Medical Research Archives,
Год журнала:
2023,
Номер
11(12)
Опубликована: Янв. 1, 2023
Background:
This
perspective
concerning
hepatoxicity
of
per-
and
polyfluoroalkyl
substances
(PFAS)
aims
to
provide
a
current
understanding
the
damage
reasonable
clinician
responses
needs
concerned
patients
affected
communities.
Methods:
Search
strategy
included
PFAS
following:
human
liver
toxicity/disease;
relevant
biomarkers
including
transaminases,
lipids,
uric
acid;
predictive
equations
(for
disease),
imaging
modalities,
histologic
findings.
Experimental
data
outcomes
disrupted
hepatic
metabolic
pathways
was
also
reviewed.
Recommended
clinical
approaches
communities
sought
in
both
National
Library
Medicine
organizational
websites.
Results:
Several
reliably
cause
adverse
changes
biomarkers,
with
strong
consistency
between
experimental
data.
Adverse
population
include
cholesterol
LDL
cholesterol,
acid.
biomarker
triad
suggests
that
mechanisms
are
or
resemble
associated
steatotic
disease,
which
is
found
across
species
following
exposure.
Human
studies
sparse
mostly
support
inference
toxicant
resembles
pathway
can
lead
from
steatosis
more
serious
stages
disease
due
metabolism
fatty
acids.
Advice
clinicians
reviewed
various
agencies
nonprofits
organizations
committee
US
Academies
Sciences,
Engineering,
Medicine,
nonprofit/university
collaboration
REACH.
Discussion:
Converging
lines
evidence
indict
as
(and
trans-species)
hepatotoxins
continuum
nature
injury.
Increases
abnormal
transaminases
sparser
biopsy
findings
clinically
important
contributing
public
health
problem.
It
still
challenging
decide
many
definitively
is/are
most
Many
use
remain
virtually
unstudied,
research
emergency.
Simple
concerns
heavily
contaminated
communities,
within
capabilities
offices,
Seminars in Liver Disease,
Год журнала:
2025,
Номер
unknown
Опубликована: Март 21, 2025
Environmental
pollutants
significantly
impact
liver
disease
development,
progression,
and
outcomes.
This
review
examines
the
complex
relationship
between
environmental
exposures
pathology,
from
malignant
conditions
like
hepatocellular
carcinoma
to
steatotic
cholestatic
diseases.
Key
factors
include
air
pollutants,
volatile
organic
compounds,
persistent
heavy
metals,
per-
polyfluoroalkyl
substances.
These
compounds
can
act
through
multiple
mechanisms,
including
endocrine
disruption,
metabolic
perturbation,
oxidative
stress,
direct
hepatotoxicity.
The
of
these
is
often
modified
by
such
as
sex,
diet,
genetic
predisposition.
Recent
research
has
revealed
that
even
low-level
certain
chemicals
affect
health,
particularly
when
combined
with
other
risk
factors.
emergence
exposomics
a
tool
promises
enhance
our
understanding
how
influence
disease.
Importantly,
exposure
effects
vary
demographic
socioeconomic
factors,
highlighting
justice
concerns.
Implementation
this
knowledge
in
clinical
practice
requires
new
diagnostic
approaches,
healthcare
system
adaptations,
increased
awareness
among
medical
professionals.
In
conclusion,
provides
comprehensive
examination
current
evidence
linking
discusses
implications
for
public
health
policy.
Environmental Chemistry,
Год журнала:
2025,
Номер
22(2)
Опубликована: Март 24, 2025
Environmental
context
Perfluorinated
compounds
are
emerging
organic
contaminants
recently
detected
in
various
environmental
matrices
and
remain
largely
unregulated.
Among
these
matrices,
air
is
the
least
studied
one
due
to
analytical
challenges.
This
review
explores
trends
analysing
perfluorinated
with
use
of
bioindicators
highlights
future
research
needs
address
existing
gaps
detection
monitoring.
Abstract
(PFCs)
persistent
pollutants
extensive
industrial
applications,
including
firefighting
foams,
nonstick
coatings
textiles.
Their
contamination
widespread
their
resistance
degradation
long-range
atmospheric
transport,
leading
presence
ecosystems.
PFCs
pose
significant
hazards,
bioaccumulation,
endocrine
disruption,
hormonal
imbalances
potential
carcinogenic
effects.
Despite
ubiquity
compartments,
studies
limited
provides
first
comprehensive
analysis
biomonitoring
atmosphere
using
bioindicators.
The
databases
consulted
for
include
Web
Science,
Scopus,
ScienceDirect,
PubMed
Google
Scholar.
