Toxicology Research,
Год журнала:
2024,
Номер
13(6)
Опубликована: Ноя. 5, 2024
Nanoplastics
(NPs)
can
penetrate
the
intestinal
barrier
of
organisms
and
accumulate
in
liver,
thereby
inducing
hepatocyte
apoptosis.
However,
underlying
mechanisms
remain
incompletely
elucidated.
This
study
examined
effects
PS-NPs
exposure
on
apoptosis
revealed
role
cell
cycle
arrest
mitophagy.
The
C57BL/6
mice
were
administered
a
diet
containing
100
nm
500
at
concentration
0.1
g/kg
for
180
days,
respectively.
TUNEL
staining
confirmed
that
induced
more
pronounced
compared
to
mouse
liver.
Mechanistically,
proteomic
analysis
Pdcd2l,
associated
with
S
phase
apoptosis,
exhibited
highest
fold
changes
among
all
detected
proteins
groups.
Notably,
expression
Tbc1d17,
Bcl2l13,
Pgam5
involved
mitophagosome
formation
liver
was
upregulated
by
but
not
PS-NPs;
moreover,
mitophagosomes
observed
HepG2
cells
exposed
PS-NPs.
Additionally,
internalized
could
lysosomes.
protein
levels
Igf2r
Rab7a
altered,
Poultry Science,
Год журнала:
2024,
Номер
103(6), С. 103674 - 103674
Опубликована: Март 16, 2024
Microplastics
biological
toxicity,
environmental
persistence
and
chemicals
have
been
paid
widespread
attention.
exposed
to
chicken
spleen
injury
of
the
specific
mechanism
is
unclear.
Thus,
we
randomly
assigned
chickens
4
groups:
C
(normal
diet),
L-MPs
(1
mg/L),
M-MPs
(10
H-MPs
(100
assessed
damage
after
42
d
exposure.
Morphologically,
boundary
between
red
white
pulp
was
blurred,
along
with
expansion
pulp.
It
further
speculated
that
microplastics
induced
mitochondrial
dynamic
homeostasis
(Drp1
upgraded,
Mfn1,
Mfn2,
OPA1
reduced),
provoked
apoptotic
pathway
(Bcl-2/Bax
decreased,
cytc,
caspase3,
caspase9
raised),
resulting
in
redox
imbalance
lipid
peroxide
accumulation
(MDA
increased,
CAT,
GSH,
T-AOC
plummeted),
stimulated
ferroptosis
(FTH1,
GPX4,
SLC7A11
decreased).
Here
explored
impact
polystyrene
on
spleen,
as
well
programmed
death
(apoptosis
ferroptosis)
involved,
regulative
role
mitochondria
this
process.
This
could
be
significant
importance
bridging
gap
laboratory
research
microplastics-induced
chicken.
Environment International,
Год журнала:
2023,
Номер
183, С. 108380 - 108380
Опубликована: Дек. 11, 2023
Gastrointestinal
diseases
exert
a
profound
impact
on
global
health,
leading
to
millions
of
healthcare
interventions
and
significant
number
fatalities
annually.
This,
coupled
with
escalating
expenditures,
underscores
the
need
for
identifying
addressing
potential
exacerbating
factors.
One
emerging
concern
is
pervasive
presence
microplastics
nano-plastics
in
environment,
largely
attributed
indiscriminate
usage
disposable
plastic
items.
These
nano-plastics,
having
infiltrated
our
food
chain,
pose
threat
gastrointestinal
health.
To
understand
this
better,
we
co-cultured
human
gastric
fibroblasts
(HGF)
polystyrene
(PS-NPs)
diverse
sizes
(80,
500,
650
nm)
meticulously
investigated
their
cellular
responses
over
24-hour
period.
Our
findings
revealed
PS
particles
were
ingested
by
cells,
notable
increase
ingestion
as
particle
size
decreased.
The
death
induced
these
particles,
encompassing
both
apoptosis
necrosis,
showcased
clear
dependence
its
concentration.
Notably,
larger
manifested
more
potent
cytotoxic
effects.
Further
analysis
indicated
concerning
reduction
membrane
potential,
alongside
marked
ROS
levels
upon
exposure.
This
suggests
disruption
mitochondrial
function
heightened
oxidative
stress.
especially
detrimental
causing
dysfunction.
In-depth
exploration
into
genes
linked
permeability
transition
pore
(PTP)
elucidated
that
instigated
an
internal
calcium
rush.
surge
led
compromise
which
tandem
raised
levels,
further
catalyzed
DNA
damage
initiated
cell
pathways.
In
essence,
study
unveils
intricate
mechanisms
underpinning
caused
epithelial
cells
highlighting
implications
revelations
from
research
bear
shape
future
strategies
inform
pertinent
environmental
policies.
Environmental Toxicology and Chemistry,
Год журнала:
2025,
Номер
44(2), С. 470 - 483
Опубликована: Янв. 6, 2025
Nanoplastics
(NPs)
and
neonicotinoids
are
common
pollutants
in
aquatic
ecosystems.
Although
their
co-occurrence
is
expected
multiple
environments,
studies
assessing
combined
effects
still
limited.
This
toxicological
assessment
investigated
the
potential
of
polystyrene
NPs
(PSNPs),
clothianidin
(CLO),
mixtures
on
four
species:
freshwater
cladoceran
Daphnia
magna,
duckweed
Lemna
minor,
green
algae
Chlamydomonas
reinhardtii,
cyanobacteria
Microcystis
aeruginosa.
Toxicological
tests
were
performed
following
International
Organization
for
Standardization
Organisation
Economic
Co-operation
Development
protocols.
Acute,
chronic
(multigenerational)
swimming
behavior
with
D.
growth
inhibition
run
L.
C.
M.
Abbott's
model
was
used
to
predict
interactions
each
one
tested
species.
The
magna
immobility
revealed
that
toxicities
PSNPs
CLO
decreased
when
compounds
present
as
a
mixture.
Antagonistic
also
observed
reinhardtii
growth,
whereas
minor
aeruginosa,
ranged
from
antagonism
additivity.
Chronic
multigenerational
neonates
obtained
exposed
parental
generation
showed
delay
first
brood
during
recovery
(nonexposure)
phase,
but
this
effect
disappeared
at
next
generation,
which
indicates
microcrustaceans
will
probably
be
able
recover
long-term
scale
if
contamination
stopped.
Our
results
provide
new
insights
into
toxicity
ecological
risk
toward
organisms.
