Neighborhood environment and cognitive functioning in middle-aged and older population: A mediating role of physical activity

International Journal of Hygiene and Environmental Health, Год журнала: 2025, Номер 264, С. 114521 - 114521

Опубликована: Янв. 13, 2025

Evidence on the impact of complex neighborhood environment, including air pollution, greenness, and socioeconomic deprivation (nSED) cognitive health in older adults remains scarce. Both cognition environment are associated with physical activity, but little is known about potential mediating role activity this association. Cross-sectional data Czech arm HAPIEE cohort study examined 4,178 participants (55.6% women) aged 45-69 years. Global score was constructed from memory, verbal fluency, concentration domains. The exposures, assigned to participant's addresses, include 4-year (2000-2003) average concentrations PM2.5, greenness index calculated tree crown canopy cover estimation (2000), census-based nSED characteristics. Physical other covariates were assessed by a questionnaire. Structural equation modelling used estimate standardized β coefficients for relationships between performance. After controlling range covariates, global function inversely PM2.5 (β = -0.087; 95%CI: 0.122 -0.052) -0.147; 0.182 -0.115), positively 0.036; 0.001 0.069). We identified weak statistically significant associations exposures score. Total mediation proportions ranged 3.9% 6.5% respectively. individuals; partially mediated activity.

Язык: Английский

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Temporal distribution of environmental pollutants in high-occupancy buildings transitional spaces and exposure risk assessment for different flow paths

Building and Environment, Год журнала: 2025, Номер unknown, С. 112840 - 112840

Опубликована: Март 1, 2025

Язык: Английский

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High-Resolution Tracking of Aging-Related Small Molecules: Bridging Pollutant Exposure, Brain Aging Mechanisms, and Detection Innovations

Biosensors, Год журнала: 2025, Номер 15(4), С. 242 - 242

Опубликована: Апрель 11, 2025

Brain aging is a complex process regulated by genetic, environmental, and metabolic factors, increasing evidence suggests that environmental pollutants can significantly accelerate this interfering with oxidative stress, neuroinflammation, mitochondrial function-related signaling pathways. Traditional studies have focused on the direct damage of macromolecules (e.g., proteins, DNA), while central role senescence-associated small molecules ROS, PGE2, lactate) in early regulatory mechanisms has been long neglected. In study, we innovatively proposed cascade framework "small molecule imbalance-signaling pathway dysregulation-macromolecule collapse", which reveals exacerbate dynamics brain through activation NLRP3 inflammatory vesicles inhibition HIF-1α. Meanwhile, to address technical bottleneck spatiotemporal monitoring, paper systematically reviews cutting-edge detection tools such as electrochemical sensors, genetically encoded fluorescent probes antioxidant quantum dots (AQDs). Among them, AQDs show unique advantages real-time monitoring ROS fluctuations intervention virtue their ultra-high specific surface area, controllable modification, free radical scavenging ability. By integrating multimodal techniques mechanism studies, work provides new perspective for analyzing pollutant-induced lays methodological foundation strategies based networks.

Язык: Английский

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Co-exposure to ozone and polystyrene nanoplastic exacerbates cognitive impairment and anxiety-like behavior by regulating neuronal pyroptosis in mice

Environment International, Год журнала: 2025, Номер 199, С. 109501 - 109501

Опубликована: Апрель 25, 2025

Ozone (O3) and nanoplastics (NPs) are pervasive environmental pollutants that frequently co-occur in our heavily industrialized era. While it has been documented exposure to O3 or NPs individually neurotoxic effects, studies investigating their combined impact the hazardous mechanisms resulting from co-exposure limited. In this study, we established a mouse model polystyrene nanoparticles (PS-NPs) O3, focusing on prefrontal cortex (PFC), brain region crucial for cognition emotion. We examined effects of PS-NPs behavioral changes related learning, memory, anxiety, employing transcriptome sequencing alongside molecular histopathological methods. Our findings indicate disrupts integrity blood-brain barrier, reducing Claudin 5 expression leading increased accumulation PFC. Transcriptome demonstrated involvement p38 mitogen-activated protein kinase (p38 MAPK) signaling pathway oxidative stress pathological observed Through immunohistochemical immunofluorescence analysis, enhanced microglial activation, which correlates with production inflammatory factors. Additionally, western blot co-labeling analyses revealed elevated levels GSDMD-N, caspase-1, IL-1β, IL-18 proteins, associated neuronal pyroptosis. Finally, confirmed activation MAPK neurons is involved co-exposure-induced Meanwhile, N-Acetylcysteine (NAC), common antioxidant, can alleviate neuroinflammation pyroptosis PFC, rescued cognitive deficits anxiety-like behaviors co-exposed mice. study illustrates aggravate damage barrier elevate thereby increasing occurrence may mediate through pathway, ultimately contributing neurobehavioral toxicity.

Язык: Английский

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Brain iron accumulation in neurodegenerative disorders: Does air pollution play a role?

