Association of Per- and Polyfluoroalkyl Substance Exposure With Cataract Prevalence Among U.S. Adults: A NHANES Analysis (2005–2008)

Translational Vision Science & Technology, Journal Year: 2025, Volume and Issue: 14(4), P. 1 - 1

Published: April 1, 2025

Cataract, a major health concern among the elderly, can be influenced by environmental exposures. This study examines association between per- and polyfluoroalkyl substance (PFAS) exposure cataract prevalence. Six serum PFAS concentrations were detected 2119 U.S. adults aged 40 years or older based on National Health Nutrition Examination Survey. Multivariable models, including weighted logistic regression, quantile sum (WQS) Bayesian kernel machine used to assess individual overall A mediation analysis was conducted for inflammation biomarkers. Single perfluorohexane sulfonic acid (PFHS) perfluorononanoic (PFNA) found markedly associated with prevalence after adjustment covariates (PFHS: odds ratio [OR], 1.579; 95% CI, 1.003-2.514; PFNA: OR, 1.629; 1.065-2.506). The WQS index significantly (OR, 1.441; 1.130-1.837). PFNA PFHS most influential exposures in mixture. In regression model, exhibited highest group posterior inclusion probability, aligning results. Moreover, albumin neutrophil counts mediate relationship cataract, accounting -26.20% -5.95% of effect, respectively. Exposure positively primarily driven PFNA. Mediation count observed. links prevalence, suggesting reducing could help prevention.

Language: Английский

Association between family economic situation and serum PFAS concentration in American adults with hypertension and hyperlipemia

Scientific Reports, Journal Year: 2024, Volume and Issue: 14(1)

Published: Sept. 5, 2024

Language: Английский

Perfluoroalkyl Substances and Metabolic Syndrome: A Cross-Sectional Study Using Data from the US National Health and Nutrition Examination Survey

Heliyon, Journal Year: 2024, Volume and Issue: 10(17), P. e36894 - e36894

Published: Aug. 24, 2024

Epidemiological studies linking metabolic syndrome (MetS) and exposure to perfluoroalkyl substances (PFASs) are limited, the observations gleaned thus far inconclusive. The study was performed explore association of serum PFASs both singly in a mixed manner with MetS, meanwhile examine whether this mediated by albumin US national population.

Language: Английский