Aged Biodegradable Nanoplastics Enhance Body Accumulation Associated with Worse Neuronal Damage in Caenorhabditis elegans
Environmental Science & Technology,
Год журнала:
2025,
Номер
unknown
Опубликована: Март 1, 2025
The
environmental
and
health
challenges
posed
by
petroleum-based
biodegradable
plastics,
such
as
polybutylene
succinate
(PBS)
polybutyleneadipate-co-terephthalate
(PBAT),
are
a
significant
concern
because
they
increasingly
present
in
the
environment
contribute
substantial
proportion
of
microplastics
(MPs)
or
nanoplastics
(NPs).
In
this
study,
ultraviolet
(UV)-aged
PBS-NPs
PBAT-NPs
found
to
have
higher
propensity
accumulate
within
body
Caenorhabditis
elegans
(C.
elegans)
prolonging
defecation
interval,
which
could
induce
severe
neuronal
damage
compared
pristine
NPs.
increased
accumulation
(BNPs)
subsequent
impairments
neurobehavior
highly
attributed
their
reduced
particle
size
altered
surface
properties,
including
changed
chemical
bonds
functional
groups
after
photoaging.
Aged
BNPs
also
cause
more
GABAergic
neurons
neurotransmitter
receptors,
resulting
disrupted
homeostasis
behaviors.
Overall,
both
PBS
PBAT
components
show
no
differences
biological
mechanisms
neural
damage,
highlighting
commonalities
characteristics
adverse
effects
on
nervous
system.
Our
study
opens
up
exploration
impacts
photoaging
degradation
state
that
environment.
Язык: Английский
Microplastics and tetracycline affecting apoptosis, enzyme activities and metabolism processes in the Aurelia aurita polyps: insights into combined pollutant effects
Frontiers in Marine Science,
Год журнала:
2025,
Номер
12
Опубликована: Март 14, 2025
Introduction
Microplastics
(MPs)
and
tetracycline
(TC)
are
pervasive
contaminants
in
marine
ecosystems,
yet
their
combined
effects
on
benthic
organisms,
such
as
Aurelia
aurita
polyps,
remain
poorly
understood.
This
study
investigates
the
mechanisms
of
cellular
apoptosis,
oxidative
stress,
metabolic
responses
induced
by
single
exposures
to
MPs
TC.
Methods
Three
experimental
phases
were
conducted:
(1)
A
7-day
exposure
(1
mg/L)
TC
(5
assess
apoptosis
via
TUNEL
assay;
(2)
Short-term
high-concentration
(MPs:
10
mg/L,
TC:
5
for
72
hours,
followed
a
288-hour
recovery
period,
with
antioxidant
indicators
(CAT,
GSH,
SOD,
MDA,
etc.)
measured
at
intervals;
(3)
Long-term
(185
days)
environmentally
relevant
concentrations
(0–1
(0–5
mg/L),
metabolomic
profiling
LC-MS
pathway
analysis.
Polyp
cultures
maintained
under
controlled
conditions,
statistical
analyses
included
two-way
ANOVA
multivariate
models
(PCA,
OPLS-DA).
Results
The
assay
revealed
significantly
higher
rates
MPs+TC
group
compared
controls
or
single-pollutant
groups
(
P
<
0.05).
Antioxidant
capacity
tests
indicated
persistent
damage
even
after
288
hours
recovery.
Metabolomics
identified
distinct
physiological
strategies
TC,
altered
pathways
(e.g.,
ABC
transporters,
protein
digestion)
disrupted
metabolites
(antioxidants,
neurotransmitters).
Notably,
exhibited
non-linear
toxicity,
high
not
consistently
exacerbating
harm.
Discussion
Combined
synergistic
stress
elevating
causing
irreversible
sustained
T-AOC
decline,
MDA
accumulation).
paradoxically
mitigated
co-exposure
groups,
likely
antibacterial
effects.
arachidonic
acid)
neurotransmitter
levels,
impairing
resilience
intercellular
communication.
also
retinoic
acid
indole
derivatives,
potentially
interfering
life-history
transitions.
While
A.
tolerance,
underscores
risks
less
resilient
species.
These
findings
highlight
need
address
cumulative
ecological
impacts
pollutants
through
enhanced
regulation
mechanistic
studies.
Язык: Английский
Comparative genome analysis and global methylation patterns for epigenetic study in the brackish water flea Diaphanosoma celebensis
Comparative Biochemistry and Physiology Part D Genomics and Proteomics,
Год журнала:
2025,
Номер
unknown, С. 101493 - 101493
Опубликована: Март 1, 2025
Язык: Английский
Toxicity comparison of polylactic acid and polyethylene microplastics co-exposed with methylmercury on Daphnia magna
Marine Pollution Bulletin,
Год журнала:
2024,
Номер
211, С. 117318 - 117318
Опубликована: Дек. 2, 2024
Язык: Английский
Adverse effects of environmentally relevant microplastics on in vivo endpoints, oxidative stress, and mitogen-activated protein kinase signaling pathway and multixenobiotic resistance system in the marine rotifer Brachionus plicatilis
The Science of The Total Environment,
Год журнала:
2024,
Номер
958, С. 178027 - 178027
Опубликована: Дек. 18, 2024
Язык: Английский