Invited Perspective. Per- and Polyfluoroalkyl Substances, Hepatotoxicity, and Liver Disease: Evidence and Clinical Responses DOI Open Access
Alan Ducatman, Lida Chatzi

Medical Research Archives, Journal Year: 2023, Volume and Issue: 11(12)

Published: Jan. 1, 2023

Background: This perspective concerning hepatoxicity of per- and polyfluoroalkyl substances (PFAS) aims to provide a current understanding the damage reasonable clinician responses needs concerned patients affected communities. Methods: Search strategy included PFAS following: human liver toxicity/disease; relevant biomarkers including transaminases, lipids, uric acid; predictive equations (for disease), imaging modalities, histologic findings. Experimental data outcomes disrupted hepatic metabolic pathways was also reviewed. Recommended clinical approaches communities sought in both National Library Medicine organizational websites. Results: Several reliably cause adverse changes biomarkers, with strong consistency between experimental data. Adverse population include cholesterol LDL cholesterol, acid. biomarker triad suggests that mechanisms are or resemble associated steatotic disease, which is found across species following exposure. Human studies sparse mostly support inference toxicant resembles pathway can lead from steatosis more serious stages disease due metabolism fatty acids. Advice clinicians reviewed various agencies nonprofits organizations committee US Academies Sciences, Engineering, Medicine, nonprofit/university collaboration REACH. Discussion: Converging lines evidence indict as (and trans-species) hepatotoxins continuum nature injury. Increases abnormal transaminases sparser biopsy findings clinically important contributing public health problem. It still challenging decide many definitively is/are most Many use remain virtually unstudied, research emergency. Simple concerns heavily contaminated communities, within capabilities offices,

Language: Английский

Preparation strategies of waste-derived MOF and their applications in water remediation: A systematic review DOI

Jia-Hang Wang,

Fanying Kong,

Bing-Feng Liu

et al.

Coordination Chemistry Reviews, Journal Year: 2025, Volume and Issue: 533, P. 216534 - 216534

Published: Feb. 24, 2025

Language: Английский

Citations

6
Trophic transfer of sulfonamide antibiotics in aquatic food chains:a comprehensive review with a focus on environmental health risks DOI

Tianwei Peng,

Biao Song,

Yuchen Wang

et al.

Environmental Pollution, Journal Year: 2025, Volume and Issue: unknown, P. 125823 - 125823

Published: Feb. 1, 2025

Language: Английский

Citations

1
Environmental Pollutants, Occupational Exposures, and Liver Disease DOI
Juliane I. Beier,

Jianzhu Luo,

Charis-Marie Vanderpuye

et al.

Seminars in Liver Disease, Journal Year: 2025, Volume and Issue: unknown

Published: March 21, 2025

Environmental pollutants significantly impact liver disease development, progression, and outcomes. This review examines the complex relationship between environmental exposures pathology, from malignant conditions like hepatocellular carcinoma to steatotic cholestatic diseases. Key factors include air pollutants, volatile organic compounds, persistent heavy metals, per- polyfluoroalkyl substances. These compounds can act through multiple mechanisms, including endocrine disruption, metabolic perturbation, oxidative stress, direct hepatotoxicity. The of these is often modified by such as sex, diet, genetic predisposition. Recent research has revealed that even low-level certain chemicals affect health, particularly when combined with other risk factors. emergence exposomics a tool promises enhance our understanding how influence disease. Importantly, exposure effects vary demographic socioeconomic factors, highlighting justice concerns. Implementation this knowledge in clinical practice requires new diagnostic approaches, healthcare system adaptations, increased awareness among medical professionals. In conclusion, provides comprehensive examination current evidence linking discusses implications for public health policy.

Language: Английский

Citations

0
Bioindicators for monitoring atmospheric perfluorinated compounds: review of occurrences, transport, fate and analytical protocols DOI Creative Commons
Nnanake‐Abasi O. Offiong, Imeh J. Okop, Solomon E. Shaibu

et al.

Environmental Chemistry, Journal Year: 2025, Volume and Issue: 22(2)

Published: March 24, 2025

Environmental context Perfluorinated compounds are emerging organic contaminants recently detected in various environmental matrices and remain largely unregulated. Among these matrices, air is the least studied one due to analytical challenges. This review explores trends analysing perfluorinated with use of bioindicators highlights future research needs address existing gaps detection monitoring. Abstract (PFCs) persistent pollutants extensive industrial applications, including firefighting foams, nonstick coatings textiles. Their contamination widespread their resistance degradation long-range atmospheric transport, leading presence ecosystems. PFCs pose significant hazards, bioaccumulation, endocrine disruption, hormonal imbalances potential carcinogenic effects. Despite ubiquity compartments, studies limited provides first comprehensive analysis biomonitoring atmosphere using bioindicators. The databases consulted for include Web Science, Scopus, ScienceDirect, PubMed Google Scholar. By examining literature, we identify key gaps, highlight limitations underscore need standardised methods improve monitoring accuracy.

Language: Английский

Citations

0
Occurrence and fate of perfluoroalkyl and polyfluoroalkyl substances (PFAS) in an urban aquifer located at the Besòs River Delta (Spain) DOI Creative Commons
Carmen Sáez,

Arianna Bautista,

Olha Nikolenko

et al.

