Sepsis
is
defined
as
a
life-threatening
organ
dysfunction
caused
by
dysregulated
host
response
to
infection.
It
characterized
high
morbidity
and
mortality
one
of
the
major
diseases
that
seriously
hang
over
global
human
health.
Autophagy
crucial
regulator
in
complicated
pathophysiological
processes
sepsis.
The
activation
autophagy
known
be
great
significance
for
protecting
sepsis
induced
dysfunction.
Recent
research
has
demonstrated
N6-methyladenosine
(m6A)
methylation
well-known
post-transcriptional
RNA
modification
controls
epigenetic
gene
expression
well
number
biological
In
addition,
m6A
affects
stability,
export,
splicing
translation
transcripts
involved
autophagic
process.
Although
it
been
suggested
regulates
metabolic
more
frequently
seen
progression
pathogenesis,
underlying
molecular
mechanisms
m6A-modified
have
not
thoroughly
elucidated.
present
article
fills
this
gap
providing
an
review
its
potential
role
development
novel
therapeutics.
Journal of Advanced Research,
Год журнала:
2025,
Номер
unknown
Опубликована: Янв. 1, 2025
Neurodegenerative
diseases
(NDs)
constitute
a
significant
public
health
challenge,
as
they
are
increasingly
contributing
to
global
mortality
and
morbidity,
particularly
among
the
elderly
population.
Pathogenesis
of
NDs
is
intricate
multifactorial.
Recently,
post-transcriptional
modifications
(PTMs)
RNA,
with
particular
focus
on
mRNA
methylation,
have
been
gaining
increasing
attention.
At
present,
several
regulatory
genes
associated
methylation
identified
closely
neurodegenerative
disorders.
This
review
aimed
summarize
RNA
enzymes
system,
including
writer,
reader,
eraser
proteins
delve
into
their
functions
in
central
nervous
system
(CNS),
hoping
open
new
avenues
for
exploring
mechanisms
therapeutic
strategies
NDs.
studies
highlighted
critical
role
development
function
CNS,
abnormalities
this
process
may
contribute
brain
damage
NDs,
aberrant
expression
involved
has
implicated
onset
International Journal of Molecular Sciences,
Год журнала:
2023,
Номер
24(18), С. 13897 - 13897
Опубликована: Сен. 9, 2023
Epigenetic
methylation
has
been
shown
to
play
an
important
role
in
transcriptional
regulation
and
disease
pathogenesis.
Recent
advancements
detection
techniques
have
identified
DNA
N6-methyldeoxyadenosine
(6mA)
RNA
N6-methyladenosine
(m6A)
as
modifications
at
the
sixth
position
of
adenine
RNA,
respectively.
While
distributions
functions
6mA
m6A
extensively
studied
prokaryotes,
their
roles
mammalian
brain,
where
they
are
enriched,
still
not
fully
understood.
In
this
review,
we
provide
a
comprehensive
summary
current
research
progress
on
m6A,
well
associated
writers,
erasers,
readers
both
levels.
Specifically,
focus
potential
fundamental
biological
pathways
genome
highlight
significant
regulatory
neurodegenerative
diseases.
Environment International,
Год журнала:
2024,
Номер
190, С. 108897 - 108897
Опубликована: Июль 20, 2024
The
utilization
of
Cobalt
(Co)
has
surged
due
to
it
is
critical
role
in
renewable
energy
technologies
and
other
high-tech
applications.
Concurrently,
the
potential
health
risks
associated
with
Co
exposure
have
raised
concerns.
Previous
studies,
including
our
own,
shown
that
can
impair
learn
memory
functions
as
an
epigenetic
hazard,
even
at
low
concentrations.
In
this
study,
we
explore
mechanisms
Co-induced
ferroptosis
neurodegenerative
damage
both
vivo
vitro,
focusing
on
regulation
by
N6-methyladenosine
(m
Experimental Neurology,
Год журнала:
2024,
Номер
380, С. 114910 - 114910
Опубликована: Авг. 3, 2024
Structural
and
functional
alterations
in
brain
microvascular
endothelial
cells
(BMECs)
caused
by
oxygen-glucose
deprivation
(OGD)
are
involved
the
pathogenesis
of
various
disorders.
