Xenobiotic metabolism activity of gut microbiota from six marine species: combined taxonomic, metagenomic, and in vitro transformation analysis

Journal of Hazardous Materials, Год журнала: 2024, Номер 480, С. 136152 - 136152

Опубликована: Окт. 12, 2024

Язык: Английский

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Maternal probiotic supplementation protects against PBDE-induced developmental, behavior and metabolic reprogramming in a sexually dimorphic manner: Role of gut microbiome

Archives of Toxicology, Год журнала: 2024, Номер unknown

Опубликована: Ноя. 9, 2024

Polybrominated diphenyl ethers (PBDEs) are endocrine-disrupting persistent organic pollutants (POPs) used as flame retardants in a wide range of commercial applications. We have previously reported neurobehavioral and metabolic reprogramming produced by developmental PBDEs. PBDEs perturb the microbiome, an influencer life-long health, while probiotic supplementation with Limosilactobacillus reuteri (LR) can avert endocrine disruption. We, therefore, tested hypothesis that perinatal maternal LR would protect gut microbiome richness diversity, milestones, adult neurobehavior homeostasis PBDE-exposed offspring. C57BL/6N dams were orally exposed to penta-mixture PBDEs, DE-71, at 0.1 mg/kg/day, or corn oil vehicle (VEH/CON) during gestation lactation. Mice offspring received DE-71 VEH/CON without co-administration (ATCC-PTA-6475) indirectly via their mother from gestational day (GD) 0 until postnatal (P)21 (Cohort 1), continued receive directly P22 through adulthood 2). Results fecal 16S rRNA sequencing indicated age- sex-dependent effects on microbial communities. Maternal treatment protected against DE-71-induced reduction α-diversity females β-diversity alterations P30 males. In females, changed relative abundance specific bacterial taxa, such Tenericutes Cyanobacteria (elevated) Deferribacterota (reduced). males, several Firmicutes taxa elevated, Proteobacteria, Chlamydiae, Bacteroidota reduced. The number disrupted normalized was follows: 100% 33% males 25% P30. delay body weight gain ameliorated abnormal timing incisor eruption both sexes. Further, exaggerated digging sexes well locomotor hyperactivity mitigated only females. Other benefits therapy included normalization glucose tolerance, insulin-to-glucose ratio plasma leptin This study provides evidence mitigate POP-induced neurodevelopment, neurobehavior, metabolism association modified community structure manner.

Язык: Английский

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The Effect of Moderate Temperature Rise on Emitted Chemicals from Modern Building Materials

Buildings, Год журнала: 2024, Номер 14(11), С. 3683 - 3683

Опубликована: Ноя. 19, 2024

Chemical emissions from building materials may significantly impact indoor air quality and potentially human health, since individuals spend most of their time indoors. With rising global temperatures more frequent heatwaves, materials’ resilience becomes crucial for structural integrity. However, the effects temperature rise on material are not systematically studied. This study investigates effect a moderate volatile organic compound (VOC) aldehyde eighteen commonly used materials, such as engineered hardwood, nylon carpet, terrazzo flooring, acoustic tile, at two elevated yet realistic points. The chemical were collected using micro-chamber setup analyzed thermal desorption/gas chromatography/mass spectrometry high-performance liquid chromatography. results showed that 78% tested demonstrated increased higher temperatures. Wood-flooring statistically significant increases in formaldehyde temperatures, which could be associated with health risks. Eight particularly those large surface area applications, half these labeled “low-VOC”. These findings inform updating standards third-party certification respect to variation when assessing emissions. research aims provide comprehensive understanding VOC emerging environmental conditions due extreme heat climate scenarios.

Язык: Английский

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Phthalates esters disrupt demersal fish behavior: Unveiling the brain-gut axis impact

Ecotoxicology and Environmental Safety, Год журнала: 2024, Номер 289, С. 117470 - 117470

Опубликована: Дек. 7, 2024

Язык: Английский

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