Bulletin of the National Research Centre/Bulletin of the National Research Center,
Год журнала:
2024,
Номер
48(1)
Опубликована: Май 29, 2024
Abstract
Background
The
gonadotropins
lutropin
and
follitropin
stimulate
steroid
synthesis
in
the
gonads
during
gonadal
maturation
by
promoting
oogenesis
spermatogenesis.
Endocrine
disruptors
such
as
lindane
(γHCH)
can
alter
reproductive
stage
so
could
puberty
interfering
with
signaling.
γHCH
was
classified
World
Health
Organization
“moderately
restricted”,
2009
it
is
production
agricultural
use
prohibited,
under
Stockholm
Convention,
however,
its
a
pharmaceutical
treatment
against
lice
scabies
still
allowed
(and
mainly,
for
health
sector).
This
study
aimed
to
examine
effects
of
single-dose
exposure
young
mice
(
Mus
musculus
)
on
concentration,
correlate
maturity
status
phenotypic
characteristics.
Methods
Young
γHCH-treated
(16
females
16
males)
received
single
dose
25,
10,
5,
or
0
µg/ml
per
gram
body
weight,
ocular
route.
Once
secondary
sexual
characteristics
were
observed,
dissected
examined
using
histological
techniques
ovarian
follicles
dependent
independent
gonadotropins;
testicles
inactive,
early
late
spermatogenesis;
blood
processed
ELISA
kit.
Results
results
indicate
significant
differences
concentration
between
males
(Fisher
p
<
0.05).
levels
showed
tendency
decrease
females,
whereas,
they
tended
increase
increased.
In
observed
that
at
decreased
42.3%
83.7%,
respectively
25
µg/ml;
while
males,
increased
51.9%
µg/ml,
10
242.5%.
Contrary
that,
increasing
dose,
disagreeing
idea
coincide
onset
maturity.
Conclusions
allow
us
infer
promote
non-monotonic
responses;
this
does
not
seem
doses
conditions
present
experiment.
Environmental Science & Technology,
Год журнала:
2024,
Номер
58(28), С. 12542 - 12553
Опубликована: Июль 5, 2024
Although
exogenous
chemicals
frequently
exhibit
a
biphasic
response
in
regulating
plant
growth,
characterized
by
low-dose
stimulation
and
high-dose
inhibition,
the
underlying
mechanisms
remain
elusive.
This
study
demonstrates,
for
first
time,
compensatory
function
of
rhizosphere
microbiota
assisting
plants
to
withstand
pesticide
stress.
It
was
observed
that
pak
choi
plants,
foliar-spraying
imidacloprid
at
both
low
high
doses,
could
increase
total
number
bacteria
enrich
numerous
beneficial
bacteria.
These
have
capabilities
promoting
growth
degrading
pesticide,
such
as
Nocardioides,
Brevundimonas,
Sphingomonas.
The
bacterial
communities
were
recruited
stressed
through
increasing
release
primary
metabolites
root
exudates,
amino
acids,
fatty
lysophosphatidylcholines.
At
doses
application,
microbial
effect
overcame
stress,
leading
promotion.
However,
with
insufficient
counteract
resulting
inhibition.
findings
pave
way
designing
improved
application
strategies
contribute
better
understanding
how
can
be
used
an
eco-friendly
approach
mitigate
chemical-induced
stress
crops.
Toxics,
Год журнала:
2024,
Номер
12(8), С. 555 - 555
Опубликована: Июль 30, 2024
Increasing
evidence
has
suggested
that
nanoplastic
pollution
become
a
global
concern.
More
importantly,
transgenerational
toxicity
can
be
induced
by
nanoplastics
at
predicted
environmentally
relevant
doses
(ERDs).
Considering
amino
modification
could
increase
toxicity,
we
compared
neurotoxicity
between
pristine
polystyrene
nanoparticle
(PS-NP)
and
amino-modified
PS-NP
(NH
Environmental Science & Technology,
Год журнала:
2024,
Номер
58(21), С. 9314 - 9327
Опубликована: Май 6, 2024
Globally
implemented
ecological
risk
assessment
(ERA)
guidelines
marginalize
hormesis,
a
biphasic
dose–response
relationship
characterized
by
low-dose
stimulation
and
high-dose
inhibition.
