Association between urinary exposures and the risk of chronic obstructive pulmonary disease in smokers: results from NHANES 2007–2016

Frontiers in Public Health, Год журнала: 2025, Номер 13

Опубликована: Апрель 4, 2025

Objective This study aims to shed light on the connection of urinary exposures with risk chronic obstructive pulmonary disease (COPD) among smokers, thereby providing scientific evidence for prevention and intervention COPD. Methods Data National Health Nutrition Examination Survey (NHANES) 2007–2016 were utilized, including 3,973 smokers aged 20 or older. We employed weighted multivariate logistic quantile sum (WQS) regression models delve into link concentrations COPD risk. Additionally, restricted cubic spline was utilized examine dose–response relationship between biomarker The stability associations across different participant characteristics evaluated through subgroup mediation analyses. Results Our encompassed a total participants, whom 472 diagnosed Regression analyses revealed inverse association benzophenone-3 (BP-3) propyl paraben (PrP) Higher quartiles BP-3 PrP exhibited lower incidence [BP-3: odds ratio (OR) = 0.64, 95% confidence interval (95%CI) (0.47, 0.89), p 0.007; PrP: OR 0.56, 95%CI (0.36, 0.86), 0.008]. Significant synergistic interactions observed [WQS: 0.75, (0.65, 0.88), 0.026], contributing 40.31 40.01% analysis, respectively. Mediation analysis proved that inflammatory markers, such as white blood cell (WBC) count neutrophil-to-lymphocyte (NLR), significantly mediated BP-3, PrP, (all -values <0.05). Conclusion in environmental exposure have an correlation risk, WBC NLR partially mediating this association.

Язык: Английский

Association between family economic situation and serum PFAS concentration in American adults with hypertension and hyperlipemia

Scientific Reports, Год журнала: 2024, Номер 14(1)

Опубликована: Сен. 5, 2024

Язык: Английский

Perfluoroalkyl Substances and Metabolic Syndrome: A Cross-Sectional Study Using Data from the US National Health and Nutrition Examination Survey

Heliyon, Год журнала: 2024, Номер 10(17), С. e36894 - e36894

Опубликована: Авг. 24, 2024

Epidemiological studies linking metabolic syndrome (MetS) and exposure to perfluoroalkyl substances (PFASs) are limited, the observations gleaned thus far inconclusive. The study was performed explore association of serum PFASs both singly in a mixed manner with MetS, meanwhile examine whether this mediated by albumin US national population.

Язык: Английский