Proteomics reveals that nanoplastics with different sizes induce hepatocyte apoptosis in mice through distinct mechanisms involving mitophagy dysregulation and cell cycle arrest DOI

Yanyang Lu,

Weizhen Hua,

Yiqiong Sun

и другие.

Toxicology Research, Год журнала: 2024, Номер 13(6)

Опубликована: Ноя. 5, 2024

Nanoplastics (NPs) can penetrate the intestinal barrier of organisms and accumulate in liver, thereby inducing hepatocyte apoptosis. However, underlying mechanisms remain incompletely elucidated. This study examined effects PS-NPs exposure on apoptosis revealed role cell cycle arrest mitophagy. The C57BL/6 mice were administered a diet containing 100 nm 500 at concentration 0.1 g/kg for 180 days, respectively. TUNEL staining confirmed that induced more pronounced compared to mouse liver. Mechanistically, proteomic analysis Pdcd2l, associated with S phase apoptosis, exhibited highest fold changes among all detected proteins groups. Notably, expression Tbc1d17, Bcl2l13, Pgam5 involved mitophagosome formation liver was upregulated by but not PS-NPs; moreover, mitophagosomes observed HepG2 cells exposed PS-NPs. Additionally, internalized could lysosomes. protein levels Igf2r Rab7a altered,

Язык: Английский

Polystyrene nanoplastics-induced lung apoptosis and ferroptosis via ROS-dependent endoplasmic reticulum stress DOI
Qiumei Wu, Chao Liu, Dan Liu

и другие.

The Science of The Total Environment, Год журнала: 2023, Номер 912, С. 169260 - 169260

Опубликована: Дек. 10, 2023

Язык: Английский

Процитировано

45

Biological exposure to microplastics and nanoplastics and plastic additives: impairment of glycolipid metabolism and adverse effects on metabolic diseases DOI

Peng Chen Zheng,

Rong Li, Keng Po Lai

и другие.

Environmental Science and Pollution Research, Год журнала: 2024, Номер 31(51), С. 60778 - 60791

Опубликована: Окт. 16, 2024

Язык: Английский

Процитировано

9

Polystyrene nanoplastics induce lipophagy via the AMPK/ULK1 pathway and block lipophagic flux leading to lipid accumulation in hepatocytes DOI

Zhuying Fan,

Yukang Zhang,

Yuting Fang

и другие.

Journal of Hazardous Materials, Год журнала: 2024, Номер 476, С. 134878 - 134878

Опубликована: Июнь 12, 2024

Язык: Английский

Процитировано

8

New insights into the spleen injury by mitochondrial dysfunction of chicken under polystyrene microplastics stress DOI Creative Commons

Tiantian Guo,

Xiren Geng,

Yue Zhang

и другие.

Poultry Science, Год журнала: 2024, Номер 103(6), С. 103674 - 103674

Опубликована: Март 16, 2024

Microplastics biological toxicity, environmental persistence and chemicals have been paid widespread attention. exposed to chicken spleen injury of the specific mechanism is unclear. Thus, we randomly assigned chickens 4 groups: C (normal diet), L-MPs (1 mg/L), M-MPs (10 H-MPs (100 assessed damage after 42 d exposure. Morphologically, boundary between red white pulp was blurred, along with expansion pulp. It further speculated that microplastics induced mitochondrial dynamic homeostasis (Drp1 upgraded, Mfn1, Mfn2, OPA1 reduced), provoked apoptotic pathway (Bcl-2/Bax decreased, cytc, caspase3, caspase9 raised), resulting in redox imbalance lipid peroxide accumulation (MDA increased, CAT, GSH, T-AOC plummeted), stimulated ferroptosis (FTH1, GPX4, SLC7A11 decreased). Here explored impact polystyrene on spleen, as well programmed death (apoptosis ferroptosis) involved, regulative role mitochondria this process. This could be significant importance bridging gap laboratory research microplastics-induced chicken.

Язык: Английский

Процитировано

7

Polystyrene nanoplastics induce lipid metabolism disorder and alter fatty acid composition in the hepatopancreas of Pacific whiteleg shrimp (Litopenaeus vannamei) DOI
Yiming Li,

Yucong Ye,

Na Rihan

и другие.

The Science of The Total Environment, Год журнала: 2023, Номер 906, С. 167616 - 167616

Опубликована: Окт. 12, 2023

Язык: Английский

Процитировано

17

Polystyrene nanoplastics synergistically exacerbate diclofenac toxicity in embryonic development and the health of adult zebrafish DOI

Karthikeyan Kandaswamy,

Ajay Guru, Siva Prasad Panda

и другие.

