Regulatory insights into nanomedicine and gene vaccine innovation: Safety assessment, challenges, and regulatory perspectives

Acta Biomaterialia, Год журнала: 2024, Номер 180, С. 1 - 17

Опубликована: Апрель 10, 2024

This analysis explores the principal regulatory concerns linked to nanomedicines and gene vaccines, including complexities involved perspectives on how navigate them. In realm of nanomedicines, ensuring safety nanomaterials is paramount due their unique characteristics potential interactions with biological systems. Regulatory bodies are actively formulating guidelines standards assess risks associated nanomedicine products, emphasizing need for standardized characterization techniques accurately gauge effectiveness. Regarding frameworks must be tailored address distinct challenges posed by genetic interventions, necessitating special considerations in efficacy evaluations, particularly concerning vector design, target specificity, long-term patient monitoring. Ethical such as autonomy, informed consent, privacy also demand careful attention, alongside intricate matter intellectual property rights, which balanced against imperative widespread access these life-saving treatments. Collaborative efforts among bodies, researchers, patent offices, private sector essential tackle effectively, international cooperation being especially crucial given global scope vaccine development. Striking right balance between safeguarding properties promoting public health vital fostering innovation equitable ground-breaking technologies, underscoring significance addressing hurdles fully harness benefits vaccines enhancing healthcare outcomes a scale. STATEMENT OF SIGNIFICANCE: Several biomaterials proposed development nanovaccines, from polymeric micelles, PLGA-/PEI-/PLL-nanoparticles, solid lipid nananoparticles, cationic lipoplexes, liposomes, hybrid materials, dendrimers, carbon nanotubes, hydrogels, quantum dots. Lipid nanoparticles (LNPs) have gained tremendous attention since US Food Drug Administration (FDA) approval Pfizer Moderna's COVID-19 raising awareness vaccines. review provides insights into current strategies issues, clinical trials. By navigating landscapes we can unlock full using range promising towards improving worldwide.

Язык: Английский

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Promoting health and sustainability: exploring safer alternatives in cosmetics and regulatory perspectives

Sustainable Chemistry and Pharmacy, Год журнала: 2025, Номер 43, С. 101901 - 101901

Опубликована: Янв. 5, 2025

Язык: Английский

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Machine learning model for prediction of drug solubility in supercritical solvent: Modeling and experimental validation

Journal of Molecular Liquids, Год журнала: 2022, Номер 363, С. 119901 - 119901

Опубликована: Июль 21, 2022

Язык: Английский

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Phytochemical Profile Screening and Selected Bioactivity of Myrtus communis Berries Extracts Obtained from Ultrasound-Assisted and Supercritical Fluid Extraction

Separations, Год журнала: 2025, Номер 12(1), С. 8 - 8

Опубликована: Янв. 3, 2025

This research paper investigates the phytochemical profile, antioxidant activity, antidiabetic potential, and antibacterial activity of Myrtus communis berries. Two extraction methods were employed to obtain extracts: solid–liquid ultrasound-assisted (UAE) supercritical fluid (SFE). The extracts characterized using spectrophotometric Reversed-Phase High-Performance Liquid Chromatography (RP-HPLC). UAE extract exhibited higher total flavonoid anthocyanin content, while SFE prevailed in phenolic content DPPH radical screening assay. RP-HPLC characterization identified quantified several polyphenolic compounds. In extract, epigallocatechin was found a concentration 2656.24 ± 28.15 µg/g dry weight (DW). cafestol compound with highest at level 29.65 0.03 DW. Both contained compounds, including cyanidin 3-O-glucoside chloride, cyanidin-3-O-rutinoside malvidin-3-O-glucoside pelargonidin peonidin peonidin-3-O-rutinoside chloride. potential evaluated vitro by measuring inhibition α-amylase from porcine pancreas (type I-A). results highlighted ability myrtle berry inhibit enzymatic suggesting its as an alternative for controlling postprandial hyperglycemia. showed lowest IC50 value among two extracts, average 8.37 0.52 µg/mL assessed against Bacillus spp., Escherichia coli, Staphylococcus aureus disk diffusion method. similar tested bacterial strains. support further investigation berries ingredient functional food formulation, particularly due antioxidant, antidiabetic, properties.

