Trends in Plant Science, Год журнала: 2024, Номер unknown
Опубликована: Дек. 1, 2024
Язык: Английский
Animals, Год журнала: 2025, Номер 15(4), С. 610 - 610
Опубликована: Фев. 19, 2025
Perfluorooctane sulfonate (PFOS) contamination poses a significant environmental threat due to its widespread distribution and persistence. However, the hepatotoxic effects of PFOS on key aquatic species, such as crucian carp, remain understudied. This study systematically investigated hepatotoxicity underlying molecular mechanisms associated with exposure in carp over 21 day period. We determined 96 h 50% lethal concentration (LC50) 23.17 mg/L. Histopathological transcriptomic analyses confirmed PFOS-induced liver damage characterized by venous congestion, nucleolar dissolution cellular vacuolation. Transcriptomic profiling further identified 1036 differentially expressed genes (DEGs), involving critical pathways related lipid energy metabolism, immunity, endocrine regulation. These are integral development nonalcoholic fatty disease (NAFLD). Specifically, DEGs metabolism showed changes, while those involved indicated disrupted ATP production mitochondrial function. Genes immune response revealed an upregulation pro-inflammatory markers, hormone regulation highlighted alterations signaling. Our findings emphasized that exhibits acute toxicity potentially inducing disrupting multiple physiological systems. research provides theoretical foundation for mitigating pollution protecting eco-health, contributing broader ecological conservation biology discussions.
Язык: Английский
Процитировано
0
Journal of Hazardous Materials, Год журнала: 2024, Номер 480, С. 136115 - 136115
Опубликована: Окт. 9, 2024
Язык: Английский
Процитировано
3
Journal of Hazardous Materials, Год журнала: 2024, Номер 480, С. 136205 - 136205
Опубликована: Окт. 18, 2024
Язык: Английский
Процитировано
1
Trends in Plant Science, Год журнала: 2024, Номер unknown
Опубликована: Дек. 1, 2024
Язык: Английский
Процитировано
0