Chronic tributyltin exposure induces metabolic disruption in an invertebrate model animal, Lymnaea stagnalis
Aquatic Toxicology,
Journal Year:
2025,
Volume and Issue:
284, P. 107404 - 107404
Published: May 9, 2025
Over
the
last
20
years,
tributyltin
(TBT)
has
been
reported
to
cause
metabolic
disruption
in
both
invertebrates
and
vertebrates,
highlighting
need
for
further
detailed
analysis
of
its
physiological
effects.
This
study
aimed
investigate
metabolic-disrupting
effects
TBT
from
behavioral
molecular
level.
Adult
specimens
great
pond
snail
(Lymnaea
stagnalis)
were
exposed
an
environmentally
relevant
concentration
(100
ng
L-1)
21
days.
After
chronic
exposure,
alterations
as
well
histological,
cellular,
changes
investigated
central
nervous
system,
kidney,
hepatopancreas.
exposure
significantly
decreased
feeding
activity,
while
locomotor
activity
remained
unchanged.
At
histological
level,
cellular
localization
tin
was
demonstrated
all
tissues
and,
addition,
characteristic
morphological
observed
kidney
Tissue-specific
lipid
profiles
confirmed
TBT-induced
homeostasis
mollusks,
characterized
by
a
consistent
reduction
proportion
polyunsaturated
fatty
acids
shift
toward
more
saturated
lipids.
The
expression
17β-hydroxysteroid
dehydrogenase
type
12
(HSD17B12)
enzyme,
involved
metabolism
reduced
three
after
exposure.
Our
results
show
that
induces
significant
multi-level
Lymnaea,
including
direct
composition.
findings
also
suggest
HSD17B12
enzyme
plays
key
role
mammals,
is
likely
disruption.
Overall,
our
extends
previous
studies
on
mollusks
providing
novel
tissue-specific
data
highlights
complexity
evolutionary
conserved
way
Language: Английский
Evaluation of the citalopram toxicity on early development of zebrafish: Morphological, physiological and biochemical responses
Sundaram Mohanthi,
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Jesudass Sutha,
No information about this author
Murugesh Gayathri
No information about this author
et al.
Environmental Pollution,
Journal Year:
2024,
Volume and Issue:
357, P. 124399 - 124399
Published: June 19, 2024
Language: Английский
Developmental, behavioral, and biochemical effects of chronic exposure to sublethal concentrations of organic UV-filter compounds on a freshwater model species
Aquatic Toxicology,
Journal Year:
2024,
Volume and Issue:
277, P. 107134 - 107134
Published: Oct. 30, 2024
Language: Английский