована: Сен. 1, 2023
Cadmium
(Cd)
emissions
have
a
negative
impact
on
both
human
health
and
the
environment.Although
nano
zero-valent
iron
(nZVI)
offers
lot
of
potential
for
water
pollution
treatment,
it
has
been
constrained
by
its
instability
ease
aggregation.For
elimination
Cd(II)
from
aqueous
solution,
nZVI/MCM
supported
nZVI
(nZVI/MCM-41/rGO)
was
designed
to
improve
dispersion
stability.It
had
rough,
porous
structure
with
apparent
Fe
(0)
crystallinity
slight
rGO
crystallinity.On
surface
nZVI/MCM-41/rGO,
several
oxygen-containing
groups
were
detected.The
specific
area
15.94
cm
2
/g,
pore
diameter
concentrated
at
23.82
nm.The
best
performance
occurred
pH
6
an
adsorbent
dosage
g/L,
maximum
adsorption
capacity
31
mg/g
achieved
after
600
min.Cd(II)
removal
process
well
fitted
second-order
kinetic,
Langmuir
Freundlich
isotherm.The
thermodynamic
parameter
also
analyzed
proved
that
endothermic
(ΔH°
>
0)
spontaneous
(ΔG°
<
progress.During
adsorption,
crystal
type
functional
nZVI/MCM-41/
did
not
change,
but
oxidized.
Journal of Engineering,
Год журнала:
2024,
Номер
2024(1)
Опубликована: Янв. 1, 2024
Heavy
metals
exhibit
characteristics
such
as
nonbiodegradable
nature,
toxic
character,
bioaccumulation
capability,
and
ability
to
transit
over
long
distances.
The
widespread
application
of
these
metal
ions
in
various
industrial
sectors
has
led
an
increase
their
release
into
the
environment.
Chemical
precipitation
been
one
technologies
used
remove
heavy
from
wastewater,
involving
a
process
which
chemical
agents
are
added
wastewater
with
dissolved
ions,
react
metals,
forming
insoluble
precipitates.
Therefore,
present
study
aimed
assess
potential
gypsum
adhesive
mortar
type
III
(ACIII)
precipitating
for
lead
(Pb)
copper
(Cu)
well
evaluate
toxicity
products
on
Drosophila
melanogaster
.
Experiments
using
ACIII
waste
agent
Cu
were
obtained
glass
filter
composed
04
chambers
antechambers,
while
Pb
ion
precipitant
was
evaluated
by
adding
powder
beaker
containing
solution.
observing
mortality
negative
geotaxis
parameters
D.
In
tests
Cu,
retention
percentages
progressively
varied,
obtaining
98.82%
at
concentration
30
mg/L.
Meanwhile,
that
varied
32.83
98.61%
Pb.
It
found
precipitates
resulted
alterations
survival
locomotion
rates
only
highest
concentrations.
conclusion,
results
indicated
geomaterials
have
removal
aqueous
solutions.
Moreover,
stages
materials
also
impact
decreasing
model
organism.