Particle and Fibre Toxicology, Год журнала: 2025, Номер 22(1)

Опубликована: Май 1, 2025

Both excess brain Fe and air pollution (AP) exposures are associated with increased risk for multiple neurodegenerative disorders. is a redox-active metal that abundant in AP even further elevated U.S. subway systems. Exposures to contaminants, such as Fe, lifelong could therefore contribute observed diseases, particularly via nasal olfactory uptake of ultrafine particle AP. These studies tested the hypotheses exogenously generated oxide nanoparticles reach following inhalational produce neurotoxic effects consistent diseases disorders adult C57/Bl6J mice exposed by inhalation at concentration similar those found underground systems (~ 150 µg/m3) 20 days. Olfactory bulb sections exposure chamber TEM grids were analyzed speciation. Measures included volumetric diffusivity changes; levels striatal cerebellar neurotransmitters trans-sulfuration markers; quantification frontal cortical hippocampal Aβ42, total tau, phosphorylated tau; behavioral alterations locomotor activity memory. Particle speciation confirmed similarity oxides (mostly magnetite) on bulb. Alzheimer's disease (AD) like characteristics seen Fe-exposed females including diffusivity, impaired memory, accumulation tau significantly correlated errors radial arm maze. males showed volume substantia nigra pars compacta, region critical motor impairments Parkinson's (PD), conjunction reduced trigeminal nerve optic tract chiasm. Inhaled appeared lead uptake. Further, these reproduced characteristic features sex-dependent manner, evidencing AD regions PD. As such, prolonged inhaled should be considered source aging, factor diseases. The bases dichotomous sex yet unclear. Also unknown how duration affect outcome, and/or whether during early development enhances vulnerability subsequent exposures. Collectively, findings suggest regulation levels, enclosed areas stations, may have broad public health protective effects.

Язык: Английский

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Concentration distribution and group disparity of traffic-derived NO₂ exposure in Baoshan District

Carbon Footprints, Год журнала: 2025, Номер 4(3)

Опубликована: Май 21, 2025

Motor vehicles are a major source of NO2 emissions, making traffic-related pollution key target for urban air control management. However, research on exposure risks in China remains nascent, particularly regarding spatio-temporal variations and inequities. To support evidence-based public health policies, it is essential to investigate group disparities across both spatial temporal dimensions. This study utilizes the CALPUFF model mobile phone signal data examine patterns population within Baoshan District, Shanghai, China. The findings reveal bimodal diurnal pattern, with higher levels weekdays lower weekends. Areas heavy traffic high density, such as port zones outer ring expressway, identified most vulnerable. Furthermore, males younger age groups experience greater NO2, whereas elderly individuals comparatively less exposed.

Язык: Английский

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Association between ambient air pollutants and short-term mortality risks during 2015–2019 in Guangzhou, China

Frontiers in Public Health, Год журнала: 2024, Номер 12

Опубликована: Март 4, 2024

With the development of technology and industry, problem global air pollution has become difficult to ignore. We investigated association between pollutant concentrations daily all-cause mortality stratified analysis by sex, age, season. Data for six pollutants [fine particulate matter (PM 2.5 ), inhalable particles 10 nitric dioxide (NO 2 sulfur (SO ozone (O 3 carbon monoxide (CO)] rates were collected from 2015 2019 in Guangzhou, China. A time-series study using a quasi-Poisson generalized additive model was used examine relationships environmental mortality. Mortality data 296,939 individuals included analysis. The results showed that an increase μg/m PM , SO O NO CO corresponded 0.84% [95% confidence interval (CI): 0.47, 1.21%], 0.70% (0.44, 0.96%), 3.59% (1.77, 5.43%), 0.21% (0.05, 0.36%), 1.06% (0.70, 1.41%), 0.05% (0.02, 0.09%), respectively. effects more significant male than female individuals, cool season warm season, people 75 years or older those younger years. all associated with neoplasms circulatory respiratory diseases. two-pollutant models found may independently affect risk exposure excessive Guangzhou.

Язык: Английский

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Association between pain, sleep and intrinsic capacity in Chinese older adults: Evidence from CHARLS

The journal of nutrition health & aging, Год журнала: 2024, Номер 29(3), С. 100466 - 100466

Опубликована: Дек. 31, 2024

Язык: Английский

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Particulate Matter in Human Elderly: Higher Susceptibility to Cognitive Decline and Age-Related Diseases

Biomolecules, Год журнала: 2023, Номер 14(1), С. 35 - 35

Опубликована: Дек. 26, 2023

This review highlights the significant impact of air quality, specifically particulate matter (PM), on cognitive decline and age-related diseases in elderly. Despite established links to other pathologies, such as respiratory cardiovascular illnesses, there is a pressing need for increased attention association between pollution aging, given rising prevalence neurocognitive disorders. PM sources are from diverse origins, including industrial activities combustion engines, categorized into

Язык: Английский

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Extreme temperature events, functional dependency, and cardiometabolic multimorbidity: Insights from a national cohort study in China

Ecotoxicology and Environmental Safety, Год журнала: 2024, Номер 284, С. 117013 - 117013

Опубликована: Сен. 6, 2024

Язык: Английский

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