The Open Biotechnology Journal,
Год журнала:
2023,
Номер
17(1)
Опубликована: Окт. 10, 2023
Background:
Epidemiological
studies
have
shown
that
elevated
levels
of
air
pollutants
are
associated
with
various
adverse
health
effects,
including
infertility.
Objective:
We
aimed
to
assess
the
protective
effects
aqueous
Urtica
dioica
leaf
extract
against
benzo[a]pyrene
-induced
oxidative
damage
in
mouse
testis.
Methods:
Mice
exposed
were
treated
or
without
for
five
weeks,
and
changes
body
testes
weights,
messenger
RNA
activities
antioxidant
enzymes,
plasma
testosterone
levels,
sperm
characteristics,
testicular
tissue
histology
determined.
Results:
Exposure
remarkably
reduced
testis
expression
activity
increased
lipid
peroxidation,
decreased
count
motility,
affected
morphology
viability,
damaged
seminiferous
tubules.
Treatment
attenuated
stress
by
increasing
genes.
Further,
antioxidative
enzyme
activity,
enhanced
improved
Conclusion:
Aqueous
protects
from
could
potentially
reverse
Frontiers in Public Health,
Год журнала:
2024,
Номер
12
Опубликована: Май 10, 2024
Pollution
is
a
critical
concern
of
modern
society
for
its
heterogeneous
effects
on
human
health,
despite
widespread
lack
awareness.
Environmental
pollutants
promote
several
pathologies
through
different
molecular
mechanisms.
Pollutants
can
affect
the
immune
system
and
related
pathways,
perturbing
regulation
triggering
pro-inflammatory
responses.
The
exposure
to
also
leads
alterations
in
gut
microbiota
with
decreasing
abundance
beneficial
microbes,
such
as
short-chain
fatty
acid-producing
bacteria,
an
overgrowth
species.
subsequent
intestinal
barrier
dysfunction,
together
oxidative
stress
increased
inflammatory
responses,
plays
role
pathogenesis
gastrointestinal
diseases.
Moreover,
encourage
inflammation-dysplasia-carcinoma
sequence
various
mechanisms,
stress,
dysregulation
cellular
signalling
cell
cycle
impairment
genomic
instability.
In
this
narrative
review,
we
will
describe
interplay
between
pollutants,
microbiota,
system,
focusing
their
relationship
bowel
diseases
colorectal
cancer.
Understanding
biological
mechanisms
underlying
health-to-disease
transition
may
allow
design
public
health
policies
aimed
at
reducing
burden
disease
pollutants.
PeerJ,
Год журнала:
2025,
Номер
13, С. e19047 - e19047
Опубликована: Фев. 26, 2025
Background
Exposure
to
fine
particulate
matter
(PM2.5)
is
known
increase
oxidative
stress,
impacting
health
adversely.
This
study
examines
the
relationship
between
PM2.5
exposure
and
stress
biomarkers
in
Chiang
Mai,
Thailand.
Methods
A
pilot
prospective
observational
was
conducted
Samoeng
District,
including
25
healthy
participants
(age
25–60
years).
Urine
samples
were
collected
during
high
(March–April
2023)
low
(May–July
seasons.
concentrations
monitored
daily
from
Northern
Thailand
Air
Quality
Health
Index
(NTAQHI)
system.
Biomarkers
analyzed
included
1-hydroxypyrene
(1-OHP)
using
high-performance
liquid
chromatography
(HPLC),
malondialdehyde
(MDA)
via
Spectrophotometry,
8-epi-prostaglandin
F2
α
(8-epi-PGF2
)
with
Enzyme-linked
Immunosorbent
Assay
(ELISA).
Statistical
analysis
performed
IBM
SPSS
Statistics
22.0.
Results
Significant
increases
urinary
1-OHP,
MDA,
8-epi-PGF2
observed
season
compared
season.
The
mean
concentration
of
67
µg/m
3
pollution
7
pollution.
Elevated
levels
these
indicate
increased
associated
higher
exposure.
Conclusions
highlights
a
significant
association
elevated
findings
suggest
that
contributes
potentially
leading
adverse
outcomes.
Environment & Health,
Год журнала:
2024,
Номер
2(9), С. 672 - 680
Опубликована: Июль 30, 2024
Restricted
fetal
growth
(RFG)
is
a
leading
contributor
to
perinatal
mortality
and
has
been
associated
with
gestational
exposure
air
pollution,
such
as
fine
particulate
matter
(PM
