Per- and Polyfluoroalkyl Substances and Female Health Concern: Gender-based Accumulation Differences, Adverse Outcomes, and Mechanisms

Environmental Science & Technology, Год журнала: 2025, Номер unknown

Опубликована: Янв. 13, 2025

The deleterious health implications of perfluoroalkyl and polyfluoroalkyl substances (PFAS) are widely recognized. Females, in contrast to males, exhibit unique pathways for PFAS exposure excretion, leading complex outcomes. status females is largely influenced by hormone-related processes. have been reported be associated with various aspects female health, including reproductive system disorders pregnancy-related diseases. In this article, we provide insights into the correlations between female-prevalent Current epidemiological toxicological evidence has demonstrated that adverse effects on primarily attributed disruption hypothalamic-pituitary-gonadal (HPG) axis hormonal homeostasis. However, these findings do not sufficiently elucidate intricate associations specific Furthermore, autoimmune disorders, another category more prevalent women compared men, require additional investigation. Immune biomarkers pertinent observed exposure, although insufficient substantiate relations. Further thorough exploration encompassing studies essential elucidating inherent influence human pathologies. Additionally, comprehensive investigations issues beyond their functions essential.

Язык: Английский

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Per- and poly-fluoroalkyl substances (PFAS) in circulation in a Canadian population: their association with serum-liver enzyme biomarkers and piloting a novel method to reduce serum-PFAS

Environmental Health, Год журнала: 2025, Номер 24(1)

Опубликована: Март 15, 2025

Extensive use of per- and polyfluoroalkyl substances (PFAS) has resulted in their ubiquitous presence human blood. PFAS exposures have been associated with multiple adverse health effects. Biomonitoring studies focused on long-chain PFASs, but these are being replaced by short-chain PFASs or alternate chemistries (or replacement such as GenX), resulting changes time. Here, we take advantage serum samples collected part a clinical trial testing the efficacy dietary fiber intervention to reduce cholesterol investigate exposure Canadian participants. Serum were from 72 participants (adult males elevated cholesterol) 2019–2020 at baseline after 4 weeks analyzed for 17 PFASs. The highest geometric mean concentrations measured corresponded PFOSA (7.1 ng/ml), PFOS (4.2, PFOA (1.8 ng/ml) PFHxS (1.3 ng/ml). Four (PFOA, PFOS, PFHxS) two (PFBA, PFHxA) detected 100% GenX was 71% Analyses associations between serum-PFAS biomarkers outcomes showed PFBA, PFHxA, PFDA higher gamma-glutamyl transferase not measures serum-total low-density lipoprotein cholesterol. Comparison 4-week follow-up that total decreased both control groups. However, suite concern identified United States National Academies Sciences, Engineering, Medicine, significantly only group. This observation suggests sustained may body burden, future need sources extend supplement intake beyond weeks. Overall, results show chemistry common this population.

Язык: Английский

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Per- or polyfluoroalkyl substances exposure through human milk, health risk assessment and physical growth in one-year-old children in Shandong, China

Environmental Chemistry and Ecotoxicology, Год журнала: 2025, Номер 7, С. 539 - 546

Опубликована: Янв. 1, 2025

Язык: Английский

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Assessment of PFAS levels in drinking water: A case study from Poznań County (Poland)

Chemosphere, Год журнала: 2025, Номер 377, С. 144326 - 144326

Опубликована: Март 18, 2025

Язык: Английский

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Associations between self-reported consumption of foods and serum PFAS concentrations in a sample of pregnant women in the United States

Environmental Research, Год журнала: 2025, Номер unknown, С. 121461 - 121461

Опубликована: Март 1, 2025

Язык: Английский

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Health Impacts of Per- and Polyfluoroalkyl Substances (PFASs): A Comprehensive Review

Life, Год журнала: 2025, Номер 15(4), С. 573 - 573

Опубликована: Апрель 1, 2025

Per- and polyfluoroalkyl substances (PFASs) are among the persistent organic pollutants characterized by their persistence in environment, high mobility, adverse impact not only on ecosystem but also human health. The biggest challenges biomonitoring low concentrations of PFASs biological matrices presence matrix interferents samples. combination liquid chromatography with tandem mass spectrometry (LC-MS/MS) solid-phase extraction (SPE) as a sample preparation technique appears to be most suitable solution for achieving desired selectivity sensitivity PFAS determination. aim this review is describe possible sources PFASs, various matrices, analytical methods determining different using pretreatment techniques complex samples, well health risks associated exposure. studied include PFOA PFOS, which frequently detected such plasma, serum, breast milk. average range from 1.0 2.6 ng.mL−1 1.9 2.4 0.4 3.1 For were 2.0–4.0 ng.mL−1, 3.7–4.6 3.6–4.8 milk, respectively. significant effects exposure long-chain (such PFOS) lipid disorders, hypertension, diabetes mellitus, thyroid infertility, cancer, obesity, autism, neurodevelopmental issues, cardiovascular diseases, kidney liver disorders. It utmost importance monitor exposure, predict toxicity, develop effective strategies mitigate potential

Язык: Английский

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Prenatal PFAS exposure and outcomes related to maternal gut microbiome composition in later pregnancy

Environmental Research, Год журнала: 2025, Номер unknown, С. 121709 - 121709

Опубликована: Апрель 1, 2025

Язык: Английский

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Cord plasma metabolomic signatures of prenatal per- and polyfluoroalkyl substance (PFAS) exposures in the Boston birth Cohort

Environment International, Год журнала: 2024, Номер 194, С. 109144 - 109144

Опубликована: Ноя. 15, 2024

Prenatal per- and polyfluoroalkyl substance (PFAS) exposures are associated with adverse offspring health outcomes, yet the underlying pathological mechanisms unclear. Cord blood metabolomics can identify potentially important pathways prenatal PFAS exposures, providing mechanistic insights that may help explain PFAS' long-term effects. The study included 590 mother-infant dyads from Boston Birth Cohort. We measured in maternal plasma samples collected 24-72 h after delivery metabolites cord samples. used metabolome-wide association studies pathway enrichment analyses to individual PFAS, quantile-based g-computation models examine associations of mixture. False Discovery Rate account for multiple comparisons. found 331 18 were ≥ 1 38 mixture, predominantly amino acids lipids. Amino such as alanine lysine their pathways, crucial energy generation, biosynthesis, bone health, effects on fetal growth restriction. Carnitines carnitine shuttle pathway, 7 involved mitochondrial fatty acid β-oxidation, which predispose higher risks child restriction cardiovascular diseases. Lipids, glycerophospholipids related contribute insulin resistance diabetes by modulating transporters cell membranes, participating β-cell signaling inducing oxidative damage. Neurotransmission-related including cofactors, precursors, neurotransmitters, neurodevelopment. observed stronger between males. This prospective birth cohort contributes limited literature potential metabolomic perturbations exposures. Future needed replicate our findings link outcomes.

Язык: Английский

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Associations of early life perfluoroalkyl and polyfluoroalkyl substances (PFAS) exposure with body mass index and risk of overweight or obesity at age 2–18 years: Mixture analysis in the prospective Boston Birth Cohort

Environment International, Год журнала: 2024, Номер 195, С. 109206 - 109206

Опубликована: Дек. 15, 2024

Язык: Английский

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An oat fiber intervention for reducing PFAS body burden: A pilot study in male C57Bl/6 J mice

Toxicology and Applied Pharmacology, Год журнала: 2024, Номер 495, С. 117188 - 117188

Опубликована: Дек. 6, 2024

Язык: Английский

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