AlkB
homolog
5
(ALKBH5)
is
a
primary
m6A
demethylase
that
regulates
cell
processes,
but
its
distinct
roles
BMEC
function
remain
to
be
clarified.
In
present
study,
mouse
middle
cerebral
artery
occlusion
(MCAO)
model,
knockout
ALKBH5
reduced
neurological
deficits,
infarct
volumes
tissue
apoptosis
ischemia/reperfusion
injury.
Evans
blue
leakage
decreased
expression
tight
junction
protein
ZO-1
Occludin
were
also
attenuated
knockout.
During
exploration
underlying
mechanisms
role
BMECs,
we
found
was
induced
at
both
mRNA
levels
hypoxia;
however,
stability
impaired
OGD
treatment.
Knockdown
increased
total
alleviated
OGD-induced
At
same
time,
selective
inhibitor
Cpd
20m
exhibited
protective
effect
on
contrast,
overexpression
sensitivity
BMECs
OGD.
Interestingly,
sequencing
data
revealed
knockdown
ALKBH5altered
many
genes
via
upregulation.
The
gene
verified
real-time
PCR.
Taken
together,
our
results
suggest
ALKBH5,
as
well
target
genes,
plays
important
regulation
through
RNA
activity.
Background:
Alzheimer’s
disease
(AD)
is
the
most
common
neurodegenerative
characterized
by
pathological
accumulation
of
b-amyloid
and
neurofibrillary
tangles.
Despite
substantial
progress
in
both
basic
clinical
research
on
AD,
detailed
mechanism
AD
pathogenesis
still
elusive.
RNA
N6-methyladenosine
methylation
(m6A)
predominant
post-transcriptional
modification
eukaryotic
mRNA,
prominently
enriched
mammalian
brain.
Notably,
m6A-modified
showed
significant
changes
during
development
indicating
an
important
role
this
pathogenesis.
Aim:
In
study,
we
aim
to
provide
a
summary
recent
advances
highlighting
indispensable
m6A
Result:
From
perspective
modification,
review
our
current
understanding
association
between
machinery
risk
factors
as
well
its
involvement
various
pathophysiological
hallmarks
AD.
We
also
discuss
main
obstacles
studies
about
corresponding
caveats
solutions
them.
Conclusion:
This
emphasizes
significance
investigating
context
highlights
considerable
potential
for
emerge
novel
therapeutic
target
Frontiers in Oncology,
Год журнала:
2023,
Номер
13
Опубликована: Дек. 8, 2023
Autophagy,
a
crucial
cellular
mechanism
responsible
for
degradation
and
recycling
of
intracellular
components,
is
modulated
by
an
intricate
network
molecular
signals.
Its
paradoxical
involvement
in
oncogenesis,
acting
as
both
tumor
suppressor
promoter,
has
been
underscored
recent
studies.
Central
to
this
regulatory
are
the
epigenetic
modifications
DNA
RNA
methylation,
notably
presence
N6-methyldeoxyadenosine
(6mA)
genomic
N6-methyladenosine
(m6A)
eukaryotic
mRNA.
The
6mA
modification
adds
extra
dimension
regulation,
potentially
impacting
transcriptional
dynamics
genes
linked
autophagy
and,
especially,
cancer.
Conversely,
m6A
modification,
governed
methyltransferases
demethylases,
influences
mRNA
stability,
processing,
translation,
affecting
central
autophagic
pathways.
As
we
delve
deeper
into
complexities
importance
these
methylation
grows
more
evident.
interplay
6mA,
m6A,
points
layered
mechanism,
illuminating
reactions
range
conditions.
This
review
delves
nexus
between
their
influence
on
cancer
contexts.
By
closely
examining
markers,
underscore
promise
therapeutic
avenues,
suggesting
novel
approaches
intervention
through
modulation.
