Causal associations of air pollution with rheumatoid arthritis: A transethnic Mendelian randomization study DOI Creative Commons
Ao He,

Hainan Li,

Shan Ouyang

et al.

PLoS ONE, Journal Year: 2024, Volume and Issue: 19(9), P. e0307514 - e0307514

Published: Sept. 24, 2024

Background Rheumatoid arthritis is a common rheumatic disease, and its onset closely related to genetic environmental factors, however, the relationship between air pollution RA still hotly debated. Further investigation of rheumatoid conducive comprehensive understanding risk factors providing certain value for clinical prevention treatment RA. Methods We used Two-Sample Mendelian Randomization approach, integrating large-scale public genomewide association study, assess genetically predicted causal effect (including: PM2.5, PM2.5–10, PM10, nitrogen dioxide, oxides) on in European East Asian populations, respectively. Indicators (2,505 individuals 423,796 individuals), including populations were obtained from Integrative Epidemiology Unit open GWAS project. Published data also IEU project (212,453 while publicly available finngen R10 (13,621 cases 262,844 controls). Inverse variance weighting was as primary analytical method, complemented by MR-egger, Weighed median, Weighted mode results. Cochran Q tested heterogeneity, MR-Egger regression analyses performed test multiplicity. leave-one-out analysis allowed robustness reliability assessed. Results No statistically significant effects oxides observed either or populations. data: PM2.5 (IVW OR: 0.71; 95% CI: 0.27–1.91; p = 0.498; number SNPs: 5), PM2.5–10 1.20; 0.61–2.40; 0.596; 15), PM10 1.69; 0.84–3.39; 0.142; 9), dioxide 3.88; 0.19–77.77; 0.375; 2), 0.51; 0.16–1.67; 0.268; 4). results: 1.16; 0.98–1.38; 0.086; 4), 1.14; 0.95–1.38; 0.166; 0.95; 0.81–1.11; 0.503; 3), 0.87; 0.76–1.00; 0.051; 6), 0.96; 0.82–1.14; 0.671; 3). signs pleiotropy heterogeneity intercept, MR-PRESSO Cochrane’s (p>0.05). In addition, no outliers found analysis. The results further validated tests, confirming findings. Conclusions transethnic MR suggesting that there may not be

Language: Английский

A novel concern from two sample Mendelian randomization study: The effects of air pollution exposure on the cardiovascular, respiratory, and nervous system DOI Creative Commons
Yueyao Wang,

Ruiwen Wang,

Zhe Peng

et al.

Ecotoxicology and Environmental Safety, Journal Year: 2024, Volume and Issue: 284, P. 116871 - 116871

Published: Aug. 15, 2024

Cardiovascular, respiratory, and nervous system diseases have high morbidity mortality rates, but the causal relationship between air pollution these remains controversial.

Language: Английский

Citations

4
Long nighttime sleep duration and risk of renal tubular damage: evidence from rural China and a Mendelian randomization analysis DOI Creative Commons

JingJing Quan,

Li Chen, Weilin Chen

et al.

Renal Failure, Journal Year: 2025, Volume and Issue: 47(1)

Published: March 17, 2025

Objective Renal tubular damage, a pivotal pathological feature of chronic kidney disease (CKD), predicts progression. While extreme nighttime sleep duration is linked to glomerular injury by prior studies, its impact on damage remains unclear. Given that 7–9 h per night widely recommended for maintaining overall health, this study aimed assess whether long associated with renal using both observational and genetic evidence.

Language: Английский

Citations

0
Integrating Network Toxicology and Mendelian Randomization to Uncover the Role of AHR in Linking Air Pollution to Male Reproductive Health DOI
Yuqi Li, Zhiyu Liu, Tao Zhou

et al.

Reproductive Toxicology, Journal Year: 2025, Volume and Issue: 135, P. 108918 - 108918

Published: April 14, 2025

Language: Английский

Citations

0
Pesticide exposures and 10-year atherosclerotic cardiovascular disease risk: Integrated epidemiological and bioinformatics analysis DOI
Xueyan Wu, Dandan Wei, Yilin Zhou

et al.

Journal of Hazardous Materials, Journal Year: 2024, Volume and Issue: 485, P. 136835 - 136835

Published: Dec. 10, 2024

Language: Английский

Citations

3
Causal associations of air pollution with rheumatoid arthritis: A transethnic Mendelian randomization study DOI Creative Commons
Ao He,

Hainan Li,

Shan Ouyang

et al.

PLoS ONE, Journal Year: 2024, Volume and Issue: 19(9), P. e0307514 - e0307514

Published: Sept. 24, 2024

Background Rheumatoid arthritis is a common rheumatic disease, and its onset closely related to genetic environmental factors, however, the relationship between air pollution RA still hotly debated. Further investigation of rheumatoid conducive comprehensive understanding risk factors providing certain value for clinical prevention treatment RA. Methods We used Two-Sample Mendelian Randomization approach, integrating large-scale public genomewide association study, assess genetically predicted causal effect (including: PM2.5, PM2.5–10, PM10, nitrogen dioxide, oxides) on in European East Asian populations, respectively. Indicators (2,505 individuals 423,796 individuals), including populations were obtained from Integrative Epidemiology Unit open GWAS project. Published data also IEU project (212,453 while publicly available finngen R10 (13,621 cases 262,844 controls). Inverse variance weighting was as primary analytical method, complemented by MR-egger, Weighed median, Weighted mode results. Cochran Q tested heterogeneity, MR-Egger regression analyses performed test multiplicity. leave-one-out analysis allowed robustness reliability assessed. Results No statistically significant effects oxides observed either or populations. data: PM2.5 (IVW OR: 0.71; 95% CI: 0.27–1.91; p = 0.498; number SNPs: 5), PM2.5–10 1.20; 0.61–2.40; 0.596; 15), PM10 1.69; 0.84–3.39; 0.142; 9), dioxide 3.88; 0.19–77.77; 0.375; 2), 0.51; 0.16–1.67; 0.268; 4). results: 1.16; 0.98–1.38; 0.086; 4), 1.14; 0.95–1.38; 0.166; 0.95; 0.81–1.11; 0.503; 3), 0.87; 0.76–1.00; 0.051; 6), 0.96; 0.82–1.14; 0.671; 3). signs pleiotropy heterogeneity intercept, MR-PRESSO Cochrane’s (p>0.05). In addition, no outliers found analysis. The results further validated tests, confirming findings. Conclusions transethnic MR suggesting that there may not be

Language: Английский

Citations

0