Chronic tributyltin exposure induces metabolic disruption in an invertebrate model animal, Lymnaea stagnalis

Aquatic Toxicology, Год журнала: 2025, Номер 284, С. 107404 - 107404

Опубликована: Май 9, 2025

Over the last 20 years, tributyltin (TBT) has been reported to cause metabolic disruption in both invertebrates and vertebrates, highlighting need for further detailed analysis of its physiological effects. This study aimed investigate metabolic-disrupting effects TBT from behavioral molecular level. Adult specimens great pond snail (Lymnaea stagnalis) were exposed an environmentally relevant concentration (100 ng L-1) 21 days. After chronic exposure, alterations as well histological, cellular, changes investigated central nervous system, kidney, hepatopancreas. exposure significantly decreased feeding activity, while locomotor activity remained unchanged. At histological level, cellular localization tin was demonstrated all tissues and, addition, characteristic morphological observed kidney Tissue-specific lipid profiles confirmed TBT-induced homeostasis mollusks, characterized by a consistent reduction proportion polyunsaturated fatty acids shift toward more saturated lipids. The expression 17β-hydroxysteroid dehydrogenase type 12 (HSD17B12) enzyme, involved metabolism reduced three after exposure. Our results show that induces significant multi-level Lymnaea, including direct composition. findings also suggest HSD17B12 enzyme plays key role mammals, is likely disruption. Overall, our extends previous studies on mollusks providing novel tissue-specific data highlights complexity evolutionary conserved way

Язык: Английский

Evaluation of the citalopram toxicity on early development of zebrafish: Morphological, physiological and biochemical responses

Environmental Pollution, Год журнала: 2024, Номер 357, С. 124399 - 124399

Опубликована: Июнь 19, 2024

Язык: Английский

Developmental, behavioral, and biochemical effects of chronic exposure to sublethal concentrations of organic UV-filter compounds on a freshwater model species

Aquatic Toxicology, Год журнала: 2024, Номер 277, С. 107134 - 107134

Опубликована: Окт. 30, 2024

Язык: Английский