What are the consequences of PM air pollution exposure on elderly behavior? A systematic review

Environmental Pollution, Journal Year: 2025, Volume and Issue: unknown, P. 126279 - 126279

Published: April 1, 2025

Language: Английский

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Brain iron accumulation in neurodegenerative disorders: Does air pollution play a role?

Particle and Fibre Toxicology, Journal Year: 2025, Volume and Issue: 22(1)

Published: May 1, 2025

Both excess brain Fe and air pollution (AP) exposures are associated with increased risk for multiple neurodegenerative disorders. is a redox-active metal that abundant in AP even further elevated U.S. subway systems. Exposures to contaminants, such as Fe, lifelong could therefore contribute observed diseases, particularly via nasal olfactory uptake of ultrafine particle AP. These studies tested the hypotheses exogenously generated oxide nanoparticles reach following inhalational produce neurotoxic effects consistent diseases disorders adult C57/Bl6J mice exposed by inhalation at concentration similar those found underground systems (~ 150 µg/m3) 20 days. Olfactory bulb sections exposure chamber TEM grids were analyzed speciation. Measures included volumetric diffusivity changes; levels striatal cerebellar neurotransmitters trans-sulfuration markers; quantification frontal cortical hippocampal Aβ42, total tau, phosphorylated tau; behavioral alterations locomotor activity memory. Particle speciation confirmed similarity oxides (mostly magnetite) on bulb. Alzheimer's disease (AD) like characteristics seen Fe-exposed females including diffusivity, impaired memory, accumulation tau significantly correlated errors radial arm maze. males showed volume substantia nigra pars compacta, region critical motor impairments Parkinson's (PD), conjunction reduced trigeminal nerve optic tract chiasm. Inhaled appeared lead uptake. Further, these reproduced characteristic features sex-dependent manner, evidencing AD regions PD. As such, prolonged inhaled should be considered source aging, factor diseases. The bases dichotomous sex yet unclear. Also unknown how duration affect outcome, and/or whether during early development enhances vulnerability subsequent exposures. Collectively, findings suggest regulation levels, enclosed areas stations, may have broad public health protective effects.

Language: Английский

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Concentration distribution and group disparity of traffic-derived NO₂ exposure in Baoshan District

Carbon Footprints, Journal Year: 2025, Volume and Issue: 4(3)

Published: May 21, 2025

Motor vehicles are a major source of NO2 emissions, making traffic-related pollution key target for urban air control management. However, research on exposure risks in China remains nascent, particularly regarding spatio-temporal variations and inequities. To support evidence-based public health policies, it is essential to investigate group disparities across both spatial temporal dimensions. This study utilizes the CALPUFF model mobile phone signal data examine patterns population within Baoshan District, Shanghai, China. The findings reveal bimodal diurnal pattern, with higher levels weekdays lower weekends. Areas heavy traffic high density, such as port zones outer ring expressway, identified most vulnerable. Furthermore, males younger age groups experience greater NO2, whereas elderly individuals comparatively less exposed.

Language: Английский

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Spatiotemporal Weighted for Improving the Satellite-Based High-Resolution Ground PM2.5 Estimation Using the Light Gradient Boosting Machine

Remote Sensing, Journal Year: 2023, Volume and Issue: 15(16), P. 4104 - 4104

Published: Aug. 21, 2023

Surface fine particulate matter (PM) with a diameter of less than 2.5 microns (PM2.5) negatively impacts human health and the economy. However, due to data model limitations, obtaining high-quality, high-spatial-resolution surface PM2.5 concentration is challenging task, it difficult accurately assess temporal spatial changes in levels at small regional scale. Here, we combined multi-angle implementation atmospheric correction (MAIAC) aerosol products, ERA5 reanalysis data, etc., construct an STW-LightGBM that considers spatiotemporal characteristics air pollution estimate China’s 1 km resolution from 2015 2020. Our performed well, fitting accuracy 10-fold cross-validation between years was 0.877–0.917. The >0.85 different time scales (month, season, year). average slope regression prediction 0.9 annually. results showed improved decreased by 4.55 μg/m3, maximum decrease reached 90.51 μg/m3. areas high concentrations were predominantly North China Plain, Sichuan Basin, Xinjiang west, elevated consistent across most study years. standard deviation ellipse for ‘northeast–southwest’ distribution. From interannual perspective, values four seasonal stations country downward trend 2020, obvious decline winter, 70.67 μg/m3 46.75 Compared earlier inversion studies, this work provides more stable accurate method high-resolution which necessary local governance environmental ecological construction

