Oral exposure to nanoplastics altered lipid profiles in mouse intestine

Food and Chemical Toxicology, Год журнала: 2025, Номер 197, С. 115304 - 115304

Опубликована: Фев. 2, 2025

Язык: Английский

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Transcriptomic analysis reveals nanoplastics-induced apoptosis, autophagy and immune response in Litopenaeus vannamei

The Science of The Total Environment, Год журнала: 2024, Номер 946, С. 174360 - 174360

Опубликована: Июль 1, 2024

Язык: Английский

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Environmental Exposures and Polycystic Ovary Syndrome: A Review

Seminars in Reproductive Medicine, Год журнала: 2025, Номер unknown

Опубликована: Фев. 5, 2025

Abstract Polycystic ovary syndrome (PCOS) is the most common heterogeneous endocrine disorder in women of reproductive age, affecting around 5 to 10% and up 21% depending on applied diagnostic criteria study population. People with PCOS may experience oligomenorrhea, androgen excess, polycystic morphology. The etiology disease not completely understood, genetics, epigenetics, endocrine, metabolic, lifestyle, environmental factors contributing its development severity. Environmental exposures are an important, burgeoning field menstrual research, as they potentially link cycle disruption risk disorders such PCOS. This review examines recent research investigating exposures—air pollution, micro- nanoplastics, heavy metals, endocrine-disrupting chemicals—and human animal models, concluding potential mechanisms, limitations, considerations for future work. Overall, limited yields results across studies. Specifically, air pollutants, persistent organic parabens have noticeably research. Future can help fill gap understanding how exposures, particularly gestational, childhood, adult life stages, impact

Язык: Английский

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Effects of Sub-Chronic Exposure to Polystyrene Nanoplastics on Lipid and Antioxidant Metabolism in Sparus aurata

Animals, Год журнала: 2025, Номер 15(4), С. 562 - 562

Опубликована: Фев. 14, 2025

Nanoplastics (NPs) can cross cellular membranes and affect performance. This study aims to determine the effects of polystyrene NPs (PS-NPs, 44 nm) on gilthead seabream (Sparus aurata) exposed for 14 days 100 μg/L PS-NPs. The results show that biometric indicators (weight, length, Fulton's condition factor, hepatosomatic index) were not affected after experimental exposures. No significant observed white blood cell count, red mean corpuscular hemoglobin, or platelets compared control group. However, there was a decrease in hemoglobin concentration, hematocrit values, volume fish There no plasmatic cholesterol, triglyceride, alkaline phosphatase, aspartate aminotransferase levels. histological anatomy both gills intestine revealed obvious signs damage, excessive mucous, inflammation PS-NP expression transcripts related lipid metabolism (pparα, pparβ), growth development (igf1), detoxification (bche), oxidative stress (sod, gpx1) significantly downregulated animals PS-NPs, indicating slight impairment homeostasis antioxidant response.

Язык: Английский

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Polystyrene Nanoplastics Chronic Exposure Cause Zebrafish Visual Neurobehavior Toxicity Through TGFβ-Crystallin Axis

Journal of Hazardous Materials, Год журнала: 2025, Номер unknown, С. 138255 - 138255

Опубликована: Апрель 1, 2025

Язык: Английский

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Efficacy of DHA-enriched phosphatidylserine and its underlying mechanism in alleviating polystyrene nanoplastics-induced hepatotoxicity in mice

International Immunopharmacology, Год журнала: 2024, Номер 142, С. 113154 - 113154

Опубликована: Сен. 14, 2024

Язык: Английский

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Integration of physiology, microbiota and metabolomics reveals toxic response of zebrafish gut to co-exposure to polystyrene nanoplastics and arsenic

Aquatic Toxicology, Год журнала: 2024, Номер 278, С. 107172 - 107172

Опубликована: Ноя. 19, 2024

Язык: Английский

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Zebrafish and Drosophila as Model Systems for Studying the Impact of Microplastics and Nanoplastics ‐ A Systematic Review

Environmental Quality Management, Год журнала: 2024, Номер 34(3)

Опубликована: Дек. 28, 2024

ABSTRACT Microplastics and nanoplastics (MNPs) are byproducts of plastics created to benefit humanity, but improper disposal inadequate recycling have turned them into a global menace that we can no longer conceal. As they interact with all living organisms, including humans, their mechanism interaction perilous impact must be meticulously investigated. To uncover the secrets MNPs, there model systems exist interlink two major scenarios: represent environmental relevant humans. Therefore, zebrafish Drosophila perfect describe these cases, as well studied relatable In this review, 39% studies reported higher mortality hatching rates at greater MNP concentrations, severe oxidative stress seen by raised malondialdehyde (MDA) levels, reduced superoxide dismutase (SOD) activity. About 50% showed neurotoxic behavior drop locomotor activity, suggesting neurotoxicity. MNPs significant on fertility rate . More than half revealed genotoxicity in observed wing spot assays modified genomic expressions associated detoxification processes. These findings emphasize potential bioaccumulate, impair physiological systems, cause neurobehavioral damage. This study underscores importance for thorough risk evaluations health consequences.

Язык: Английский

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Autophagy and PPARs/NF-κB-associated inflammation are involved in hepatotoxicity induced by the synthetic phenolic antioxidant 2,4-di-tert-butylphenol in common carp (Cyprinus carpio)

Ecotoxicology and Environmental Safety, Год журнала: 2024, Номер 284, С. 116937 - 116937

Опубликована: Сен. 2, 2024

The synthetic phenolic antioxidant 2,4-di-tert-butylphenol (2,4-DTBP) is an emergent contaminant and can disrupt the delicate balance of aquatic ecosystems. This study aimed to investigate 2,4-DTBP-induced hepatotoxicity in common carp underlying mechanisms involved. Sixty were divided into four groups exposed 0 mg/L, 0.01 0.1 mg/L or 1 2,4-DTBP for 30 days. Here, we first demonstrated that exposure caused liver damage, manifested as hepatocyte nuclear pyknosis, inflammatory cell infiltration apoptosis. Moreover, induced hepatic reactive oxygen species (ROS) overload disrupted capacity, indicated by reduced activity enzymes superoxide dismutase (SOD), catalase (CAT) glutathione peroxidase (GSH-Px). In addition, transmission electron microscopy revealed autophagosome accumulation carp. Western blot analysis further significantly decreased protein levels mTOR increased LC3II/LC3I ratio. Furthermore, inhibited lysozyme (LZM) alkaline phosphatase (AKP) activity; immunoglobulin M (IgM), complement 3 (C3), 4 (C4) serum; mRNA proinflammatory cytokines (NF-κB, TNF-α, IL-1β IL-6); three types proliferator-activated receptors (PPARs) (α, β/δ γ). Molecular docking directly binds internal active pocket PPARs. Overall, concluded systems could induce regulating autophagy controlling responses. present provides new insights mechanism organisms furthers our understanding effects on public health ecotoxicology.

Язык: Английский

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Deep Learning-assisted Detection of Psychoactive Water Pollutants Using Behavioral Profiling of Zebrafish Embryos

Journal of Hazardous Materials, Год журнала: 2024, Номер 480, С. 136358 - 136358

Опубликована: Окт. 30, 2024

Язык: Английский

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