Cited by Deep Learning-assisted Detection of Psychoactive Water Pollutants Using Behavioral Profiling of Zebrafish Embryos

Oral exposure to nanoplastics altered lipid profiles in mouse intestine DOI

Sihuan Luo,

Xiaomei Zhao,

Yijin Wang

et al.

Food and Chemical Toxicology, Journal Year: 2025, Volume and Issue: 197, P. 115304 - 115304

Published: Feb. 2, 2025

Language: Английский

Citations

Transcriptomic analysis reveals nanoplastics-induced apoptosis, autophagy and immune response in Litopenaeus vannamei DOI

Yiming Li,

Yucong Ye,

Xiaoyi Zhu

et al.

The Science of The Total Environment, Journal Year: 2024, Volume and Issue: 946, P. 174360 - 174360

Published: July 1, 2024

Language: Английский

Citations

Environmental Exposures and Polycystic Ovary Syndrome: A Review DOI

Elizabeth Peebles, Shruthi Mahalingaiah

Seminars in Reproductive Medicine, Journal Year: 2025, Volume and Issue: unknown

Published: Feb. 5, 2025

Abstract Polycystic ovary syndrome (PCOS) is the most common heterogeneous endocrine disorder in women of reproductive age, affecting around 5 to 10% and up 21% depending on applied diagnostic criteria study population. People with PCOS may experience oligomenorrhea, androgen excess, polycystic morphology. The etiology disease not completely understood, genetics, epigenetics, endocrine, metabolic, lifestyle, environmental factors contributing its development severity. Environmental exposures are an important, burgeoning field menstrual research, as they potentially link cycle disruption risk disorders such PCOS. This review examines recent research investigating exposures—air pollution, micro- nanoplastics, heavy metals, endocrine-disrupting chemicals—and human animal models, concluding potential mechanisms, limitations, considerations for future work. Overall, limited yields results across studies. Specifically, air pollutants, persistent organic parabens have noticeably research. Future can help fill gap understanding how exposures, particularly gestational, childhood, adult life stages, impact

Language: Английский

Citations

Effects of Sub-Chronic Exposure to Polystyrene Nanoplastics on Lipid and Antioxidant Metabolism in Sparus aurata DOI

Ekemini Moses Okon, I. Brandts,

Hayam Djafar

et al.

Animals, Journal Year: 2025, Volume and Issue: 15(4), P. 562 - 562

Published: Feb. 14, 2025

Nanoplastics (NPs) can cross cellular membranes and affect performance. This study aims to determine the effects of polystyrene NPs (PS-NPs, 44 nm) on gilthead seabream (Sparus aurata) exposed for 14 days 100 μg/L PS-NPs. The results show that biometric indicators (weight, length, Fulton's condition factor, hepatosomatic index) were not affected after experimental exposures. No significant observed white blood cell count, red mean corpuscular hemoglobin, or platelets compared control group. However, there was a decrease in hemoglobin concentration, hematocrit values, volume fish There no plasmatic cholesterol, triglyceride, alkaline phosphatase, aspartate aminotransferase levels. histological anatomy both gills intestine revealed obvious signs damage, excessive mucous, inflammation PS-NP expression transcripts related lipid metabolism (pparα, pparβ), growth development (igf1), detoxification (bche), oxidative stress (sod, gpx1) significantly downregulated animals PS-NPs, indicating slight impairment homeostasis antioxidant response.

Language: Английский

Citations

Polystyrene Nanoplastics Chronic Exposure Cause Zebrafish Visual Neurobehavior Toxicity Through TGFβ-Crystallin Axis DOI

Jianhua Lin,

Dongliang Pan,

Ying Zhu

et al.

Journal of Hazardous Materials, Journal Year: 2025, Volume and Issue: unknown, P. 138255 - 138255

Published: April 1, 2025

Language: Английский

Citations

Efficacy of DHA-enriched phosphatidylserine and its underlying mechanism in alleviating polystyrene nanoplastics-induced hepatotoxicity in mice DOI

Yuanlei Zhang, Qiaoling Zhao, Rui Zhao

et al.

