Uptake, translocation, and metabolism of organophosphate esters (OPEs) in plants and health perspective for human: A review

Environmental Research, Год журнала: 2024, Номер 249, С. 118431 - 118431

Опубликована: Фев. 10, 2024

Язык: Английский

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Detection and screening of organophosphate esters in infant formula from Shanghai, China: distribution characteristics and risk evaluation

Food Additives & Contaminants Part A, Год журнала: 2025, Номер unknown, С. 1 - 14

Опубликована: Фев. 6, 2025

Organophosphate esters (OPEs) have raised great concerns in recent years. However, information regarding their occurrence infant formula remains limited. Thus, thirty-two OPEs were measured sold Shanghai, China 2023. The results showed that OPE was widespread. median concentrations of organophosphate diesters, triesters, and total 2.28, 5.20, 8.63 ng/g, respectively. Tris(2-chloroisopropyl) phosphate (TCPP) the highest concentration (1.95 ng/g), followed by triethyl phosphate, bis(1-chloro-2-propyl) (BCPP), tri-isobutyl triphenyl (0.532-0.581 ng/g). dominant chloro-OPEs (TCPP BCPP) regional-specific. Compared to corresponding diester often lower, except for bis(2-butoxyethyl) tributoxyethyl phosphate. Additionally, five novel with phenyl groups identified, showing high detection frequencies comparable TCPP. Raw materials food processing methods might affect individual OPEs. estimated daily intakes (EDIs) ranged from 62.3 355 ng/kg bw/day. EDI occurred infants 0-6 months age but posed no obvious health risk toddlers. Further studies are still needed evaluate possible implications arising metabolites, as well potentially synergistic effects.

Язык: Английский

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Occurrence of Organophosphate Esters in Food and Food Contact Materials and Related Human Exposure Risks

Journal of Agricultural and Food Chemistry, Год журнала: 2025, Номер unknown

Опубликована: Фев. 12, 2025

Organophosphate esters (OPEs) are a class of anthropogenic chemicals that have long been used as plasticizers and flame retardants. Dietary intake is an important OPE exposure pathway for humans. Since OPEs usually industrial additives in food contact materials (FCMs), can enter foods through to FCMs. This paper focused on FCM-related risks foods, summarizing the presence FCMs analyzing migration from food, assessing dietary risk Overall, levels were at higher than those foods. Processed packaged contained nonprocessed/fresh The investigations revealed be more likely transferred under conditions temperature longer time. We hope this work will extend our current knowledge apportionment sources highlight existing research gaps.

Язык: Английский

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Nationwide investigation on organophosphate esters and di-esters in raw grains from China: Distribution, sources, and implications for risk assessment

Environment International, Год журнала: 2025, Номер unknown, С. 109437 - 109437

Опубликована: Апрель 1, 2025

Studies on dietary exposure to organophosphate esters (OPEs) and diesters (di-OPEs) are limited, especially regarding di-OPEs their presence in raw grains, which fundamental staples of the human diet. In this study, 18 OPEs 8 were measured 289 grain samples from 13 major grain-producing regions China belonging four types: wheat, rice, maize, soybean. Tris(2-chloroisopropyl) phosphate (TCIPP) tris(2-ethylhexyl) (TEHP) dominant OPEs, while bis(2-ethylhexyl) (BEHP) was main di-OPE. The highest concentrations both ∑OPEs ∑di-OPEs observed soybean (median: 14.9 1.87 ng/g, respectively), followed by wheat (4.79 1.69 ng/g), maize (2.63 1.10 rice (2.37 0.726 ng/g). regional distribution relatively homogeneous. significantly higher Sichuan Shandong provinces, whereas spatial patterns differed, suggesting separate sources for di-OPEs. Soil type, straw turnover, pesticide use could affect TEHP, tri(2-chloroethyl) (TCEP), triethyl (TEP) respectively. Except TEHP tris(1,3-dichloro-2-propyl) (TDCPP), whose similar polished other accounted only 1.9-36 % those reported previously, indicating industrial processing as source these marketed grains. estimated daily intake through consumption 25.0-40.4 ng/kg bw/d 7.55-11.7 bw/d, respectively, primarily contributed than dust ingestion drinking water, that is exposure. Di-OPEs directly ingested grains derived metabolism parent implying estimating OPE based internal di-OPE levels inaccurate warrants further research.