By
examining
literature,
we
identify
key
gaps,
highlight
limitations
underscore
need
standardised
methods
improve
monitoring
accuracy.
Environmental Pollution,
Год журнала:
2024,
Номер
358, С. 124468 - 124468
Опубликована: Июнь 29, 2024
Urban
aquifers
are
at
risk
of
contamination
from
persistent
and
mobile
organic
compounds
(PMOCs),
especially
per-
polyfluoroalkyl
substances
(PFAS),
which
artificial
widely
used
across
various
industrial
sectors.
PFAS
considered
toxic,
persistent,
have
therefore
gained
significant
attention
in
environmental
chemistry.
Moreover,
precursors
could
transform
into
more
recalcitrant
products
under
natural
conditions.
However,
there
is
limited
information
about
the
processes
affect
their
behaviour
groundwater
field-scale.
In
this
context,
aim
study
to
assess
presence
an
urban
aquifer
Barcelona,
identify
that
control
evolution
along
flow.
21
6
river
samples
were
collected
revealing
16
3
novel
PFAS.
Short
ultra-short
chain
found
be
ubiquitous,
with
highest
concentrations
detected
for
perfluorobutanesulfonic
acid
(PFBS),
trifluoroacetic
(TFA)
trifluoromethanesulfonic
(TFSA).
Long
present
very
low
(<50
ng/L).
It
was
observed
redox
conditions
influence
a
number
controlling
attenuation
or
behaviour.
Most
showed
accumulation,
possibly
explained
by
sorption/desorption
transformation
processes,
highlighting
challenges
associated
remediation.
addition,
removal
different
intensities
three
revealed.
Our
results
help
establish
principles
flow,
important
development
conceptual
models
plan
adopt
site
specific
management
activities
(e.g.,
Managed
Aquifer
Recharge).
Reproduction Fertility and Development,
Год журнала:
2024,
Номер
36(9)
Опубликована: Май 14, 2024
Poly-
and
perfluoroalkyl
substances
(PFAS)
are
a
prominent
class
of
persistent
synthetic
compound.
The
widespread
use
these
in
various
industrial
applications
has
resulted
their
pervasive
contamination
on
global
scale.
It
is
therefore
concerning
that
PFAS
have
propensity
to
accumulate
bodily
tissues
whereupon
they
been
linked
with
range
adverse
health
outcomes.
Despite
this,
the
true
extent
risk
posed
by
humans,
domestic
animals,
wildlife
remains
unclear.
Addressing
questions
requires
multidisciplinary
approach,
combining
fields
chemistry,
biology,
policy
enable
meaningful
investigation
develop
innovative
remediation
strategies.
This
article
combines
perspectives
chemists,
soil
scientists,
reproductive
biologists,
researchers,
contextualise
issue
its
specific
impact
health.
purpose
this
describe
challenges
associated
remediating
PFAS-contaminated
soils
waters
explore
consequences
reproduction.
Furthermore,
current
actions
promote
planetary
protect
ecosystems
presented
instigate
positive
social
change
among
scientific
community.
The Science of The Total Environment,
Год журнала:
2024,
Номер
954, С. 176540 - 176540
Опубликована: Сен. 25, 2024
The
fate
of
per-
and
polyfluoroalkyl
substances
(PFAS)
was
evaluated
at
a
site
where
municipal
biosolids
have
been
applied
annually
for
38
years
as
waste
management
strategy.
Soil
cores
(1.8
m
in
30-cm
sections),
groundwater
from
four
wells,
2022
were
analyzed
PFAS
(54
targeted,
17
semi-quantified)
using
liquid
chromatography
high
resolution
mass
spectrometry
including
suspect
screening.
Total
concentrations
decreased
with
soil
depth
1700
ng/g
to
2.06
ng/g.
distribution
60
mol%
perfluoroalkyl
acid
(PFAA)
precursors
intermediates.
surface
dominated
by
long-chain
PFAAs
(67-76
mol%)
reflecting
precursor
degradation
after
application.
Presence
semi-quantified
intermediates
further
reflects
soil.
Long-chain
diminished
while
short-chain
increased
up
98
96
the
bottom
groundwater,
respectively.
is
consistent
chain-length
dependent
sorption-impacted
transport
organic
carbon
content
(15.2
%
OC)
which
subsequently
(~2-3
OC
>60
cm).
High
upper
horizon
likely
decades
application
rates,
contributed
minimizing
leaching
PFAS.
While
well
within
dedicated
land
disposal
not
drinking
water,
comparison
only,
this
only
marginally
exceeded
EU
water
directive
total
few
individual
PFAS,
but
did
exceed
tenfold,
USEPA
standard
PFOA.
