Cited by Fate and impact at molecular level of diatrizoic acid and iohexol contrast agents in Dreissena polymorpha mollusks

Molecular basis for the effects of SSRIs in non-target aquatic invertebrates: a case study with Mytilus galloprovincialis early larvae DOI

Beatrice Risso, Angelica Miglioli, Teresa Balbi

et al.

Aquatic Toxicology, Journal Year: 2025, Volume and Issue: 282, P. 107306 - 107306

Published: March 1, 2025

Language: Английский

Citations

Hemolymph responses of the Thai freshwater mussel Hyriopsis bialata exposed to atrazine DOI

Sarocha Soimalaitong,

Pattanan Nuchan,

Akkarasiri Sangsawang

et al.

Journal of Hazardous Materials, Journal Year: 2025, Volume and Issue: 492, P. 138064 - 138064

Published: March 29, 2025

Language: Английский

Citations

Exposure to environmental pharmaceuticals affects the macromolecular composition of mussels digestive glands DOI

Marica Mezzelani, Valentina Notarstefano,

Michela Panni

et al.

Scientific Reports, Journal Year: 2024, Volume and Issue: 14(1)

Published: April 23, 2024

Abstract Human pharmaceuticals represent a major challenge in natural environment. A better knowledge on their mechanisms of action and adverse effects cellular pathways is fundamental to predict long-term consequences for marine wildlife. The FTIRI Imaging (FTIRI) spectroscopy represents vibrational technique allowing map specific areas non-homogeneous biological samples, providing unique biochemical ultrastructural fingerprint the tissue. In this study, has been applied, first time, characterize (i) chemical building blocks digestive glands Mytilus galloprovincialis , (ii) alterations (iii) resilience macromolecular composition, after 14-days exposure 0.5 µg/L carbamazepine (CBZ), valsartan (VAL) mixture, followed by recovery period. Spectral features mussels provided insights composition topographical distribution main groups macromolecules, such as proteins, lipids, glycosylated compounds. Pharmaceuticals caused an increase total amount protein significant decrease lipids levels. Changes reflected modulation molecular thus supporting our emerging pollutants. Overall, applied approach could added value within integrated strategies effects-based evaluation environmental contaminants.

Language: Английский

Citations

Drug–Drug Interactions of Selective Serotonin Reuptake Inhibitors: A Pharmacovigilance Study on Real-World Evidence from the EudraVigilance Database DOI

Carmen Maximiliana Dobrea, Adina Frum, Anca Butucă

et al.

Pharmaceuticals, Journal Year: 2024, Volume and Issue: 17(10), P. 1278 - 1278

Published: Sept. 26, 2024

As the most common psychiatric symptom, depression represents a subject of high interest for medical community.

Language: Английский

Citations

Differential bioconcentration and sensitivity of Dreissena polymorpha and Dreissena rostriformis bugensis to the antidepressant sertraline DOI

Céline Passignat,

Justine Flayac,

Romane Lerebourg

et al.

Journal of Hazardous Materials, Journal Year: 2024, Volume and Issue: 482, P. 136628 - 136628

Published: Nov. 22, 2024

Language: Английский

Citations

Low expression of lysosome-related genes KCNE1, NPC2, and SFTPD promote cancer cell proliferation and tumor associated M2 macrophage polarization in lung adenocarcinoma DOI

Ziming Wang,

Zhilin Ning,

Chao Ma

et al.

Heliyon, Journal Year: 2024, Volume and Issue: 10(6), P. e27575 - e27575

Published: March 1, 2024

BackgroundRecent research has shown that lysosomes play a critical role in the onset and progression of malignancy by regulating tumor cell death through several mechanisms. Nevertheless, involvement lysosome-associated genes (LSAGs) lung adenocarcinoma (LUAD) is still not well understood.MethodsLSAGs were identified malignant epithelial cells, as biologically functionally annotated comprehensive integration single-cell bulk RNA-sequencing data. Prognostic characterization LSAGs was established, which accuracy reliability assessed one-way Cox LASSO regression. Correlations between LSAG properties immune infiltration, chemotherapy, immunotherapy analyzed integrated omics Finally, we characterized expression three (KCNE1, NPC2, SFTPD) epithelium their impact on related phenotypes.ResultsWe 18 associated with prognosis, 3 used to construct prognostic models. High-risk patients had worse survival model predicted it better than other clinical indicators. Based functional enrichment analyses, binding molecular activity functions, inhibition DNA damage repair growth, IL7 signaling pathway, glycolysis. M0 macrophages M1 substantially enriched high-risk patients. Conversely, there considerable resting dendritic cells M2 at low risk. We also found risk scores outcome immunotherapy. In vitro, KCNE1, SFTPD lowly expressed higher percentage macrophage infiltration. Overexpression suppressed proliferation invasion remarkably reduced polarization cellular secretion pro-tumor cytokines.ConclusionsWe LASGs—KCNE1, SFTPD—to develop validate predictive signature for LUAD Furthermore, promotes cancer polarization. Our study may provide fresh perspectives customized

Language: Английский

Citations

Effects of Water Temperature Increase on Transcriptomic, Biochemical, and Histopathological Responses of the Bivalve Species Mytilus Galloprovincialis to the Antineoplastic Drug 5-Fluorouracil DOI

Vanessa Queirós, Carla Leite, Ulisses M. Azeiteiro

et al.

Published: Jan. 1, 2024

Language: Английский

Citations

Antidepressants as new endocrine disruptors? – transcriptomic profiling in gonads of Mytilus trossulus exposed to norfluoxetine DOI

Paulina Goździk, Katarzyna Smolarz,

Anna Hallmann

et al.

Marine Pollution Bulletin, Journal Year: 2024, Volume and Issue: 208, P. 117015 - 117015

Published: Sept. 20, 2024

Language: Английский

Citations

Fate and impact at molecular level of diatrizoic acid and iohexol contrast agents in Dreissena polymorpha mollusks DOI

Carine Arnaudguilhem, Gaëlle Danièle, Christelle Bonnefoy

et al.

Environmental Science and Pollution Research, Journal Year: 2024, Volume and Issue: 31(49), P. 59507 - 59520

Published: Oct. 2, 2024

Language: Английский

Citations