KDM4A-mediated histone demethylation of SLC7A11 inhibits cell ferroptosis in osteosarcoma

Biochemical and Biophysical Research Communications, Journal Year: 2021, Volume and Issue: 550, P. 77 - 83

Published: March 6, 2021

Language: Английский

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Pan‐Cancer Analysis of the Prognostic and Immunological Role of HSF1: A Potential Target for Survival and Immunotherapy

Oxidative Medicine and Cellular Longevity, Journal Year: 2021, Volume and Issue: 2021(1)

Published: Jan. 1, 2021

Emerging evidence revealed the significant roles of heat shock factor 1 (HSF1) in cancer initiation, development, and progression, but there is no pan-cancer analysis HSF1. The present study first comprehensively investigated expression profiles prognostic significance HSF1 relationship with clinicopathological parameters immune cell infiltration using bioinformatic techniques. significantly upregulated various common cancers, it associated prognosis. Pan-cancer Cox regression indicated that high was poor overall survival (OS), disease-specific (DSS), progression-free interval (PFI) cervical squamous carcinoma endocervical adenocarcinoma (CESC), head neck (HNSC), kidney renal papillary (KIRP) patients. methylation DNA decreased most cancers negatively correlated expression. Increased phosphorylation S303, S307, S363 observed some cancers. remarkably levels infiltrating cells checkpoint genes. Our provides a deep understanding functions oncogenesis metastasis different

Language: Английский

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Impaired histone inheritance promotes tumor progression

Nature Communications, Journal Year: 2023, Volume and Issue: 14(1)

Published: June 10, 2023

Faithful inheritance of parental histones is essential to maintain epigenetic information and cellular identity during cell division. Parental are evenly deposited onto the replicating DNA sister chromatids in a process dependent on MCM2 subunit helicase. However, impact aberrant histone partition human disease such as cancer largely unknown. In this study, we construct model impaired by introducing MCM2-2A mutation (defective binding) MCF-7 breast cells. The resulting reprograms modification landscapes progeny cells, especially repressive mark H3K27me3. Lower H3K27me3 levels derepress expression genes associated with development, proliferation, epithelial mesenchymal transition. These changes confer fitness advantages some newly emerged subclones consequently promote tumor growth metastasis after orthotopic implantation. summary, our results indicate that can drive progression.

Language: Английский

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Inhibitory Potential of Resveratrol in Cancer Metastasis: From Biology to Therapy

Cancers, Journal Year: 2023, Volume and Issue: 15(10), P. 2758 - 2758

Published: May 14, 2023

Cancer metastasis is a significant challenge in cancer treatment, and most existing drugs are designed to inhibit tumor growth but often ineffective treating metastatic cancer, which the leading cause of cancer-related deaths. Resveratrol, polyphenol found grapes, berries, peanuts, has shown potential preclinical studies as an anticancer agent suppress metastasis. However, despite positive results studies, little progress been made clinical trials. To develop resveratrol effective agent, it crucial understand its cellular processes signaling pathways This review article evaluates current state future development strategies enhance potency against within therapeutic dose. In addition, we critically evaluate animal models used for discuss novel techniques accelerate translation from bench bedside. The appropriate selection vital determining whether can be further developed antimetastatic drug therapy.

Language: Английский

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The evolutionary theory of cancer: challenges and potential solutions

Nature reviews. Cancer, Journal Year: 2024, Volume and Issue: 24(10), P. 718 - 733

Published: Sept. 10, 2024

Language: Английский

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