Carbene-catalyzed Phthalide Ether Functionalization for Discovering Chiral Phytovirucides that Specifically Targets Viral Nia Protein to Inhibit Proliferation DOI Creative Commons
Xiaoyi Wang, Weijia Yang, Shang Wu

et al.

Research, Journal Year: 2025, Volume and Issue: 8

Published: Jan. 1, 2025

Plant diseases caused by vegetable viruses are an important threat to global food security, presenting a major challenge for the development of antiviral agrochemicals. Functional proteins plant play crucial role in viral life cycle, and targeted inhibition these has emerged as promising strategy. However, current discovery small molecules is hampered limitations synthetic approaches narrow range targets. Herein, we report practical application organocatalysis serving pesticide that bears unique molecular basis. An N -heterocyclic carbene-modulated reaction first designed asymmetrically functionalize diverse natural phenols with phthalides. Our method capable producing series new phthalidyl ethers under mild conditions good yields, enantioselectivity, functional group tolerance. Among these, compound ( R )- 3w exhibits excellent enantioselectivity-preferred curative activity against potato virus Y (PVY). Mechanistically, it proposed interacts nuclear inclusion body A (Nia) protein PVY at His150 residue. This binding impairs Nia’s function cleavage polyprotein, thereby inhibiting formation replication complex. The study provides insights into advancing protocol facilitate agrochemical discovery, our identified may serve potential lead future research PVY-Nia inhibitors.

Language: Английский

Translocation, distribution, and metabolism of tolfenpyrad in soil-cultivated and hydroponic endive (Cichorium endivia) and the assessment of potential health risk DOI

Fanxia Liao,

Huijun Zhu,

Shaotao Wu

et al.

Pesticide Biochemistry and Physiology, Journal Year: 2025, Volume and Issue: 210, P. 106370 - 106370

Published: March 4, 2025

Language: Английский

Citations

0
Carbene-catalyzed Phthalide Ether Functionalization for Discovering Chiral Phytovirucides that Specifically Targets Viral Nia Protein to Inhibit Proliferation DOI Creative Commons
Xiaoyi Wang, Weijia Yang, Shang Wu

et al.

Research, Journal Year: 2025, Volume and Issue: 8

Published: Jan. 1, 2025

Plant diseases caused by vegetable viruses are an important threat to global food security, presenting a major challenge for the development of antiviral agrochemicals. Functional proteins plant play crucial role in viral life cycle, and targeted inhibition these has emerged as promising strategy. However, current discovery small molecules is hampered limitations synthetic approaches narrow range targets. Herein, we report practical application organocatalysis serving pesticide that bears unique molecular basis. An N -heterocyclic carbene-modulated reaction first designed asymmetrically functionalize diverse natural phenols with phthalides. Our method capable producing series new phthalidyl ethers under mild conditions good yields, enantioselectivity, functional group tolerance. Among these, compound ( R )- 3w exhibits excellent enantioselectivity-preferred curative activity against potato virus Y (PVY). Mechanistically, it proposed interacts nuclear inclusion body A (Nia) protein PVY at His150 residue. This binding impairs Nia’s function cleavage polyprotein, thereby inhibiting formation replication complex. The study provides insights into advancing protocol facilitate agrochemical discovery, our identified may serve potential lead future research PVY-Nia inhibitors.

Language: Английский

Citations

0