Язык: Английский

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Exploring the Multifaceted Potential of a Peptide Fraction Derived from Saccharomyces cerevisiae Metabolism: Antimicrobial, Antioxidant, Antidiabetic, and Anti-Inflammatory Properties

Antibiotics, Год журнала: 2023, Номер 12(8), С. 1332 - 1332

Опубликована: Авг. 18, 2023

The rising demand for minimally processed, natural, and healthier food products has led to the search alternative multifunctional bioactive components. Therefore, present study focuses on functional proprieties of a peptide fraction derived from Saccharomyces cerevisiae metabolism. antimicrobial activity is evaluated against various foodborne pathogens, including Candida albicans, krusei, Escherichia coli, Listeria monocytogenes, Salmonella sp. antioxidant properties are assessed using FRAP DPPH scavenging capacity assays. Furthermore, fraction's cytotoxicity in colorectal carcinoma normal colon epithelial cells while its potential as an antidiabetic agent investigated through α-amylase α-glucosidase inhibitory results demonstrate that 2-10 kDa exhibits effects all tested microorganisms, except C. krusei. minimal concentration E. L. remains consistently low, at 0.25 mg/mL, albicans requires higher 1.0 mg/mL. displays activity, evidenced by radical 81.03%, values 1042.50 ± 32.5 µM TE/mL no both tumor non-tumoral human up 0.3 Moreover, presents anti-inflammatory significantly reducing expression TNFα gene more than 29.7% non-stimulated 50% lipopolysaccharide-stimulated cells. It also inhibits carbohydrate digestive enzymes (IC50 199.3 0.9 µg/mL) (IC20 270.6 6.0 µg/mL). Overall, findings showed antibacterial, antioxidant, anti-inflammatory, activity. This represents step forward evaluation biological S. peptides.

Язык: Английский

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Active Ingredients and Carriers in Nutritional Eco-Cosmetics

Compounds, Год журнала: 2023, Номер 3(1), С. 122 - 141

Опубликована: Янв. 20, 2023

Beauty and personal care became a significant part of the global economy for two reasons: (1) The elderly growing in population (2) desire women men to appear younger more attractive. Thus, both young old people are looking revolutionary nutritional eco-cosmetics (combined use cosmeceuticals nutraceuticals) manufactured by natural active ingredients, using biopolymers as substrates, made innovative sustainable technologies. Consequently, market cosmetics diet supplements is continually together with request including bio-peptides biological macromolecules such chitin lignin. Therefore, consumers industry need recover ingredients carriers (vehicles), naturally derived supported advanced methods controlling their effectiveness safeness on skin mucous membrane layers. selected bio-ingredients, hyaluronic acid bio-mimetic peptides, obtained advanced, bio nanotechnologies, will be interest develop smart cosmeceutical nutraceutical formulations. Innovation considered key business strategy drive economic growth. For trying reduce waste produce sustainable, biodegradable products, realization new non-woven tissues, used making nutraceuticals was considered. Both have been from food loss pollution. This review report brief description functions, also focus discuss some clarify supposed mechanism action, carriers, well activity beauty products.