Язык: Английский

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Plastic additives in the diet: occurrence and dietary exposure in different population groups

Journal of Hazardous Materials, Год журнала: 2025, Номер 493, С. 138317 - 138317

Опубликована: Апрель 17, 2025

Язык: Английский

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Cardiotoxicity of tris(2-chloroethyl) phosphate exposure: Insights into the role of oxygen sensor mediated energy metabolism remodeling

Journal of Hazardous Materials, Год журнала: 2025, Номер 486, С. 137113 - 137113

Опубликована: Янв. 5, 2025

Язык: Английский

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Bioaccumulation patterns, trophic transfer characteristics and dietary exposure potential of tetrabromobisphenol A analogs in a coral reef food web of the Xisha Islands, South China Sea

Journal of Environmental Exposure Assessment, Год журнала: 2025, Номер 4(1)

Опубликована: Март 6, 2025

As a typical class of novel organic pollutants, tetrabromobisphenol A (TBBPA) analogs have been widely detected in various environmental matrices. Several toxicological studies highlighted that the accumulation pollutants is basis for assessing their ecological effects and potential risks. However, bioaccumulation trophic transfer TBBPA marine food webs are not fully understood. This study selected most important coral reef islands South China Sea as area to investigate patterns characteristics within tropical web. TBBPA, S (TBBPS), bis(2-hydroxyethyl ether) (TBBPA-BHEE), bis(glycidyl (TBBPA-BGE) prevalent water, sediment, organisms around Xisha Islands. The concentrations these compounds varied significantly among species (P < 0.05), with notably higher ∑TBBPA observed invertebrates than fish. Moreover, Log BAFs TBBPS, TBBPA-BHEE were all lower 3.30, whereas TBBPA-BGE exhibited high some species. TBBPA-BHEE, negatively correlated level indicating pronounced dilution throughout In addition, hydrophobicity metabolism found be factors affecting analogs. results revealed dietary exposure seafood poses no significant health risks local population.

Язык: Английский

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Exposure levels and maternal transfer of emerging organophosphate flame retardants (OPFRs) in pregnant women: Comparison with traditional OPFRs

Environment International, Год журнала: 2024, Номер 191, С. 108996 - 108996

Опубликована: Сен. 1, 2024

Prenatal exposure to organophosphorus flame retardants (OPFRs) has been linked with adverse effects on reproductive health, and new OPFRs are continually emerging. In this study, emerging OPFRs, such as bis(2-ethylhexyl) phenyl phosphate (BEHPP), triamyl (TAP), tris(4-tert-butylphenyl) (T4tBPPP), oxydi-2,1-ethanediyl phosphoric acid tetrakis(2 chloro-1-methylethyl) ester (RDT905), cresyl diphenyl (CDP), 2-isopropylphenyl (2IPPDPP), were detected in 84 %, 100 52 40 % of 25 decidua samples average concentrations 2.36, 6.21, 1.5, 2.6, 1.07, 0.09 ng/g dry weight (dw), respectively. Six the aforementioned (BEHPP, T4tBPPP, RDT905, 2IPPDPP, CDP, TAP) simultaneously paired chorionic villus samples, their 11.3, 1.77, 3.64, 0.11, 0.58, 3.34 ng/g, which significantly higher than positively correlated those samples. The geometric mean concentration ratios between for BEHPP, TAP 4.02, 1.61, 1.73, 1.48, 0.82, 0.69, respectively, consistent transthyretin binding-dependent behavior. especially BEHPP relatively high maternal transfer, is concern from view women's health.

Язык: Английский

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Simultaneous analysis of several plasticizer classes in different matrices by on-line turbulent flow chromatography-LC–MS/MS

Analytical and Bioanalytical Chemistry, Год журнала: 2024, Номер 416(29), С. 6957 - 6972

Опубликована: Окт. 19, 2024

Abstract The development of methodologies for the determination plasticizers is essential assessing environmental and human impact resulting from use plastics. A fast analytical method with on-line purification based on turbulent flow chromatography (TFC) coupled to tandem mass spectrometry (MS–MS) has been developed analysis ten phthalates, four alternative (including adipates citrates), 20 organophosphate esters (OPEs). validated across different matrices. Analytical parameters showed acceptable recoveries ranging between 50 125%, RSDs lower than 20%, mLODs 0.001–2.08 ng g −1 wet weight (ww), 0.002–0.30 , 0.001–0.93 m −3 foodstuffs, face masks, ambient air, respectively. These were applied foodstuff samples purchased in grocery stores, reusable self-filtering indoor air measured locations. Plasticizers detected all analyzed samples, values up 22.0 μg ww, 6.78 572 contribution each family total plasticizer content varied 1.3 87%, 0.5 98%, 65% plasticizers, OPEs, findings highlighted need capable simultaneously a wide number minimal extraction steps. This capability crucial order obtain more conclusive insights into these pollutants both environment health, arising sources exposure such as plastic materials, atmospheric air. Graphical

Язык: Английский

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Association between organophosphate esters individual and mixed exposure with the risk of hyperlipidemia and serum lipid levels among adults in Wuhan, China

Environmental Science and Pollution Research, Год журнала: 2024, Номер 31(35), С. 48629 - 48640

Опубликована: Июль 22, 2024

Язык: Английский

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