New insights into zinc alleviating renal toxicity of arsenic-exposed carp (Cyprinus carpio) through YAP-TFR/ROS signaling pathway

Pesticide Biochemistry and Physiology, Год журнала: 2024, Номер 205, С. 106153 - 106153

Опубликована: Сен. 25, 2024

Язык: Английский

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Amino acid metabolism disorder and oxidative stress took part in EGCG alleviating Mn-caused ferroptosis via miR-9-5p/got1 axis

Journal of Hazardous Materials, Год журнала: 2025, Номер 489, С. 137656 - 137656

Опубликована: Фев. 21, 2025

Язык: Английский

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Targeting ferroptosis: a new therapeutic opportunity for kidney diseases

Frontiers in Immunology, Год журнала: 2024, Номер 15

Опубликована: Июль 3, 2024

Ferroptosis is a form of non-apoptotic regulated cell death (RCD) that depends on iron and characterized by the accumulation lipid peroxides to lethal levels. involves multiple pathways including redox balance, regulation, mitochondrial function, amino acid, lipid, glycometabolism. Furthermore, various disease-related signaling also play role in regulating process oxidation. In recent years, with emergence concept ferroptosis in-depth study its mechanisms, closely associated biological conditions related kidney diseases, organ development, aging, immunity, cancer. This article reviews development ferroptosis, mechanisms (including GSH-GPX4, FSP1-CoQ1, DHODH-CoQ10, GCH1-BH4, MBOAT1/2 pathways), latest research progress involvement diseases. It summarizes diseases within frameworks metabolism, reactive oxygen biology, biology. The introduces key regulatory factors as well important concepts major open questions natural compounds. hoped future research, further breakthroughs can be made understanding regulation mechanism utilizing promote treatments for such acute injury(AKI), chronic disease (CKD), diabetic nephropathy(DN), renal carcinoma. paves way new approach prevent, treat clinical

Язык: Английский

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Ferroptosis induced by environmental pollutants and its health implications

Cell Death Discovery, Год журнала: 2025, Номер 11(1)

Опубликована: Янв. 24, 2025

Abstract Environmental pollution represents a significant public health concern, with the potential risks associated environmental pollutants receiving considerable attention over an extended period. In recent years, substantial body of research has been dedicated to this topic. Since discovery ferroptosis, iron-dependent programmed cell death typically characterized by lipid peroxidation, in 2012, there have advances study its role and mechanism various diseases. A growing number studies also demonstrated involvement ferroptosis damage caused organism pollutants, molecular mechanisms involved partially elucidated. The targeting be effective means ameliorating PM2.5, organic inorganic ionizing radiation. This review begins providing summary most important ferroptosis. It then proceeds offer critical analysis effects induced pollutants. Furthermore, as is case all rapidly evolving areas, are numerous unanswered questions challenges pertaining pollutant-induced which we discuss attempt provide some directions clues for future field.

Язык: Английский

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Beyond Mortality: Exploring the Influence of Plant Phenolics on Modulating Ferroptosis—A Systematic Review

Antioxidants, Год журнала: 2024, Номер 13(3), С. 334 - 334

Опубликована: Март 10, 2024

Ferroptosis is a recently discovered type of programmed cell death that mechanistically different from other types such as apoptosis, necroptosis, and autophagy. It characterized by the accumulation intracellular iron, overproduction reactive oxygen species, depletion glutathione, extensive lipid peroxidation lipids in membrane. was ferroptosis interconnected with many diseases, neurodegenerative ischemia/reperfusion injury, cancer, chronic kidney disease. Polyphenols, plant secondary metabolites known for bioactivities, are being extensively researched context their influence on which resulted great number publications showing need systematic review. In this review, an literature search performed. Databases (Scopus, Web Science, PubMed, ScienceDirect, Springer) were searched time span 2017 to November 2023, using keyword “ferroptosis” alone combination “flavonoid”, “phenolic acid”, “stilbene”, “coumarin”, “anthraquinone”, “chalcone”; after selection studies, we had 311 papers 143 phenolic compounds. total, 53 compounds showed ability induce ferroptosis, 110 able inhibit out those compounds, 20 both abilities depending model system. The most shikonin, curcumin, quercetin, resveratrol, baicalin. common modes action modulation Nrf2/GPX4 Nrf2/HO-1 axis iron metabolism.

Язык: Английский

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Functional metabolomics reveals arsenic-induced inhibition of linoleic acid metabolism in mice kidney in drinking water

Environmental Pollution, Год журнала: 2024, Номер 349, С. 123949 - 123949

Опубликована: Апрель 16, 2024

Язык: Английский

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Cellular preconditioning and mesenchymal stem cell ferroptosis

World Journal of Stem Cells, Год журнала: 2024, Номер 16(2), С. 64 - 69

Опубликована: Фев. 25, 2024

In this editorial, we comment on the article published in recent issue of

Язык: Английский

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Low-dose bisphenol A plus arsenite: continuous or intermittent exposures in Sprague-Dawley rats; effects on kidney oxidative stress, DNA damage, ferroptosis, and fibrosis

Mutation Research/Genetic Toxicology and Environmental Mutagenesis, Год журнала: 2025, Номер unknown, С. 503871 - 503871

Опубликована: Апрель 1, 2025

Язык: Английский

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Mineralized extracellular matrix composite scaffold incorporated with salvianolic acid A enhances bone marrow mesenchymal stem cell osteogenesis and promotes calvarial bone regeneration

Biomaterials Advances, Год журнала: 2025, Номер unknown, С. 214327 - 214327

Опубликована: Апрель 1, 2025

Язык: Английский

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Epicatechin ameliorates glucose intolerance and hepatotoxicity in sodium arsenite-treated mice

Food and Chemical Toxicology, Год журнала: 2024, Номер 192, С. 114950 - 114950

Опубликована: Авг. 24, 2024

Язык: Английский

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