Polystyrene microplastics disrupt female reproductive health and fertility via sirt1 modulation in zebrafish (Danio rerio)

Journal of Hazardous Materials, Год журнала: 2023, Номер 460, С. 132359 - 132359

Опубликована: Авг. 22, 2023

Язык: Английский

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Perfluorooctane sulfonate causes pyroptosis and lipid metabolism disorders through ROS-mediated NLRP3 inflammasome activation in grass carp hepatocyte

Aquatic Toxicology, Год журнала: 2024, Номер 267, С. 106839 - 106839

Опубликована: Янв. 15, 2024

Язык: Английский

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Effects of developmental exposure to individual and combined PFAS on development and behavioral stress responses in larval zebrafish

Environmental Pollution, Год журнала: 2024, Номер 349, С. 123912 - 123912

Опубликована: Апрель 1, 2024

Язык: Английский

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An insight into the molecular mechanisms of persistent organic pollutants (POPs) mediated dysregulation of glucose and lipid homeostasis in Heteropneustes fossilis

General and Comparative Endocrinology, Год журнала: 2025, Номер unknown, С. 114670 - 114670

Опубликована: Янв. 1, 2025

Язык: Английский

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Hydroxylase-like Biomimetic Nanozyme Synthesized via a Urea-Mediated MOF Pyrolytic Reconstruction Strategy for Non-“o-Phenol hydroxyl”-Dependent Dopamine Electrochemical Sensing

Analytical Chemistry, Год журнала: 2024, Номер 96(15), С. 6037 - 6044

Опубликована: Апрель 1, 2024

Dopamine (DA), an essential neurotransmitter, is closely associated with various neurological disorders, whose real-time dynamic monitoring significant for evaluating the physiological activities of neurons. Electrochemical sensing methods are commonly used to determine DA, but they mostly rely on redox reaction its o-phenolic hydroxyl group, which makes it difficult distinguish from substances this group. Here, we design a biomimetic nanozyme inspired by coordination structure copper-based active site dopamine β-hydroxylase, was successfully synthesized via urea-mediated MOF pyrolysis reconstruction strategy. Experimental studies and theoretical calculations revealed that Cu–N3 could hydroxylate carbon atom DA β-site at suitable potential sites have lowest binding energy β-site. With property, new oxidation peak achieves specific detection rather than traditional electrochemical signal o-phenol redox, would effectively differentiate neurotransmitters, such as norepinephrine epinephrine. The sensor exhibited good capability in concentrations 0.05 16.7 μM, limit 0.03 μM. Finally, enables released living cells can be quantitatively analyze effect polystyrene microplastics amount released. research provides method highly technical support initial screening neurocytotoxicity pollutants.

Язык: Английский

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Hepatotoxic response of perfluorooctane sulfonamide (PFOSA) in early life stage zebrafish (Danio rerio) is greater than perfluorooctane sulfonate (PFOS)

Journal of Hazardous Materials, Год журнала: 2023, Номер 461, С. 132552 - 132552

Опубликована: Сен. 14, 2023

Язык: Английский

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Embryonic Ethanol Exposure Induces Oxidative Stress and Inflammation in Zebrafish Model: A Dose-Dependent Study

Toxicology, Год журнала: 2024, Номер 506, С. 153876 - 153876

Опубликована: Июнь 28, 2024

Язык: Английский

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Enviromental endocrine disruptor risks in the central nervous system: Neurotoxic effects of PFOS and glyphosate

Environmental Toxicology and Pharmacology, Год журнала: 2024, Номер 109, С. 104496 - 104496

Опубликована: Июль 2, 2024

Endocrine disruptors (EDs) pose significant risks to human and environmental health, with potential implications for neurotoxicity. This study investigates the synergistic neurotoxic effects of perfluorooctane sulfonate (PFOS) glyphosate (GLY), two ubiquitous EDs, using SHSY5Y neuronal C6 astrocytic cell lines. While individual exposures PFOS at non-toxic concentrations did not induce changes, their combination resulted in a marked increase oxidative stress neuroinflammatory responses. Specifically, co-exposure led elevated levels interleukin-6, tumor necrosis factor alpha, interferon gamma, along reduced interleukin-10 expression, indicative heightened processes. These findings underscore importance considering interactions EDs assessing highlight urgent need further research mitigate adverse these compounds on neurological health.

Язык: Английский

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Neurobehavioral Response in Zebrafish Exposed to Perfluorooctane Sulfonate and its Substitutes: Underestimated Ecological Risks

Опубликована: Янв. 1, 2025

Язык: Английский

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Microglial Regulation of Neural Networks in Neuropsychiatric Disorders

The Neuroscientist, Год журнала: 2025, Номер unknown

Опубликована: Фев. 11, 2025

Microglia serve as vital innate immune cells in the central nervous system, playing crucial roles generation and development of brain neurons, well mediating a series inflammatory responses. The morphologic transitions microglia are closely linked to their function. With advent single-cell sequencing technology, diversity microglial subtypes is increasingly recognized. intricate interactions between neuronal networks have significant implications for psychiatric disorders neurodegenerative diseases. A deeper investigation neurologic diseases such Alzheimer disease, depression, epilepsy can provide valuable insights understanding pathogenesis exploring novel therapeutic strategies, thereby addressing issues related system disorders.

Язык: Английский

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