Research, Год журнала: 2025, Номер 8

Опубликована: Янв. 1, 2025

Plant diseases caused by vegetable viruses are an important threat to global food security, presenting a major challenge for the development of antiviral agrochemicals. Functional proteins plant play crucial role in viral life cycle, and targeted inhibition these has emerged as promising strategy. However, current discovery small molecules is hampered limitations synthetic approaches narrow range targets. Herein, we report practical application organocatalysis serving pesticide that bears unique molecular basis. An N -heterocyclic carbene-modulated reaction first designed asymmetrically functionalize diverse natural phenols with phthalides. Our method capable producing series new phthalidyl ethers under mild conditions good yields, enantioselectivity, functional group tolerance. Among these, compound ( R )- 3w exhibits excellent enantioselectivity-preferred curative activity against potato virus Y (PVY). Mechanistically, it proposed interacts nuclear inclusion body A (Nia) protein PVY at His150 residue. This binding impairs Nia’s function cleavage polyprotein, thereby inhibiting formation replication complex. The study provides insights into advancing protocol facilitate agrochemical discovery, our identified may serve potential lead future research PVY-Nia inhibitors.

Язык: Английский