Язык: Английский

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Diversity and biological activities of medicinal plants of Santiago island (Cabo Verde)

Heliyon, Год журнала: 2023, Номер 9(4), С. e14651 - e14651

Опубликована: Март 21, 2023

Plants continue to constitute key elements of medical practice in West African countries. The Cabo Verde archipelago hosts a great diversity medicinal plants and local markets are considered important sites for trading harvested by rural communities. This study has two main goals: (i) assess the uses native species Santiago, biggest island archipelago, (ii) evaluate antioxidant, antimicrobial antidiabetic/antihyperglycemic activities trees (Tamarix senegalensis Sideroxylon marginatum) used traditional medicine traded markets. Our results revealed that on Santiago Island, 24 medicine. these (e.g., forage, timber, food fibres), their applications, plant parts used, mode administration conservation status presented here first time. Moreover, pharmacological characterization tree hydroethanolic extracts were richer phenolic compounds more active than aqueous counterparts. All studied significant antioxidant properties (DPPH FRAP assays) generally moderately against Gram-positive bacteria. inhibited carbohydrate digestive enzymes α-glucosidase α-amylase dose-dependent manner. For α-glucosidase, detected inhibitory activity (IC50 values from 2.0 ± 0.2 μg/mL 9.9 1.2 μg/mL) was significantly higher acarbose, suggesting both can delay glucose absorption, thereby assisting slowing down progression diabetes. findings highlight crucial importance have Verdean population, while also raising awareness need sustainable use flora, particular.

Язык: Английский

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A low-cost, antimicrobial aloe-alginate hydrogel film containing Australian First Nations remedy ‘lemon myrtle oil’ (Backhousia citriodora) – potential for incorporation into wound dressings

Heliyon, Год журнала: 2024, Номер 10(18), С. e37516 - e37516

Опубликована: Сен. 1, 2024

Язык: Английский

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Assessing the efficacy of polyvinyl alcohol/chitosan nanofibrous mat loaded with myrtle essential oil/gum Arabic in wound healing

Journal of Biomaterials Science Polymer Edition, Год журнала: 2025, Номер unknown, С. 1 - 22

Опубликована: Март 13, 2025

Nowadays, extensive research has been conducted on electrospun nanofibers for wound dressing applications. Considering the growing concern over bacterial resistance to common antibiotics, investigating potential of natural essential oils with antibacterial properties could prove be beneficial in addressing this issue. In response challenges posed by impaired healing, we have designed a novel polyvinyl alcohol/chitosan nanofiber embedded myrtle oil and gum Arabic dispersion (PVA/CS/MT-GA). The morphology molecular structure prepared were evaluated scanning electron microscopy (SEM) Fourier transform infrared (FTIR) analysis. synthesized PVA/CS/MT-GA composite demonstrated remarkable swelling capacity 744% exhibited acceptable mechanical strength. Additionally, water vapor transmission rate (WVTR) these was obtained as 2497 g.m−2.day−1, which falls within ideal range dressings. antimicrobial test results revealed that notable when tested against Escherichia coli Staphylococcus aureus. release profile MT from MT-containing burst mechanism nanofibers, can applications require an immediate therapeutic effect. Furthermore, dressings full-thickness model Wistar rats care damaged tissue promote faster healing times. Collectively, study suggest developed holds great promise candidate

Язык: Английский

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Retention and Antimicrobial Activity of Alginate-Encapsulated Bioactive Compounds from Leaves and Fruits of Myrtle (Myrtus communis L.)

Processes, Год журнала: 2025, Номер 13(4), С. 1220 - 1220

Опубликована: Апрель 17, 2025

Myrtle (Myrtus communis L.) is a rich source of bioactive compounds and nutraceuticals different polarities obtained from parts the plant, whose synergistic effect could be harnessed through formulation capsules. The aim this work was to investigate antimicrobial activity three myrtle formulations: essential oil aqueous leaf extract supercritical fruit extract, as well retention volatile, phenolic lipid in low-viscosity alginate capsules by electrostatic extrusion microencapsulation these formulations combined. At temperature 48 °C, 1.27% emulsifier 3% CaCl2, 72.86% volatiles, 61.13% phenolics 62.80% lipids were retained. All tested extracts showed good antibacterial activity, especially against Staphylococcus aureus Listeria monocytogenes, which most sensitive. An exceptionally high inhibitory achieved L. monocytogenes (35.25 mm) Escherichia coli (28 mm). Supercritical antifungal none lactic acid bacteria.

Язык: Английский

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