Environmentally realistic dose of tire-derived metabolite 6PPD-Q exposure causes intestinal jejunum and ileum damage in mice via cannabinoid receptor-activated inflammation

The Science of The Total Environment, Год журнала: 2024, Номер 918, С. 170679 - 170679

Опубликована: Фев. 5, 2024

Язык: Английский

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Occurrence of Multiple Classes of Emerging Synthetic Antioxidants, Including p-Phenylenediamines, Diphenylamines, Naphthylamines, Macromolecular Hindered Phenols, and Organophosphites, in Human Milk: Implications for Infant Exposure

Environmental Science & Technology Letters, Год журнала: 2024, Номер 11(3), С. 259 - 265

Опубликована: Фев. 26, 2024

Synthetic antioxidants (AOs) have received increasing attention in recent years due to their environmental ubiquity. However, lactational exposure these emerging contaminants of current concern remains unknown. In this study, 21 amine antioxidants, 18 macromolecular hindered phenol 3 organophosphite and 2 p-phenylenediamine-derived quinones (PPD-Qs) were integrated into a dedicated screening human milk from South China. Among all 42 target AOs, 19 detected, but no PPD-Qs detected any the samples. Eight including N-(1,3-dimethylbutyl)-N′-phenyl-p-phenylenediamine (6PPD), frequently more than half The summed concentrations detectable AOs ranged 133 7,560 pg/mL, with median 713 pg/mL. Significant correlations observed among antioxidants. preliminary risk assessment revealed that under high scenario, overall daily intake identified through breastfeeding might pose non-negligible health newborns. This study is first attempt comprehensively identify wide range prevalent milk. findings call for urgent infant widely used less well evaluated chemicals possible increased accumulative future.

Язык: Английский

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Chronic exposure to tire rubber-derived contaminant 6PPD-quinone impairs sperm quality and induces the damage of reproductive capacity in male mice

Journal of Hazardous Materials, Год журнала: 2024, Номер 470, С. 134165 - 134165

Опубликована: Март 28, 2024

Язык: Английский

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p-Phenylenediamine Derivatives in Tap Water: Implications for Human Exposure

Water, Год журнала: 2024, Номер 16(8), С. 1128 - 1128

Опубликована: Апрель 16, 2024

Human exposure to p-phenylenediamine derivatives (PPDs) may induce hepatotoxicity and altered glycolipid metabolism. Recent studies have demonstrated the wide presence of PPDs in environmental matrixes. However, until now, occurrence tap water has not been well known. This study analyzed nine collected from Hangzhou Taizhou, China. The results showed that seven were detected samples (n = 131), with concentration total ranging 0.29 7.9 ng/L (mean: 1.6 ng/L). N-(1, 3-dimethylbutyl)-N′-phenyl-p-phenylenediamine (6PPD; mean: 0.79 ng/L, <LOD−5.7 ng/L) was predominant PPD Hangzhou, followed by N, N′-di-2-butyl-p-phenylenediamine (44PD; 0.39 <LOD−2.2 N-isopropyl-N′-phenyl-1, 4-phenylenediamine (IPPD; 0.31 <LOD−1.4 Five Taizhou 30). N-phenyl-N′-cyclohexyl-p-phenylenediamine (CPPD; 1.0 <LOD−4.2 6PPD (0.93 <LOD−2.6 44PD (0.78 <LOD−1.8 mean daily intake (DI) for adults children estimated be 4.9–24 6.4–32 pg/kg bw/day, respectively. Meanwhile, DI living 11–31 14–40 To our knowledge, this provides first data on water, which is vital human risk assessment.

Язык: Английский

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Environmental profiles, hazard identification, and toxicological hallmarks of emerging tire rubber-related contaminants 6PPD and 6PPD-quinone

Environment International, Год журнала: 2024, Номер 187, С. 108677 - 108677

Опубликована: Апрель 21, 2024

N-(1,3-dimethylbutyl)-N'-phenyl-p-phenylenediamine (6PPD) is commonly used in rubber compounds as antioxidants to protect against degradation from heat, oxygen, and ozone exposure. This practice extends the lifespan of products, including tires, by preventing cracking, aging, deterioration. However, environmental consequences waste generated during product use, particularly formation 6PPD-quinone (6PPD-Q) through reaction 6PPD with ozone, have raised significant concerns due their detrimental effects on ecosystems. Extensive research has revealed widespread occurrence its derivate 6PPD-Q various compartments, air, water, soil. The emerging substance been shown pose acute mortality long-term hazards aquatic terrestrial organisms at concentrations below environmentally relevant levels. Studies demonstrated toxic a range organisms, zebrafish, nematodes, mammals. These include neurobehavioral changes, reproductive dysfunction, digestive damage exposure pathways. Mechanistic insights suggest that mitochondrial stress, DNA adduct formation, disruption lipid metabolism contribute toxicity induced 6PPD-Q. Recent findings human samples, such blood, urine, cerebrospinal fluid, underscore importance further public health toxicological implications these compounds. distribution, fate, biological effects, underlying mechanisms environment highlight urgent need for additional understand address impacts

Язык: Английский

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Exposure to 6-PPD quinone causes damage on mitochondrial complex I/II associated with lifespan reduction in Caenorhabditis elegans

Journal of Hazardous Materials, Год журнала: 2024, Номер 472, С. 134598 - 134598

Опубликована: Май 13, 2024

Язык: Английский

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AHR/cyp1b1 signaling-mediated extrinsic apoptosis contributes to 6PPDQ-induced cardiac dysfunction in zebrafish embryos

Environmental Pollution, Год журнала: 2024, Номер 345, С. 123467 - 123467

Опубликована: Фев. 2, 2024

Язык: Английский

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6PPD induced cardiac dysfunction in zebrafish associated with mitochondrial damage and inhibition of autophagy processes

Journal of Hazardous Materials, Год журнала: 2024, Номер 471, С. 134357 - 134357

Опубликована: Апрель 21, 2024

Язык: Английский

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Potential human health risk of the emerging environmental contaminant 6-PPD quinone

The Science of The Total Environment, Год журнала: 2024, Номер 949, С. 175057 - 175057

Опубликована: Июль 26, 2024

Язык: Английский

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Prediction of p-phenylenediamine antioxidant concentrations in human urine using machine learning models

Journal of Hazardous Materials, Год журнала: 2025, Номер 487, С. 137184 - 137184

Опубликована: Янв. 11, 2025

Язык: Английский

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