PLoS ONE, Год журнала: 2024, Номер 19(9), С. e0307514 - e0307514

Опубликована: Сен. 24, 2024

Background Rheumatoid arthritis is a common rheumatic disease, and its onset closely related to genetic environmental factors, however, the relationship between air pollution RA still hotly debated. Further investigation of rheumatoid conducive comprehensive understanding risk factors providing certain value for clinical prevention treatment RA. Methods We used Two-Sample Mendelian Randomization approach, integrating large-scale public genomewide association study, assess genetically predicted causal effect (including: PM2.5, PM2.5–10, PM10, nitrogen dioxide, oxides) on in European East Asian populations, respectively. Indicators (2,505 individuals 423,796 individuals), including populations were obtained from Integrative Epidemiology Unit open GWAS project. Published data also IEU project (212,453 while publicly available finngen R10 (13,621 cases 262,844 controls). Inverse variance weighting was as primary analytical method, complemented by MR-egger, Weighed median, Weighted mode results. Cochran Q tested heterogeneity, MR-Egger regression analyses performed test multiplicity. leave-one-out analysis allowed robustness reliability assessed. Results No statistically significant effects oxides observed either or populations. data: PM2.5 (IVW OR: 0.71; 95% CI: 0.27–1.91; p = 0.498; number SNPs: 5), PM2.5–10 1.20; 0.61–2.40; 0.596; 15), PM10 1.69; 0.84–3.39; 0.142; 9), dioxide 3.88; 0.19–77.77; 0.375; 2), 0.51; 0.16–1.67; 0.268; 4). results: 1.16; 0.98–1.38; 0.086; 4), 1.14; 0.95–1.38; 0.166; 0.95; 0.81–1.11; 0.503; 3), 0.87; 0.76–1.00; 0.051; 6), 0.96; 0.82–1.14; 0.671; 3). signs pleiotropy heterogeneity intercept, MR-PRESSO Cochrane’s (p>0.05). In addition, no outliers found analysis. The results further validated tests, confirming findings. Conclusions transethnic MR suggesting that there may not be

Язык: Английский