Chemical Engineering Journal,
Год журнала:
2024,
Номер
498, С. 155025 - 155025
Опубликована: Авг. 23, 2024
Biochar
(pyrolyzed
organic
material)
has
been
increasingly
recognized
for
its
catalytic
role
in
facilitating
the
advanced
oxidation
of
emerging
pollutants.
However,
inherent
capacity
remains
highly
uncontrollable,
leading
to
considerable
uncertainty
when
scaling
up
real-world
applications.
This
study
explores
intensified
biochar
coated
with
CaO2
generating
hydroxyl
radicals
(OH·)
and
tebuconazole,
a
prevalent
fungicide,
tebuconazole
was
selected
as
representative
pesticide
agricultural
drainage.
In
addition
evaluating
potential
degradation
by
processes
(AOPs),
adsorption
capabilities
two
commercially
available
biochars,
one
derived
from
waste
(ABC)
other
spruce
chips
(SBC),
well
their
CaO2-coated
derivatives
(ABC/CaO2
SBC/CaO2),
were
also
assessed.
By
taking
advantage
strong
biochar,
activating
AOPs
at
sites
CaO2,
this
material
enables
more
efficient
targeted
removal
tebuconazole.
The
results
indicate
that
coating
on
promoted
over
tenfold
increase
generation
OH·,
resulting
99%
within
10
min.
Despite
decrease
40–50%
resulted
coating,
10-minutes
overall
performance
significantly
enhanced.
is
closely
related
surface
chemical
properties,
particularly
presence
persistent
free
which
can
be
regenerated.
research
paves
new
way
employing
CaO2-enhanced
mitigation
measures.
Environmental Sciences Europe,
Год журнала:
2024,
Номер
36(1)
Опубликована: Март 7, 2024
Abstract
There
is
an
increasing
imperative
to
explore
safer
alternatives
for
pesticides
due
their
indiscriminate
use
and
consequential
health
impacts
on
the
environment
humans.
Nanoformulations
of
are
being
developed
as
potential
beneficial
properties,
including
enhanced
solubility,
targeted
delivery
site
action,
improved
stability
efficacy
reduced
non-target
effects.
Nevertheless,
a
comprehensive
assessment
necessary
these
emerging
nanopesticides
compared
existing
formulations,
aiming
ascertain
whether
"nano"
characteristics
exacerbate
toxicity
organisms.
This
study
investigated
tebuconazole
(TBZ)
in
different
nanoformulations
(poly-ε-caprolactone
[PCL]
nanostructured
lipid
carrier
[NLC]
loaded
with
TBZ),
well
commercial
formulation,
reproduction
nematode
Caenorhabditis
elegans
both
aqueous
soil
matrices.
Additionally,
impact
correspondent
nanocarriers
without
TBZ
C.
was
examined.
In
water,
form
nano
formulations
exhibited
higher
nematodes'
than
(a.s.)
attributable
freely
dissolved
concentrations
TBZ,
which
resulted
order,
ranging
from
most
least
toxic
follows:
NLC-TBZ
>
PCL-TBZ
formulation
(a.s.).
For
NLC-TBZ,
excess
could
be
clearly
explained
by
combined
nanocarriers,
effect
addition
separate
single
compounds
matching
observed
effects
nanoformulation.
PCL-TBZ,
were
stronger
expected
PCL
potentially
bioavailability
encapsulated
gut
nematodes.
soil,
NLC
showed
other
tested
compounds,
while
did
not
exhibit
negative
.
Microcosm
experiment,
where
long-term
native
fauna
tested,
confirmed
that
TBZ-nanoformulations
act
via
nanocarriers.
These
findings
contribute
valuable
insights
understanding
nanopesticides'
ecotoxicity
underscore
need
harmonized
regulatory
assessments
evaluate
novel
adequately.
Ecotoxicology and Environmental Safety,
Год журнала:
2024,
Номер
284, С. 116865 - 116865
Опубликована: Авг. 12, 2024
Tebuconazole
(TEB),
a
prominent
chiral
triazole
fungicide,
has
been
extensively
utilized
for
plant
pathogen
control
globally.
Despite
experimental
evidence
of
TEB
metabolism
in
mammals,
the
enantioselectivity
biotransformation
R-
and
S-TEB
enantiomers
by
specific
CYP450s
remains
elusive.
In
this
work,
integrated
silico
simulations
were
employed
to
unveil
binding
interactions
enantioselective
metabolic
fate
within
human
CYP1A2,
2B6,
2E1,
3A4.
Molecular
dynamics
(MD)
clearly
delineated
specificity
four
CYP450s,
crucially
determining
their
differences
activity
enantioselectivity.
The
primary
driving
force
robust
ligand
was
identified
as
van
der
Waals
with
particularly
involving
hydrophobic
residues.
Mechanistic
insights
derived
from
quantum
mechanics/molecular
mechanics
(QM/MM)
calculations
established
C
Toxicology Reports,
Год журнала:
2024,
Номер
13, С. 101697 - 101697
Опубликована: Июль 15, 2024
Pesticides
have
increased
crop
yield
but
severely
impacted
ecosystems
and
non-target
organisms.
Flubendiamide,
a
new
generation
pesticide,
targets
insect
larvae
also
affects
This
study
examines
the
effects
of
lowest
observed
effect
concentration
technical
grade
flubendiamide
(0.5
µg/µL)
on
chick
liver,
focusing
cytochrome
P450
(CYP)
enzyme
expression,
oxidative
stress,
liver
damage.
Chick
embryos
treated
with
showed
significant
alterations
in
CYP
mRNA
protein
levels,
indicating
toxicant
accumulation.
Elevated
CYP3A4,
CYP1A1,
CYP1A2,
CYP2C19
levels
were
noted,
suggesting
enhanced
biotransformation
detoxification
processes.
However,
byproducts
led
to
as
evidenced
by
decreased
glutathione
(GSH)
elevated
superoxide
dismutase
(SOD)
catalase
activities.
DCFDA
staining
confirmed
hydrogen
peroxide
(H
Molecules,
Год журнала:
2024,
Номер
29(16), С. 3780 - 3780
Опубликована: Авг. 9, 2024
Molds
pose
a
severe
challenge
to
agriculture
because
they
cause
very
large
crop
losses.
For
this
reason,
synthetic
fungicides
have
been
used
for
long
time.
Without
adequate
protection
against
pests
and
various
pathogens,
losses
could
be
as
high
30–40%.
However,
concerns
mainly
about
the
environmental
impact
of
antifungals
human
health
risk
prompted
search
natural
alternatives.
But
do
remedies
only
advantages?
This
article
reviews
current
state
knowledge
on
use
antifungal
substances
in
protect
seeds
phytopathogens.
The
advantages
disadvantages
using
both
cereal
grains
were
discussed,
indicating
specific
examples
mechanisms
action.
possibilities
an
integrated
control
approach,
combining
cultural,
biological,
chemical
methods
are
described,
constituting
holistic
strategy
sustainable
mold
management
grain
industry.
Polymers,
Год журнала:
2024,
Номер
16(23), С. 3281 - 3281
Опубликована: Ноя. 25, 2024
Seed
coating
technology
is
vital
in
agriculture,
enhancing
seed
protection
and
growth.
However,
conventional
coatings
often
include
chemical
fungicides
that
pose
environmental
risks,
highlighting
the
need
for
sustainable
alternatives.
This
study
explores
silk
fibroin
(SF),
a
natural
biopolymer
with
excellent
film-forming
properties,
as
potential
agent,
addressing
its
antimicrobial
limitations
by
combining
it
commercial
agent
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