International Immunopharmacology, Journal Year: 2024, Volume and Issue: 142, P. 113154 - 113154

Published: Sept. 14, 2024

Language: Английский

Citations

Integration of physiology, microbiota and metabolomics reveals toxic response of zebrafish gut to co-exposure to polystyrene nanoplastics and arsenic DOI

Guoxin Li, Min Lv, Haitao Yu

et al.

Aquatic Toxicology, Journal Year: 2024, Volume and Issue: 278, P. 107172 - 107172

Published: Nov. 19, 2024

Language: Английский

Citations

Zebrafish and Drosophila as Model Systems for Studying the Impact of Microplastics and Nanoplastics ‐ A Systematic Review DOI

Sudharsan Sankar, Natarajan Chandrasekaran, Meivelu Moovendhan‬‬‬‬‬‬‬‬

et al.

Environmental Quality Management, Journal Year: 2024, Volume and Issue: 34(3)

Published: Dec. 28, 2024

ABSTRACT Microplastics and nanoplastics (MNPs) are byproducts of plastics created to benefit humanity, but improper disposal inadequate recycling have turned them into a global menace that we can no longer conceal. As they interact with all living organisms, including humans, their mechanism interaction perilous impact must be meticulously investigated. To uncover the secrets MNPs, there model systems exist interlink two major scenarios: represent environmental relevant humans. Therefore, zebrafish Drosophila perfect describe these cases, as well studied relatable In this review, 39% studies reported higher mortality hatching rates at greater MNP concentrations, severe oxidative stress seen by raised malondialdehyde (MDA) levels, reduced superoxide dismutase (SOD) activity. About 50% showed neurotoxic behavior drop locomotor activity, suggesting neurotoxicity. MNPs significant on fertility rate . More than half revealed genotoxicity in observed wing spot assays modified genomic expressions associated detoxification processes. These findings emphasize potential bioaccumulate, impair physiological systems, cause neurobehavioral damage. This study underscores importance for thorough risk evaluations health consequences.

Language: Английский

Citations

Autophagy and PPARs/NF-κB-associated inflammation are involved in hepatotoxicity induced by the synthetic phenolic antioxidant 2,4-di-tert-butylphenol in common carp (Cyprinus carpio) DOI

Jiaqi Xie,

Yuxiang Yin,

Bixiao Lin

et al.

Ecotoxicology and Environmental Safety, Journal Year: 2024, Volume and Issue: 284, P. 116937 - 116937

Published: Sept. 2, 2024

The synthetic phenolic antioxidant 2,4-di-tert-butylphenol (2,4-DTBP) is an emergent contaminant and can disrupt the delicate balance of aquatic ecosystems. This study aimed to investigate 2,4-DTBP-induced hepatotoxicity in common carp underlying mechanisms involved. Sixty were divided into four groups exposed 0 mg/L, 0.01 0.1 mg/L or 1 2,4-DTBP for 30 days. Here, we first demonstrated that exposure caused liver damage, manifested as hepatocyte nuclear pyknosis, inflammatory cell infiltration apoptosis. Moreover, induced hepatic reactive oxygen species (ROS) overload disrupted capacity, indicated by reduced activity enzymes superoxide dismutase (SOD), catalase (CAT) glutathione peroxidase (GSH-Px). In addition, transmission electron microscopy revealed autophagosome accumulation carp. Western blot analysis further significantly decreased protein levels mTOR increased LC3II/LC3I ratio. Furthermore, inhibited lysozyme (LZM) alkaline phosphatase (AKP) activity; immunoglobulin M (IgM), complement 3 (C3), 4 (C4) serum; mRNA proinflammatory cytokines (NF-κB, TNF-α, IL-1β IL-6); three types proliferator-activated receptors (PPARs) (α, β/δ γ). Molecular docking directly binds internal active pocket PPARs. Overall, concluded systems could induce regulating autophagy controlling responses. present provides new insights mechanism organisms furthers our understanding effects on public health ecotoxicology.

Language: Английский

Citations

Deep Learning-assisted Detection of Psychoactive Water Pollutants Using Behavioral Profiling of Zebrafish Embryos DOI

Ya Zhu, Lan Li, Shaokui Yi

et al.

Journal of Hazardous Materials, Journal Year: 2024, Volume and Issue: 480, P. 136358 - 136358

Published: Oct. 30, 2024

Language: Английский

Citations