Environmental Pollution, Journal Year: 2024, Volume and Issue: 358, P. 124468 - 124468

Published: June 29, 2024

Urban aquifers are at risk of contamination from persistent and mobile organic compounds (PMOCs), especially per- polyfluoroalkyl substances (PFAS), which artificial widely used across various industrial sectors. PFAS considered toxic, persistent, have therefore gained significant attention in environmental chemistry. Moreover, precursors could transform into more recalcitrant products under natural conditions. However, there is limited information about the processes affect their behaviour groundwater field-scale. In this context, aim study to assess presence an urban aquifer Barcelona, identify that control evolution along flow. 21 6 river samples were collected revealing 16 3 novel PFAS. Short ultra-short chain found be ubiquitous, with highest concentrations detected for perfluorobutanesulfonic acid (PFBS), trifluoroacetic (TFA) trifluoromethanesulfonic (TFSA). Long present very low (<50 ng/L). It was observed redox conditions influence a number controlling attenuation or behaviour. Most showed accumulation, possibly explained by sorption/desorption transformation processes, highlighting challenges associated remediation. addition, removal different intensities three revealed. Our results help establish principles flow, important development conceptual models plan adopt site specific management activities (e.g., Managed Aquifer Recharge).

Language: Английский

Citations

3
Development of a procedure based on dispersive solid phase extraction and LC-MS/MS for the analysis of perfluoroalkyl and polyfluoroalkyl substances in food contact materials DOI
Yang Yang, Jin Wang, Jia Qiu

et al.

Journal of Chromatography A, Journal Year: 2025, Volume and Issue: 1747, P. 465815 - 465815

Published: Feb. 23, 2025

Language: Английский

Citations

0
The perils of poly- and perfluorinated chemicals on the reproductive health of humans, livestock, and wildlife DOI Creative Commons
Mark P. Green,

Cameron Shearer,

Rebecca Patrick

et al.

Reproduction Fertility and Development, Journal Year: 2024, Volume and Issue: 36(9)

Published: May 14, 2024

Poly- and perfluoroalkyl substances (PFAS) are a prominent class of persistent synthetic compound. The widespread use these in various industrial applications has resulted their pervasive contamination on global scale. It is therefore concerning that PFAS have propensity to accumulate bodily tissues whereupon they been linked with range adverse health outcomes. Despite this, the true extent risk posed by humans, domestic animals, wildlife remains unclear. Addressing questions requires multidisciplinary approach, combining fields chemistry, biology, policy enable meaningful investigation develop innovative remediation strategies. This article combines perspectives chemists, soil scientists, reproductive biologists, researchers, contextualise issue its specific impact health. purpose this describe challenges associated remediating PFAS-contaminated soils waters explore consequences reproduction. Furthermore, current actions promote planetary protect ecosystems presented instigate positive social change among scientific community.

Language: Английский

Citations

2
Occurrence and profiles of perfluoroalkyl substances in wastewaters of chemical industrial parks and receiving river waters: Implications for the environmental impact of wastewater discharge DOI
Shuai Sun, Mengyuan Liang,

Deling Fan

et al.

The Science of The Total Environment, Journal Year: 2024, Volume and Issue: 945, P. 173993 - 173993

Published: June 13, 2024

Language: Английский

Citations

2
Fate of per- and polyfluoroalkyl substances at a 40-year dedicated municipal biosolids land disposal site DOI Creative Commons
R. Álvarez-Ruiz, Linda Lee, Youn Jeong Choi

et al.

The Science of The Total Environment, Journal Year: 2024, Volume and Issue: 954, P. 176540 - 176540

Published: Sept. 25, 2024

The fate of per- and polyfluoroalkyl substances (PFAS) was evaluated at a site where municipal biosolids have been applied annually for 38 years as waste management strategy. Soil cores (1.8 m in 30-cm sections), groundwater from four wells, 2022 were analyzed PFAS (54 targeted, 17 semi-quantified) using liquid chromatography high resolution mass spectrometry including suspect screening. Total concentrations decreased with soil depth 1700 ng/g to 2.06 ng/g. distribution 60 mol% perfluoroalkyl acid (PFAA) precursors intermediates. surface dominated by long-chain PFAAs (67-76 mol%) reflecting precursor degradation after application. Presence semi-quantified intermediates further reflects soil. Long-chain diminished while short-chain increased up 98 96 the bottom groundwater, respectively. is consistent chain-length dependent sorption-impacted transport organic carbon content (15.2 % OC) which subsequently (~2-3 OC >60 cm). High upper horizon likely decades application rates, contributed minimizing leaching PFAS. While well within dedicated land disposal not drinking water, comparison only, this only marginally exceeded EU water directive total few individual PFAS, but did exceed tenfold, USEPA standard PFOA.

Language: Английский

Citations

2
Mitigation of PFOA/PFOS toxicity in zebrafish (Danio rerio) by oxidative stress modulation and gut microbial metabolism through the use of aquatic probiotic Lactobacillus rhamnosus DOI Creative Commons
Chun Wang, Guanyi Li, Sibao Chen

et al.

Water Cycle, Journal Year: 2024, Volume and Issue: unknown

Published: Oct. 1, 2024

Language: Английский

Citations

2