Polypropylene-based
medical
devices
significantly
increased
production
and
usage
in
COVID-19
pandemic
states,
this
material
is
very
resilient
the
environment.
Thus,
rapid
action
needed
to
reduce
pollution
now
more
than
ever.
This
study
focuses
on
degradation
of
polypropylene
microplastics
(PP
MPs)
by
unique
marine
bacterial
strains
obtained
from
Thoundi
(Bacillus
tropicus,
B.
cereus,
Stenotrophomonas
acidaminiphila,
Brucella
pseudintermedia)
Rameshwaram
coasts
(B.
cereus).
Those
above
five
were
chosen
after
preliminary
screening
their
hydrophobicity,
biofilm-forming
capabilities,
responsiveness
zone
clearance
technique.
During
biodegradation
process
(28
days),
these
isolates'
growth,
metabolic
activity,
viability
all
raised.
After
post-biodegradation
process,
weight
loss
percentages
mentioned
treated
with
PP
MPs
gradually
decreased.
UV-DRS
SEM
analysis
confirmed
that
adhering
cause
cracks
cavities
surface.
The
can
be
inferred
alterations
FT-IR
spectrum,
specifically
carbonyl
group
range
1100-1700
cm-1,
as
well
changes
1H
NMR
including
chemical
shift
proton
peak
pattern
alterations.
Bacterial
facilitated
through
secretion
enzymes.
findings
indicate
bacteria
may
possess
distinctive
characteristics
facilitate
plastic
waste
contribute
environmental
conservation.
Environmental Science & Technology,
Год журнала:
2025,
Номер
unknown
Опубликована: Март 19, 2025
Aged
micro(nano)plastics
(MNPs)
are
normally
the
ultimate
state
of
plastics
in
environment
after
aging.
The
changes
physical
and
chemical
characteristics
aged
MNPs
significantly
influence
their
environmental
behavior
by
releasing
additives,
forming
byproducts,
adsorbing
contaminants.
However,
a
systematic
review
is
lacking
on
effects
ecological
human
health
regarding
increasing
but
scattered
studies
results.
This
Review
first
summarizes
unique
methods
for
quantifying
aging
degree.
Then
we
focused
potential
impacts
organisms,
ecosystems,
health,
including
"Trojan
horse"
under
real
conditions.
Through
combining
meta-analysis
analytic
hierarchy
process
(AHP)
model,
demonstrated
that,
compared
to
virgin
MNPs,
would
result
biomass
decrease
oxidative
stress
increase
organisms
lead
total
N/P
greenhouse
gas
emissions
ecosystems
while
causing
cell
apoptosis,
antioxidant
system
reaction,
inflammation
health.
Within
framework
risk
assessment,
used
quotient
(RQ)
physiologically
based
pharmacokinetic
(PBK)
models
as
examples
illustrate
importance
considering
degree
data
acquisition,
model
building,
formula
evaluation.
Given
risks
our
urgent
call
more
understand
hazards
real-world
environments.
Environment International,
Год журнала:
2024,
Номер
191, С. 108949 - 108949
Опубликована: Авг. 15, 2024
Ageing
is
a
nature
process
of
microplastics
that
occurrs
daily,
and
human
beings
are
inevitably
exposed
to
aged
microplastics.
However,
systematic
understanding
ageing
status
its
toxic
effect
currently
still
lacking.
In
this
study,
plastic
cup
lids-originated
polypropylene
(PP)
were
UV-photoaged
until
the
carbonyl
index
(CI),
canonical
indicator
for
ageing,
achieved
0.08,
0.17,
0.22
0.28.
The
adverse
hepatic
these
PPs
(aPPs)
was
evaluated
in
Balb/c
mice
(75
ng/mL
water,
about
200
particles/day)
human-originated
liver
organoids
(LOs,
50
particles/mL,
ranged
from
5.94
13.15
ng/mL)
at
low-dose
equivalent
exposure
level.