The
present
study
illuminated
the
promise
of
hormesis
as
scientific
model
for
ERA
per-
polyfluoroalkyl
substances
(PFAS)
represented
perfluorooctanoic
acid
(PFOA)
perfluorooctanesulfonic
(PFOS).
A
total
266
hormetic
relationships
were
recompiled
from
1237
observations,
covering
30
species
nine
representative
taxonomic
groups.
standardized
amplitudes
followed
log-normal
probability
distribution,
being
subject
to
limits
biological
plasticity
but
independent
stress
inducers.
SHapley
Additive
exPlanations
algorithm
revealed
that
target
endpoint
was
most
important
variable
explaining
amplitudes.
Subsequently,
quantitative
frameworks
established
incorporate
into
predicted
no-effect
concentration
levels,
with
lower
induction
dose
zero-equivalent
point
broader
zone
PFOS.
Realistically,
10,117
observed
concentrations
PFOA
PFOS
gathered
worldwide,
4%
which
fell
within
zones,
highlighting
environmental
relevance
hormesis.
Additionally,
potential
identified
in
other
legacy
emerging
PFAS
well
their
alternatives
mixtures.
Collectively,
it
is
time
concept
studies
facilitate
more
realistic
characterizations.
The Science of The Total Environment,
Год журнала:
2023,
Номер
910, С. 168669 - 168669
Опубликована: Ноя. 19, 2023
Titanium
dioxide
nanoparticles
have
attracted
considerable
attention
due
to
their
extensive
applications;
however,
multifaceted
influence
on
plant
physiology
and
the
broader
environment
remains
a
complex
subject.
This
review
systematically
synthesizes
recent
studies
hormetic
effects
of
TiO2
plants
-
phenomenon
characterized
by
dual
dose-response
behavior
that
impacts
various
functions.
It
provides
crucial
insights
into
molecular
mechanisms
underlying
these
effects,
encompassing
photosynthesis,
oxidative
stress
response
gene
regulation.
The
significance
this
article
consists
in
its
emphasis
necessity
establish
clear
regulatory
frameworks
promote
international
collaboration
standardize
responsible
adoption
nano-TiO2
technology
within
agricultural
sector.
findings
are
presented
with
intention
stimulating
interdisciplinary
research
serving
as
an
inspiration
for
further
exploration
investigation
vital
continually
evolving
field.
Journal of Agricultural and Food Chemistry,
Год журнала:
2025,
Номер
unknown
Опубликована: Май 13, 2025
The
placenta
is
a
vital
organ
that
facilitates
maternal-fetal
circulation,
ensuring
proper
fetal
development.
Phenanthrene
(Phe),
typical
low-molecular-weight
polycyclic
aromatic
hydrocarbon,
widely
present
in
the
environment
and
food.
In
this
study,
pregnant
mice
were
exposed
to
Phe
(0,
0.6,
6,
60
μg/kg
of
body
weight)
via
gavage
every
3
days
from
pregnancy
day
0.5
(PGD
0.5)
for
total
six
exposures
during
pregnancy.
Placentas
collected
on
PGD
18.5
analysis.
results
showed
exposure
altered
placental
structure
function,
inducing
trophoblast
thickening
at
low
doses
(0.6
μg/kg)
but
thinning
higher
(6
μg/kg),
reducing
blood
cell
density
labyrinth,
disrupting
metabolite
composition,
causing
oxidative
damage,
leading
excessive
fibrosis
calcification.
Molecular
analysis
revealed
PCNA
was
significantly
upregulated
0.6
group
downregulated
6
groups,
indicating
an
initial
compensatory
proliferative
response
impaired
proliferation
doses,
while
Bad
abnormally
accumulated
trophoblasts
dose-dependently
upregulated,
along
with
decline
antioxidant
capacity.
Meanwhile,
increases
protein
levels
TGF-β1,
Smad2,
p-Smad2,
Smad1/5/9,
p-Smad1/5/9,
BMP2,
TIMP1,
Runx2,
Collagen
I,
SMA,
decrease
MMP1
level
observed.
These
findings
suggested
induced
activation
TGF-β/Smad2
pathway
BMP2/Smad1/5/9/Runx2
pathway,
which
might
further
lead
increased
calcification,
together
elevated
cellular
apoptosis,
destroyed
placenta,
reduced
counts,
impairing
exchange
efficiency
systemic
metabolic
imbalances,
impair
health
their
offspring.
