Per- and Polyfluoroalkyl Substances and Female Health Concern: Gender-based Accumulation Differences, Adverse Outcomes, and Mechanisms
Environmental Science & Technology,
Год журнала:
2025,
Номер
unknown
Опубликована: Янв. 13, 2025
The
deleterious
health
implications
of
perfluoroalkyl
and
polyfluoroalkyl
substances
(PFAS)
are
widely
recognized.
Females,
in
contrast
to
males,
exhibit
unique
pathways
for
PFAS
exposure
excretion,
leading
complex
outcomes.
status
females
is
largely
influenced
by
hormone-related
processes.
have
been
reported
be
associated
with
various
aspects
female
health,
including
reproductive
system
disorders
pregnancy-related
diseases.
In
this
article,
we
provide
insights
into
the
correlations
between
female-prevalent
Current
epidemiological
toxicological
evidence
has
demonstrated
that
adverse
effects
on
primarily
attributed
disruption
hypothalamic-pituitary-gonadal
(HPG)
axis
hormonal
homeostasis.
However,
these
findings
do
not
sufficiently
elucidate
intricate
associations
specific
Furthermore,
autoimmune
disorders,
another
category
more
prevalent
women
compared
men,
require
additional
investigation.
Immune
biomarkers
pertinent
observed
exposure,
although
insufficient
substantiate
relations.
Further
thorough
exploration
encompassing
studies
essential
elucidating
inherent
influence
human
pathologies.
Additionally,
comprehensive
investigations
issues
beyond
their
functions
essential.
Язык: Английский
Assessing the Impact of Per- and Polyfluoroalkyl Substances on Pregnancy Loss: An Environmental-Wide Association Study in Northwest China
Опубликована: Янв. 1, 2025
Язык: Английский
Research Progress in Current and Emerging Issues of PFASs’ Global Impact: Long-Term Health Effects and Governance of Food Systems
Foods,
Год журнала:
2025,
Номер
14(6), С. 958 - 958
Опубликована: Март 11, 2025
Per-
and
polyfluoroalkyl
substances
(PFASs)
are
found
everywhere,
including
food,
cosmetics,
pharmaceuticals.
This
review
introduces
PFASs
comprehensively,
discussing
their
nature
identifying
interconnection
with
microplastics
impacts
on
public
health
the
environment.
The
human
cost
of
decades
delay,
cover-ups,
mismanagement
plastic
waste
is
outlined
briefly
explained.
Following
that,
long-term
effects
critically
assessed.
Risk
assessment
then
reviewed,
mentioning
different
tools
models.
Scientific
research
in
United
States
America
analyzed,
taking
into
consideration
Center
for
Disease
Control
(CDC)'s
PFAS
Medical
Studies
Guidelines.
impact
activities
studies
around
world
have
focused
levels
food
products
dietary
intake
countries
such
as
China,
European
countries,
USA
Australia.
Moreover,
drinking
water
regard
to
risks,
mitigation,
regulatory
needs,
account
chemical
contaminants
safety.
Finally,
briefings
specific
regions
discussed,
referring
Australia,
Vietnam,
Canada,
Europe,
(USA),
South
America,
Africa.
crisis
a
multifaceted
issue,
exacerbated
by
mismanagement,
it
discussed
context
applying
following
problem-solving
analytical
tools:
Domino
Effect
Model
accident
causation,
Swiss
Cheese
Theory
Model,
Ishikawa
Fish
Bone
Root
Cause
Analysis.
Last
but
not
least,
PFASs'
Sustainable
Development
Goals
(SDGs)
2030
rigorously
discussed.
Язык: Английский
Assessing the impact of per- and polyfluoroalkyl substances on pregnancy loss: An environmental-wide association study in Northwest China
International Journal of Hygiene and Environmental Health,
Год журнала:
2025,
Номер
266, С. 114568 - 114568
Опубликована: Март 29, 2025
Язык: Английский
Bioinformatics analysis to identify environmental endocrine chemicals that target endometriosis genes
Ecotoxicology and Environmental Safety,
Год журнала:
2025,
Номер
295, С. 118136 - 118136
Опубликована: Апрель 1, 2025
Endometriosis
(EMS)
significantly
impacts
women's
health
and
is
influenced
by
genetic
factors
environmental
endocrine-disrupting
chemicals
(EDCs),
which
interfere
with
hormonal
balance.
Using
the
Gene
Expression
Omnibus
database,
we
identified
differentially
expressed
genes
applied
analytical
methods,
including
WGCNA,
GO,
KEGG,
LASSO
regression,
to
predict
six
key
associated
EMS:
ADAM9,
IRAK3,
NTRK3,
PIK3CG,
STK38,
TLR4.
By
integrating
Comparative
Toxicogenomics
Database
Endocrine
Disruption
Exchange
Database,
35
EDCs
potentially
linked
these
genes.
This
study
highlights
relationship
between
EMS
EDCs,
offering
insights
into
its
pathogenesis
potential
therapeutic
targets
for
improved
treatment.
Язык: Английский