Low-dose
PP
could
induce
reductive
stress
both
vitro
vivo,
by
elevating
NADH/NAD+ratio
CI-dependent
manner,
together
with
hepatoxicity
(indicated
increased
AST
secretion
cytotoxicity),
disrupted
genes
encoding
nutrients
transporters
NADH
subunits
accompanied
restricted
ATP
supply,
declined
mitochondrial
membrane
potential
complexI/IV
activities,
without
significant
increase
MDA
levels
liver.
These
changes
metabolism,
representing
circulatory
panel
increases
lactate,
triglyceride,
Fgf21
levels,
decreases
pyruvate
level,
linked
body
weight
gain
but
elevated
contents
following
aPPs
exposure.
Additionally,
assessing
LOs,
it
found
digestion
drastically
accelerated
worsen
energy
supply
upon
mitochondria,
"scattergun
effect"
induced
formation
micro-
nano-plastics
mixture
toward
NADH/NAD+imbalance.
Environment International,
Год журнала:
2024,
Номер
193, С. 109109 - 109109
Опубликована: Ноя. 1, 2024
Micro/Nano
plastics
(MNPs)
pollutants
are
widespread
in
the
environment,
raising
significant
concerns
about
their
biosafety.
Emerging
studies
indicate
that
urinary
system
is
a
primary
accumulation
site
for
MNPs,
leading
to
severe
tissue
and
functional
damage.
This
review
aims
summarize
recent
research
on
potential
hazards
MNPs
may
pose
system,
highlighting
mechanisms
of
toxicity
current
state
knowledge.
Studies
have
shown
enter
human
body
through
drinking
water,
food
chain,
inhalation,
skin
contact.
They
penetrate
bloodstream
via
digestive,
respiratory,
systems,
subsequently
dispersing
various
organs,
including
system.
The
might
induce
cellular
oxidative
stress,
inflammation,
apoptosis,
autophagy,
"intestine-kidney
axis",
other
possible
toxic
mechanisms.
These
processes
could
disrupt
kidney
metabolic
functions
promote
fibrosis,
thereby
potentially
increasing
risk
diseases.
Despite
ongoing
research,
understanding
MNPs'
impact
remains
limited.
Therefore,
this
provides
comprehensive
overview
highlights
key
challenges,
outlines
future
directions.
It
offers
theoretical
basis
development
effective
protective
measures
policies.
Stem Cell Research & Therapy,
Год журнала:
2025,
Номер
16(1)
Опубликована: Март 26, 2025
Traditional
toxicological
assessment
relied
heavily
on
2D
cell
cultures
and
animal
models
of
study,
which
were
inadequate
for
the
precise
prediction
human
response
to
chemicals.
Researchers
have
now
shifted
focus
organoids
assessment.
Organoids
are
3D
structures
produced
from
stem
cells
that
mimic
shape
functionality
organs
a
number
advantages
compared
traditional
study.
They
capacity
replicate
intricate
cellular
microenvironment
in
vivo
interactions.
offer
physiologically
pertinent
platform
is
useful
researchers
monitor
responses
more
realistic
manner
evaluate
drug
toxicity.
Additionally,
can
be
created
unique
patient,
allowing
individualized
research
providing
understanding
inter-individual
heterogeneity
responses.
Recent
developments
use
gut
liver
xenobiotics
(environmental
toxins
drugs)
reviewed
this
article.
Gut
reveal
potential
damage
digestive
system
how
affect
nutrient
absorption
barrier
function.
Liver
primary
site
detoxification
metabolism
xenobiotics,
usually
routed
gut.
Hence,
these
linked
crucial
evaluating
chemical
or
pollutant
induced
organ
toxicity,
forecasting
their
pharmacokinetics.
When
incorporated
into
development
process,
organoid
improve
accuracy
efficiency
safety
assessments,
leading
safer
effective
treatments.
We
also
discuss
limitations
using
organoid-based
assays,
future
prospects,
including
need
standardized
protocols
overcoming
reproducibility
issues.
