Cancers,
Год журнала:
2023,
Номер
15(10), С. 2758 - 2758
Опубликована: Май 14, 2023
Cancer
metastasis
is
a
significant
challenge
in
cancer
treatment,
and
most
existing
drugs
are
designed
to
inhibit
tumor
growth
but
often
ineffective
treating
metastatic
cancer,
which
the
leading
cause
of
cancer-related
deaths.
Resveratrol,
polyphenol
found
grapes,
berries,
peanuts,
has
shown
potential
preclinical
studies
as
an
anticancer
agent
suppress
metastasis.
However,
despite
positive
results
studies,
little
progress
been
made
clinical
trials.
To
develop
resveratrol
effective
agent,
it
crucial
understand
its
cellular
processes
signaling
pathways
This
review
article
evaluates
current
state
future
development
strategies
enhance
potency
against
within
therapeutic
dose.
In
addition,
we
critically
evaluate
animal
models
used
for
discuss
novel
techniques
accelerate
translation
from
bench
bedside.
The
appropriate
selection
vital
determining
whether
can
be
further
developed
antimetastatic
drug
therapy.
Oxidative Medicine and Cellular Longevity,
Год журнала:
2021,
Номер
2021(1)
Опубликована: Янв. 1, 2021
Emerging
evidence
revealed
the
significant
roles
of
heat
shock
factor
1
(HSF1)
in
cancer
initiation,
development,
and
progression,
but
there
is
no
pan-cancer
analysis
HSF1.
The
present
study
first
comprehensively
investigated
expression
profiles
prognostic
significance
HSF1
relationship
with
clinicopathological
parameters
immune
cell
infiltration
using
bioinformatic
techniques.
significantly
upregulated
various
common
cancers,
it
associated
prognosis.
Pan-cancer
Cox
regression
indicated
that
high
was
poor
overall
survival
(OS),
disease-specific
(DSS),
progression-free
interval
(PFI)
cervical
squamous
carcinoma
endocervical
adenocarcinoma
(CESC),
head
neck
(HNSC),
kidney
renal
papillary
(KIRP)
patients.
methylation
DNA
decreased
most
cancers
negatively
correlated
expression.
Increased
phosphorylation
S303,
S307,
S363
observed
some
cancers.
remarkably
levels
infiltrating
cells
checkpoint
genes.
Our
provides
a
deep
understanding
functions
oncogenesis
metastasis
different
Nature Communications,
Год журнала:
2023,
Номер
14(1)
Опубликована: Июнь 10, 2023
Faithful
inheritance
of
parental
histones
is
essential
to
maintain
epigenetic
information
and
cellular
identity
during
cell
division.
Parental
are
evenly
deposited
onto
the
replicating
DNA
sister
chromatids
in
a
process
dependent
on
MCM2
subunit
helicase.
However,
impact
aberrant
histone
partition
human
disease
such
as
cancer
largely
unknown.
In
this
study,
we
construct
model
impaired
by
introducing
MCM2-2A
mutation
(defective
binding)
MCF-7
breast
cells.
The
resulting
reprograms
modification
landscapes
progeny
cells,
especially
repressive
mark
H3K27me3.
Lower
H3K27me3
levels
derepress
expression
genes
associated
with
development,
proliferation,
epithelial
mesenchymal
transition.
These
changes
confer
fitness
advantages
some
newly
emerged
subclones
consequently
promote
tumor
growth
metastasis
after
orthotopic
implantation.
summary,
our
results
indicate
that
can
drive
progression.
Frontiers in Oncology,
Год журнала:
2022,
Номер
12
Опубликована: Сен. 15, 2022
Breast
cancer
remains
the
most
frequently
diagnosed
in
women
worldwide.
Delayed
presentation
of
disease,
late
stage
at
diagnosis,
limited
therapeutic
options,
metastasis,
and
relapse
are
major
factors
contributing
to
breast
mortality.
The
development
progression
is
a
complex
multi-step
process
that
incorporates
an
accumulation
several
genetic
epigenetic
alterations.
External
environmental
internal
cellular
microenvironmental
cues
influence
occurrence
these
alterations
drives
tumorigenesis.
Here,
we
discuss
state-of-the-art
information
on
epigenetics
how
risk
orchestrate
events,
emphasizing
necessity
for
multidisciplinary
approach
toward
better
understanding
gene-environment
interactions
implicated
cancer.
Since
modifications
reversible
susceptible
extrinsic
intrinsic
stimuli,
they
offer
potential
avenues
can
be
targeted
designing
robust
therapies.
Cancers,
Год журнала:
2023,
Номер
15(10), С. 2758 - 2758
Опубликована: Май 14, 2023
Cancer
metastasis
is
a
significant
challenge
in
cancer
treatment,
and
most
existing
drugs
are
designed
to
inhibit
tumor
growth
but
often
ineffective
treating
metastatic
cancer,
which
the
leading
cause
of
cancer-related
deaths.
Resveratrol,
polyphenol
found
grapes,
berries,
peanuts,
has
shown
potential
preclinical
studies
as
an
anticancer
agent
suppress
metastasis.
However,
despite
positive
results
studies,
little
progress
been
made
clinical
trials.
To
develop
resveratrol
effective
agent,
it
crucial
understand
its
cellular
processes
signaling
pathways
This
review
article
evaluates
current
state
future
development
strategies
enhance
potency
against
within
therapeutic
dose.
In
addition,
we
critically
evaluate
animal
models
used
for
discuss
novel
techniques
accelerate
translation
from
bench
bedside.
The
appropriate
selection
vital
determining
whether
can
be
further
developed
antimetastatic
drug
therapy.
