Italian Journal of Animal Science,
Год журнала:
2024,
Номер
23(1), С. 241 - 258
Опубликована: Фев. 7, 2024
In
the
European
Union,
withdrawal
of
pharmaceutical
zinc
oxide
(ZnO)
poses
challenges
for
post-weaning
pigs
management.
The
present
work
aims
to
elucidate,
using
a
meta-analytical
and
systematic
review
approach,
effects
different
doses
forms
(Zn)
on
health,
performance,
gut
health
weaning
pigs.
A
total
309
articles
were
identified
from
literature
research
2001
2021;
85
selected.
Articles
divided
in
3
datasets
evaluate:
1)
ZnO
(ZnO
database);
2)
efficacy
infection
models
(challenge
3)
effect
Zn
sources
(special
database).
experimental
groups
classified
according
their
dose:
low
(LZn:
0–200
ppm);
medium
(M1Zn:
201–630
ppm;
M2Zn:
631–1600
high
(HZn:>1601
ppm).
Dataset
2
analysed
by
approach.
Results
showed
that
M1Zn
M2Zn
guarantee
comparable
average
daily
gain,
villus
height
crypt
depth
HZn.
HZn
group
had
higher
Escherichia
coli
(p
=
0.04)
small
intestine.
database
confirmed
between
600
1600
ppm
results
intestinal
function
growth
performance
pharmacological
Zn.
challenge
dataset
positive
counteracting
infections
resulting
lower
diarrhoea
better
morphology.
special
suggested
coated,
capsulated
nano
represent
most
promising
alternative
reduce
detrimental
Animals,
Год журнала:
2023,
Номер
14(1), С. 146 - 146
Опубликована: Дек. 31, 2023
High
dose
of
zinc
oxide
(ZnO)
could
improve
growth
performance
and
alleviate
disease
status,
whereas
it
caused
serious
environmental
pollution
bacterial
resistance.
This
study
was
to
investigate
whether
low
doses
sodium
alginate-coated
nano
(saZnO),
a
new
type
resource,
serve
as
potential
alternative
pharmacological
traditional
ZnO
in
weaned
piglets.
A
total
144
crossbred
piglets
were
randomly
allocated
into
three
groups,
including
basal
diet
without
the
addition
Zn
(CON),
with
1600
mg
Zn/kg
from
(ZnO),
500
saZnO
(saZnO).
The
experiment
lasted
for
28
days.
results
showed
that
supplementing
14
days
significantly
improved
body
weight
(BW)
average
daily
gain
(ADG)
(p
<
0.01)
markedly
reduced
feed
intake-to-gain
ratio
(F/G)
0.05)
diarrhea
rate.
In
addition,
dietary
increased
activities
antioxidant
capacity
(T-AOC)
alkaline
phosphatase
(ALP)
0.01).
Supplementing
also
promoted
levels
superoxide
dismutase
(SOD),
IgM
copper-
zinc-containing
(Cu/Zn-SOD)
serum
0.05),
decreased
concentration
malondialdehyde
(MDA)
indicating
beneficial
effect
on
immune
functions.
Piglets
fed
higher
accumulations
than
those
CON
diets
at
d
0.01),
contributed
excretion
feces,
especially
Additionally,
had
greater
valeric
acid
concentrations
their
while
other
short
chain
fatty
acids
(SCFAs)
not
affected
by
different
treatments
>
0.05).
Microbial
alpha
diversity
group
compared
an
obvious
separation
microbial
composition,
marker
beta
diversity,
shown
among
groups
At
genus
level,
six
genera,
Clostridium_sensu_stricto_1,
Terrisporobacter,
f_Muribaculaceae,
Subdoligranulum
Intestinibacter,
pronouncedly
0.05);
another
nine
species
dramatically
downregulated,
such
f_Lachnospiraceae,
f_Prevotellaceae,
f_Butyricicoccaceae
f_Ruminococcaceae
Finally,
functional
analysis
indicated
altered
microbes
changed
“Metabolism”
pathway
These
findings
suggested
act
feasible
substitute
reduce
emission
enhance
performance,
functions,
adjust
structure
gut
microbiota
Italian Journal of Animal Science,
Год журнала:
2024,
Номер
23(1), С. 241 - 258
Опубликована: Фев. 7, 2024
In
the
European
Union,
withdrawal
of
pharmaceutical
zinc
oxide
(ZnO)
poses
challenges
for
post-weaning
pigs
management.
The
present
work
aims
to
elucidate,
using
a
meta-analytical
and
systematic
review
approach,
effects
different
doses
forms
(Zn)
on
health,
performance,
gut
health
weaning
pigs.
A
total
309
articles
were
identified
from
literature
research
2001
2021;
85
selected.
Articles
divided
in
3
datasets
evaluate:
1)
ZnO
(ZnO
database);
2)
efficacy
infection
models
(challenge
3)
effect
Zn
sources
(special
database).
experimental
groups
classified
according
their
dose:
low
(LZn:
0–200
ppm);
medium
(M1Zn:
201–630
ppm;
M2Zn:
631–1600
high
(HZn:>1601
ppm).
Dataset
2
analysed
by
approach.
Results
showed
that
M1Zn
M2Zn
guarantee
comparable
average
daily
gain,
villus
height
crypt
depth
HZn.
HZn
group
had
higher
Escherichia
coli
(p
=
0.04)
small
intestine.
database
confirmed
between
600
1600
ppm
results
intestinal
function
growth
performance
pharmacological
Zn.
challenge
dataset
positive
counteracting
infections
resulting
lower
diarrhoea
better
morphology.
special
suggested
coated,
capsulated
nano
represent
most
promising
alternative
reduce
detrimental