Language: Английский

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Moderate BMI accumulation modified associations between blood benzene, toluene, ethylbenzene and xylene (BTEX) and phenotypic aging: mediating roles of inflammation and oxidative stress

Environmental Pollution, Journal Year: 2024, Volume and Issue: 360, P. 124669 - 124669

Published: Aug. 3, 2024

Language: Английский

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Association between pain, sleep and intrinsic capacity in Chinese older adults: Evidence from CHARLS

The journal of nutrition health & aging, Journal Year: 2024, Volume and Issue: 29(3), P. 100466 - 100466

Published: Dec. 31, 2024

Language: Английский

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High-Resolution Tracking of Aging-Related Small Molecules: Bridging Pollutant Exposure, Brain Aging Mechanisms, and Detection Innovations

Biosensors, Journal Year: 2025, Volume and Issue: 15(4), P. 242 - 242

Published: April 11, 2025

Brain aging is a complex process regulated by genetic, environmental, and metabolic factors, increasing evidence suggests that environmental pollutants can significantly accelerate this interfering with oxidative stress, neuroinflammation, mitochondrial function-related signaling pathways. Traditional studies have focused on the direct damage of macromolecules (e.g., proteins, DNA), while central role senescence-associated small molecules ROS, PGE2, lactate) in early regulatory mechanisms has been long neglected. In study, we innovatively proposed cascade framework "small molecule imbalance-signaling pathway dysregulation-macromolecule collapse", which reveals exacerbate dynamics brain through activation NLRP3 inflammatory vesicles inhibition HIF-1α. Meanwhile, to address technical bottleneck spatiotemporal monitoring, paper systematically reviews cutting-edge detection tools such as electrochemical sensors, genetically encoded fluorescent probes antioxidant quantum dots (AQDs). Among them, AQDs show unique advantages real-time monitoring ROS fluctuations intervention virtue their ultra-high specific surface area, controllable modification, free radical scavenging ability. By integrating multimodal techniques mechanism studies, work provides new perspective for analyzing pollutant-induced lays methodological foundation strategies based networks.

Language: Английский

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Association between ambient air pollutants and short-term mortality risks during 2015–2019 in Guangzhou, China

Frontiers in Public Health, Journal Year: 2024, Volume and Issue: 12

Published: March 4, 2024

With the development of technology and industry, problem global air pollution has become difficult to ignore. We investigated association between pollutant concentrations daily all-cause mortality stratified analysis by sex, age, season. Data for six pollutants [fine particulate matter (PM 2.5 ), inhalable particles 10 nitric dioxide (NO 2 sulfur (SO ozone (O 3 carbon monoxide (CO)] rates were collected from 2015 2019 in Guangzhou, China. A time-series study using a quasi-Poisson generalized additive model was used examine relationships environmental mortality. Mortality data 296,939 individuals included analysis. The results showed that an increase μg/m PM , SO O NO CO corresponded 0.84% [95% confidence interval (CI): 0.47, 1.21%], 0.70% (0.44, 0.96%), 3.59% (1.77, 5.43%), 0.21% (0.05, 0.36%), 1.06% (0.70, 1.41%), 0.05% (0.02, 0.09%), respectively. effects more significant male than female individuals, cool season warm season, people 75 years or older those younger years. all associated with neoplasms circulatory respiratory diseases. two-pollutant models found may independently affect risk exposure excessive Guangzhou.

Language: Английский

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Diurnal temperature range and hypertension: cross-sectional and longitudinal findings from the China Health and Retirement Longitudinal Study (CHARLS)

BMC Public Health, Journal Year: 2024, Volume and Issue: 24(1)

Published: Sept. 30, 2024

Language: Английский

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Associations of ambient particulate matter and household fuel use with chronic liver disease in China: A nationwide analysis

Environment International, Journal Year: 2024, Volume and Issue: 193, P. 109083 - 109083

Published: Oct. 23, 2024

Language: Английский

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