Melatonin from Plants: Going Beyond Traditional Central Nervous System Targeting—A Comprehensive Review of Its Unusual Health Benefits

Biology, Journal Year: 2025, Volume and Issue: 14(2), P. 143 - 143

Published: Jan. 30, 2025

Melatonin is indispensable for the homeostasis of plants and animals. In humans, it can help prevent or be an adjuvant treatment several diseases mainly related to immune system, inflammation, oxidative stress. Moreover, a melatonin-rich diet linked health benefits, such as regulation circadian rhythm, immunological epilepsy control, delaying aging process, diminishing hormones cancer. This review aimed show effects melatonin in beyond its traditional use. The results showed present scavenging free radicals, reducing inflammatory cytokines, modulating system. improve insulin resistance, blood pressure, LDL-c, adipose tissue mass, adhesion molecules, endothelial impairment, plaque formation. These result neuro- cardioprotection, improvement liver diseases, rheumatoid arthritis, dermatitis, COVID-19, polycystic ovaries, sepsis. We conclude that plant benefit patients with many besides sleep problems neurodegeneration. Plant may more cost-effective fewer adverse events than synthetic. However, clinical trials should performed adequate doses, formulation, time.

Language: Английский

Human Gut Microbiome: A Connecting Organ Between Nutrition, Metabolism, and Health

International Journal of Molecular Sciences, Journal Year: 2025, Volume and Issue: 26(9), P. 4112 - 4112

Published: April 26, 2025

The gut microbiome plays a vital role in human health, functioning as metabolic organ that influences nutrient absorption and overall well-being. With growing evidence dietary interventions can modulate the improve this review examines whether healthcare systems should prioritize personalized microbiome-targeted therapies, such probiotics, prebiotics, microbiota transplants, over traditional pharmaceutical treatments for chronic diseases like obesity, diabetes, cardiovascular risk, inflammatory conditions. A systematic using Web of Science Scopus databases was conducted, followed by scientometric analysis. Key pathways, fiber fermentation short-chain fatty acid production, were explored, focusing on their impact lipid glucose metabolism. interactions between microbial metabolites immune system also investigated. Dietary interventions, including increased probiotic intake, show potential addressing dysbiosis linked to conditions, type 2 autoimmune diseases. emphasizes need incorporate modulation strategies into clinical practice research, calling multidisciplinary approach integrates nutrition, microbiology, biochemistry better understand microbiome’s complex health.

Language: Английский

Effect of melatonin on gut microbiome and metabolomics in diabetic cognitive impairment

Frontiers in Pharmacology, Journal Year: 2024, Volume and Issue: 15

Published: Nov. 21, 2024

Diabetic cognitive impairment(DCI) presents as a central nervous complication of diabetes especially among aging population. Melatonin (MEL) is known for its antioxidant and anti-inflammation effects in neuroprotective aspects. Recent evidence has demonstrated that the gut microbiome plays key role DCI by modulating function through gut-brain crosstalk. MEL been shown to modulate microbiota composition diabetic model. However, underlying mechanism which contributes remains unclear. This study aims investigate effect attenuating relation regulating metabolomics. Cognitive memory were assessed Morris water maze test, histopathological assessment brain tissues, immunoblotting neuroinflammation apoptosis. The levels serum tumor necrosis factor-α (TNF-α) Interleukin-18 (IL-18) measured enzyme-linked immunoassays reflect circulatory inflammation level.16S rRNA sequencing analysis was performed on control mice(db-m group), mice(db-db group) MEL-treated mice(db-dbMEL group). Gut metabolites changes characterized using liquid chromatography tandem mass spectrometry (LC-MS/MS). Our confirmed alleviated diabetes-induced cognition dysfunction. protected against apoptosis hippocampus db-db mice. corrected increased abundance Bacteroides Dorea reduced Prevotella vast majority differential three groups lipids lipid-like molecules. significantly restored pyruvate lactic acid. results supported use promising therapeutic agent DCI, may be associated with metabolomics regulation.

Language: Английский