Melatonin from Plants: Going Beyond Traditional Central Nervous System Targeting—A Comprehensive Review of Its Unusual Health Benefits
Biology,
Год журнала:
2025,
Номер
14(2), С. 143 - 143
Опубликована: Янв. 30, 2025
Melatonin
is
indispensable
for
the
homeostasis
of
plants
and
animals.
In
humans,
it
can
help
prevent
or
be
an
adjuvant
treatment
several
diseases
mainly
related
to
immune
system,
inflammation,
oxidative
stress.
Moreover,
a
melatonin-rich
diet
linked
health
benefits,
such
as
regulation
circadian
rhythm,
immunological
epilepsy
control,
delaying
aging
process,
diminishing
hormones
cancer.
This
review
aimed
show
effects
melatonin
in
beyond
its
traditional
use.
The
results
showed
present
scavenging
free
radicals,
reducing
inflammatory
cytokines,
modulating
system.
improve
insulin
resistance,
blood
pressure,
LDL-c,
adipose
tissue
mass,
adhesion
molecules,
endothelial
impairment,
plaque
formation.
These
result
neuro-
cardioprotection,
improvement
liver
diseases,
rheumatoid
arthritis,
dermatitis,
COVID-19,
polycystic
ovaries,
sepsis.
We
conclude
that
plant
benefit
patients
with
many
besides
sleep
problems
neurodegeneration.
Plant
may
more
cost-effective
fewer
adverse
events
than
synthetic.
However,
clinical
trials
should
performed
adequate
doses,
formulation,
time.
Язык: Английский
Human Gut Microbiome: A Connecting Organ Between Nutrition, Metabolism, and Health
International Journal of Molecular Sciences,
Год журнала:
2025,
Номер
26(9), С. 4112 - 4112
Опубликована: Апрель 26, 2025
The
gut
microbiome
plays
a
vital
role
in
human
health,
functioning
as
metabolic
organ
that
influences
nutrient
absorption
and
overall
well-being.
With
growing
evidence
dietary
interventions
can
modulate
the
improve
this
review
examines
whether
healthcare
systems
should
prioritize
personalized
microbiome-targeted
therapies,
such
probiotics,
prebiotics,
microbiota
transplants,
over
traditional
pharmaceutical
treatments
for
chronic
diseases
like
obesity,
diabetes,
cardiovascular
risk,
inflammatory
conditions.
A
systematic
using
Web
of
Science
Scopus
databases
was
conducted,
followed
by
scientometric
analysis.
Key
pathways,
fiber
fermentation
short-chain
fatty
acid
production,
were
explored,
focusing
on
their
impact
lipid
glucose
metabolism.
interactions
between
microbial
metabolites
immune
system
also
investigated.
Dietary
interventions,
including
increased
probiotic
intake,
show
potential
addressing
dysbiosis
linked
to
conditions,
type
2
autoimmune
diseases.
emphasizes
need
incorporate
modulation
strategies
into
clinical
practice
research,
calling
multidisciplinary
approach
integrates
nutrition,
microbiology,
biochemistry
better
understand
microbiome’s
complex
health.
Язык: Английский
Effect of melatonin on gut microbiome and metabolomics in diabetic cognitive impairment
Frontiers in Pharmacology,
Год журнала:
2024,
Номер
15
Опубликована: Ноя. 21, 2024
Diabetic
cognitive
impairment(DCI)
presents
as
a
central
nervous
complication
of
diabetes
especially
among
aging
population.
Melatonin
(MEL)
is
known
for
its
antioxidant
and
anti-inflammation
effects
in
neuroprotective
aspects.
Recent
evidence
has
demonstrated
that
the
gut
microbiome
plays
key
role
DCI
by
modulating
function
through
gut-brain
crosstalk.
MEL
been
shown
to
modulate
microbiota
composition
diabetic
model.
However,
underlying
mechanism
which
contributes
remains
unclear.
This
study
aims
investigate
effect
attenuating
relation
regulating
metabolomics.
Cognitive
memory
were
assessed
Morris
water
maze
test,
histopathological
assessment
brain
tissues,
immunoblotting
neuroinflammation
apoptosis.
The
levels
serum
tumor
necrosis
factor-α
(TNF-α)
Interleukin-18
(IL-18)
measured
enzyme-linked
immunoassays
reflect
circulatory
inflammation
level.16S
rRNA
sequencing
analysis
was
performed
on
control
mice(db-m
group),
mice(db-db
group)
MEL-treated
mice(db-dbMEL
group).
Gut
metabolites
changes
characterized
using
liquid
chromatography
tandem
mass
spectrometry
(LC-MS/MS).
Our
confirmed
alleviated
diabetes-induced
cognition
dysfunction.
protected
against
apoptosis
hippocampus
db-db
mice.
corrected
increased
abundance
Bacteroides
Dorea
reduced
Prevotella
vast
majority
differential
three
groups
lipids
lipid-like
molecules.
significantly
restored
pyruvate
lactic
acid.
results
supported
use
promising
therapeutic
agent
DCI,
may
be
associated
with
metabolomics
regulation.
Язык: Английский