Evaluation Anti-porcine Reproductive and Respiratory Syndrome Virus Activity of Bacillus Strains
Abstract
Porcine
reproductive
and
respiratory
syndrome
virus
(PRRSV)
is
a
major
pathogen
in
the
swine
industry,
causing
severe
issues
pigs
leading
to
substantial
economic
losses
worldwide.
This
study
investigates
antiviral
potential
of
three
Bacillus
strains—Bacillus
amyloliquefaciens
LN,
Bacillus
licheniformis
CK,
velezensis
AC—against
PRRSV
using
MARC-145
cell
model.
All
strains
demonstrated
significant
prophylactic
direct-inhibitory
effects
against
PRRSV,
primarily
through
inhibition
viral
attachment
internalization,
reduction
intracellular
extracellular
loads.
Notably,
cell-wall
fraction
AC
upregulated
type
I
IFN-dependent
genes,
including
interferon-stimulated
gene
15
(ISG15),
myxovirus
resistance
2
(Mx2),
2'-5'-oligoadenylate
synthetase
1
(OAS1).
Additionally,
all
significantly
reduced
interleukin
(IL)-8
expression,
with
reductions
tumor
necrosis
factor
(TNF)-α
levels
observed
specific
treatments,
highlighting
their
immune-modulatory
effects.
These
findings
suggest
that
have
as
agents
offering
alternative
strategies
for
managing
infections
populations.
Research Square (Research Square), Год журнала: 2024, Номер unknown
Опубликована: Ноя. 18, 2024
Язык: Английский