Comparison of intestinal toxicity in enhancing intestinal permeability and in causing ROS production of six PPD quinones in Caenorhabditis elegans

The Science of The Total Environment, Год журнала: 2024, Номер 927, С. 172306 - 172306

Опубликована: Апрель 7, 2024

Язык: Английский

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Exposure to 6-PPD quinone causes ferroptosis activation associated with induction of reproductive toxicity in Caenorhabditis elegans

Journal of Hazardous Materials, Год журнала: 2024, Номер 471, С. 134356 - 134356

Опубликована: Апрель 19, 2024

Язык: Английский

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Exposure to 6-PPD quinone causes damage on mitochondrial complex I/II associated with lifespan reduction in Caenorhabditis elegans

Journal of Hazardous Materials, Год журнала: 2024, Номер 472, С. 134598 - 134598

Опубликована: Май 13, 2024

Язык: Английский

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Environmental profiles, hazard identification, and toxicological hallmarks of emerging tire rubber-related contaminants 6PPD and 6PPD-quinone

Environment International, Год журнала: 2024, Номер 187, С. 108677 - 108677

Опубликована: Апрель 21, 2024

N-(1,3-dimethylbutyl)-N'-phenyl-p-phenylenediamine (6PPD) is commonly used in rubber compounds as antioxidants to protect against degradation from heat, oxygen, and ozone exposure. This practice extends the lifespan of products, including tires, by preventing cracking, aging, deterioration. However, environmental consequences waste generated during product use, particularly formation 6PPD-quinone (6PPD-Q) through reaction 6PPD with ozone, have raised significant concerns due their detrimental effects on ecosystems. Extensive research has revealed widespread occurrence its derivate 6PPD-Q various compartments, air, water, soil. The emerging substance been shown pose acute mortality long-term hazards aquatic terrestrial organisms at concentrations below environmentally relevant levels. Studies demonstrated toxic a range organisms, zebrafish, nematodes, mammals. These include neurobehavioral changes, reproductive dysfunction, digestive damage exposure pathways. Mechanistic insights suggest that mitochondrial stress, DNA adduct formation, disruption lipid metabolism contribute toxicity induced 6PPD-Q. Recent findings human samples, such blood, urine, cerebrospinal fluid, underscore importance further public health toxicological implications these compounds. distribution, fate, biological effects, underlying mechanisms environment highlight urgent need for additional understand address impacts

Язык: Английский

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Polylactic acid microplastics cause transgenerational reproductive toxicity associated with activation of insulin and hedgehog ligands in C. elegans

The Science of The Total Environment, Год журнала: 2024, Номер 942, С. 173746 - 173746

Опубликована: Июнь 7, 2024

Язык: Английский

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Neurotoxicity and accumulation of CPPD quinone at environmentally relevant concentrations in Caenorhabditis elegans

Chemosphere, Год журнала: 2024, Номер 361, С. 142499 - 142499

Опубликована: Май 31, 2024

Язык: Английский

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Potential human health risk of the emerging environmental contaminant 6-PPD quinone

The Science of The Total Environment, Год журнала: 2024, Номер 949, С. 175057 - 175057

Опубликована: Июль 26, 2024

Язык: Английский

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Transgenerational Response of Germline Nuclear Hormone Receptor Genes to Nanoplastics at Predicted Environmental Doses in Caenorhabditis elegans

Toxics, Год журнала: 2024, Номер 12(6), С. 420 - 420

Опубликована: Июнь 7, 2024

Transgenerational nanoplastic toxicity could be detected in Caenorhabditis elegans after exposure at the parental generation (P0-G); however, underlying mechanisms remain largely unclear. We aimed to examine role of germline nuclear hormone receptors (NHRs) controlling transgenerational polystyrene nanoparticles (PS-NPs) based on gene expression screening and functional analysis. Among NHR genes, daf-12, nhr-14, nhr-47 expressions were increased nhr-12 was decreased by PS-NPs (1 10 μg/L). alterations these four genes also induced RNAi caused resistance, whereas conferred susceptibility PS-NP toxicity. After exposure, ins-3, daf-28, ins-39 encoding insulin ligands, efn-3 Ephrin ligand, lin-44 Wnt as well their receptor (daf-2, vab-1, and/or mig-1), dysregulated nhr-47, nhr-12. Therefore, alteration certain NHRs mediate induction affecting secreted ligands offspring exposed organisms.

Язык: Английский

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Mixture toxicity of 6PPD-quinone and polystyrene nanoplastics in zebrafish

Environmental Pollution, Год журнала: 2024, Номер 348, С. 123835 - 123835

Опубликована: Март 21, 2024

Plastic pollution, including micro- and nanoplastics, is a growing concern. Tyre-wear particles (TWPs) are the second largest source of microplastics in ocean following abrasion synthetic fibres. In addition to themselves, TWPs contain many harmful chemicals, 6PPD. This chemical reacts with atmospheric ozone forms toxic compound 6PPD-quinone (6PPDq), which poses danger aquatic life. There knowledge gap understanding risks associated combined toxicity nanoplastics (NPs) 6PPDq. The present study aimed investigate NPs 6PPDq on adult zebrafish using phenotypic (behaviour, histology) transcriptomic endpoints. Zebrafish were exposed four treatments: control (contaminant-free), 50 μg/L 6PPDq, 3 mg/L polystyrene (PS)-NPs, combination PS-NPs. We did not observe locomotory dysregulation NPs. However, we found significant hyperlocomotion this effect was even more substantial after co-exposure explores molecular mechanisms behind these effects, identifying genes neurotransmitters fatty acid metabolism that dysregulated by co-exposure. Transcriptomic analysis further showed both PS-NPs impacted cellular processes sterol biosynthesis, cholesterol metabolism, muscle tissue development. effects stronger co-exposed zebrafish, indicating heightened risk integrity mitochondrial dysfunction. These results highlight significance mixture when studying chemicals like

Язык: Английский

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Exposure to 6-PPD quinone enhances glycogen accumulation in Caenorhabditis elegans

Environmental Pollution, Год журнала: 2024, Номер 359, С. 124600 - 124600

Опубликована: Июль 22, 2024

Язык: Английский

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