Comparative Biochemistry and Physiology Part C Toxicology & Pharmacology, Год журнала: 2024, Номер 281, С. 109926 - 109926

Опубликована: Апрель 17, 2024

Язык: Английский

Процитировано

6

Nano-plastics and gastric health: Decoding the cytotoxic mechanisms of polystyrene nano-plastics size DOI Creative Commons
Mingming Han, Tian Zhu, Ji Liang

и другие.

Environment International, Год журнала: 2023, Номер 183, С. 108380 - 108380

Опубликована: Дек. 11, 2023

Gastrointestinal diseases exert a profound impact on global health, leading to millions of healthcare interventions and significant number fatalities annually. This, coupled with escalating expenditures, underscores the need for identifying addressing potential exacerbating factors. One emerging concern is pervasive presence microplastics nano-plastics in environment, largely attributed indiscriminate usage disposable plastic items. These nano-plastics, having infiltrated our food chain, pose threat gastrointestinal health. To understand this better, we co-cultured human gastric fibroblasts (HGF) polystyrene (PS-NPs) diverse sizes (80, 500, 650 nm) meticulously investigated their cellular responses over 24-hour period. Our findings revealed PS particles were ingested by cells, notable increase ingestion as particle size decreased. The death induced these particles, encompassing both apoptosis necrosis, showcased clear dependence its concentration. Notably, larger manifested more potent cytotoxic effects. Further analysis indicated concerning reduction membrane potential, alongside marked ROS levels upon exposure. This suggests disruption mitochondrial function heightened oxidative stress. especially detrimental causing dysfunction. In-depth exploration into genes linked permeability transition pore (PTP) elucidated that instigated an internal calcium rush. surge led compromise which tandem raised levels, further catalyzed DNA damage initiated cell pathways. In essence, study unveils intricate mechanisms underpinning caused epithelial cells highlighting implications revelations from research bear shape future strategies inform pertinent environmental policies.

Язык: Английский

Процитировано

13

Effect of crowding stress on liver health, gut permeability and gut microbiota of genetically improved farmed tilapia (GIFT, Oreochromis niloticus) DOI
Jian Zhang, Jie Chen, Hui Liang

и другие.

Aquaculture, Год журнала: 2024, Номер 594, С. 741448 - 741448

Опубликована: Авг. 4, 2024

Язык: Английский

Процитировано

5

Individual and combined toxicity of polystyrene nanoplastics and clothianidin toward Daphnia magna, Lemna minor, Chlamydomonas reinhardtii, and Microcystis aeruginosa DOI Creative Commons
Felipe Ogliari Bandeira, Paulo Roger Lopes Alves, Thuanne Braúlio Hennig

и другие.

Environmental Toxicology and Chemistry, Год журнала: 2025, Номер 44(2), С. 470 - 483

Опубликована: Янв. 6, 2025

Nanoplastics (NPs) and neonicotinoids are common pollutants in aquatic ecosystems. Although their co-occurrence is expected multiple environments, studies assessing combined effects still limited. This toxicological assessment investigated the potential of polystyrene NPs (PSNPs), clothianidin (CLO), mixtures on four species: freshwater cladoceran Daphnia magna, duckweed Lemna minor, green algae Chlamydomonas reinhardtii, cyanobacteria Microcystis aeruginosa. Toxicological tests were performed following International Organization for Standardization Organisation Economic Co-operation Development protocols. Acute, chronic (multigenerational) swimming behavior with D. growth inhibition run L. C. M. Abbott's model was used to predict interactions each one tested species. The magna immobility revealed that toxicities PSNPs CLO decreased when compounds present as a mixture. Antagonistic also observed reinhardtii growth, whereas minor aeruginosa, ranged from antagonism additivity. Chronic multigenerational neonates obtained exposed parental generation showed delay first brood during recovery (nonexposure) phase, but this effect disappeared at next generation, which indicates microcrustaceans will probably be able recover long-term scale if contamination stopped. Our results provide new insights into toxicity ecological risk toward organisms.

Язык: Английский

Процитировано

0

Nanoplastics under the charge effect: Unveiling the potential threats to amphibian (Rana nigromaculata) growth, intestinal damage, and microbial ecology DOI
Peng Fang, Shuzi Ye, Zisheng Luo

и другие.

Environmental Pollution, Год журнала: 2025, Номер unknown, С. 126566 - 126566

Опубликована: Май 1, 2025

Язык: Английский

Процитировано

0