The Global Decline in Human Fertility: The Post-Transition Trap Hypothesis

Life, Год журнала: 2024, Номер 14(3), С. 369 - 369

Опубликована: Март 11, 2024

Over the past half a century many countries have witnessed rapid fall in total fertility rates, particularly world's most advanced economies including industrial powerhouses of Eastern Asia and Europe. Such nations now passed through first second demographic transitions are currently exhibiting rates well below replacement threshold 2.1, with no sign recovery. This paper examines factors responsible for driving these considers their impact on both fecundity (our fundamental capacity to reproduce). I argue that because transition was extremely largely driven by socioeconomic factors, it has had lasting genetic/epigenetic underpinnings human fecundity. However, will be different. A series conditions associated low societies, relaxed selection pressure high-fertility genotypes, indiscriminate use assisted reproductive technologies treat infertility, environmental contamination toxicants, may our genetic constitution ways compromise future species. Since any change foundations reproduction difficult reverse, we should actively pursue methods monitor fecundity, as sub-replacement levels become established across globe.

Язык: Английский

---

Molecularly imprinted photopolymers combined with smartphone-based optical sensing for selective detection of bisphenol A in foods

Analytical and Bioanalytical Chemistry, Год журнала: 2024, Номер 416(10), С. 2479 - 2492

Опубликована: Март 11, 2024

Язык: Английский

---

Reproductive toxic effects of chronic exposure to bisphenol A and its analogues in marine medaka (Oryzias melastigma)

Aquatic Toxicology, Год журнала: 2024, Номер 271, С. 106927 - 106927

Опубликована: Апрель 17, 2024

Язык: Английский

---

Unravelling bisphenol A-induced hepatotoxicity: Insights into oxidative stress, inflammation, and energy dysregulation

Environmental Pollution, Год журнала: 2024, Номер unknown, С. 124922 - 124922

Опубликована: Сен. 1, 2024

Язык: Английский

---

Advances in understanding the reproductive toxicity of endocrine-disrupting chemicals in women

Frontiers in Cell and Developmental Biology, Год журнала: 2024, Номер 12

Опубликована: Март 28, 2024

Recently, there has been a noticeable increase in disorders of the female reproductive system, accompanied by rise adverse pregnancy outcomes. This trend is increasingly being linked to environmental pollution, particularly through lens Endocrine Disrupting Chemicals (EDCs). These external agents disrupt natural processes hormones, including synthesis, metabolism, secretion, transport, binding, as well elimination. disruptions can significantly impair human functions. A wealth animal studies and epidemiological research indicates that exposure toxic factors interfere with endocrine system’s normal functioning, resulting negative However, mechanisms these effects are largely unknown. work reviews toxicity five major EDCs—Bisphenol (BPA), Phthalates (PAEs), Triclocarban Triclosan Disinfection Byproducts (DBPs)—to lay foundational theoretical basis for further toxicological study EDCs. Additionally, it aims spark advancements prevention treatment caused chemicals.

Язык: Английский

---

The Caenorhabditis elegans neuroendocrine system and their modulators: An overview

Molecular and Cellular Endocrinology, Год журнала: 2024, Номер 586, С. 112191 - 112191

Опубликована: Фев. 20, 2024

Язык: Английский

---

Toxicity of parental co-exposure of microplastic and bisphenol compounds on adult zebrafish: Multi-omics investigations on offspring

The Science of The Total Environment, Год журнала: 2024, Номер 955, С. 176897 - 176897

Опубликована: Окт. 12, 2024

Язык: Английский

---

Maternal exposure to chronic, low-dose nonylphenol in zebrafish: Disruption of ovarian health, reproductive function, and embryogenesis

Journal of Environmental Management, Год журнала: 2025, Номер 375, С. 124169 - 124169

Опубликована: Янв. 21, 2025

Язык: Английский

---

Gestational exposure to PNMC reduces offspring gamete numbers by disrupting oocyte meiosis and spermatogenesis

Ecotoxicology and Environmental Safety, Год журнала: 2025, Номер 292, С. 117980 - 117980

Опубликована: Март 1, 2025

3-Methyl-4-nitrophenol (PNMC) is a prevalent nitrophenolic endocrine disruptor found in pregnant women, with known effects on offspring growth and development. However, its impact fertility remains unexplored. This study investigates the of PNMC exposure during pregnancy underlying mechanisms. Our assessments revealed that reduced number follicles spermatozoa offspring, though it did not affect their quality. In male impaired spermatogenesis by reducing Sertoli cells spermatogonia. female disrupted first meiotic prophase (MPI) oocytes, leading to diplotene oocytes available for primordial follicle assembly. depletion reserve ultimately resulted subfertility. Specifically, hindered homologous recombination-mediated DNA double-strand break repair, triggering activation checkpoint MPI arrest. arrested progression oocytes. provide comprehensive evidence reproductive capacity, elucidating key pathways. These findings emphasize need stricter regulatory measures limit offer new insights into etiology idiopathic oligozoospermia diminished ovarian reserve.

Язык: Английский

---

Multi-mechanistic effects of bisphenol A on testicular dysfunction and endocrine disruption in adult male Labeo bata: oxidative stress, inflammation, and dysregulated energy sensors

Environmental Pollution, Год журнала: 2025, Номер unknown, С. 126231 - 126231

Опубликована: Апрель 1, 2025

Язык: Английский

---