Biogenic metallic nanoparticles as game-changers in targeted cancer therapy: recent innovations and prospects

Future Journal of Pharmaceutical Sciences, Год журнала: 2024, Номер 10(1)

Опубликована: Фев. 22, 2024

Abstract Background Cancer is a significant global health issue, resulting from uncontrolled cell division leading to abnormal or tissue growth. Traditional chemotherapeutic techniques have investigated wide variety of pharmaceutically active molecules despite their poor bioavailability, quick renal clearance, inconsistent distribution, and unavoidable side effects. Green synthesis, unlike chemical methods, prioritizes eco-friendliness cost-effectiveness. Using natural sources like plant extracts, it minimizes environmental impact, reduces costs, aligns with sustainability goals. Operating under milder conditions, consumes less energy compared traditional approaches. synthesis highly promising efficient method for producing nanoparticles due its versatility scalability. Main body Nanotechnology making progress in cancer treatment because nanoparticles' tiny size, large surface area, adaptability, functionality, as well potential induce apoptotic pathways fast penetration internalization into cells. Biosynthesis metallic using microbe extracts attracting attention replace toxic chemicals phytochemicals that can act reducing, capping, stabilizing agents improve biocompatibility, antitumor, antioxidant properties. This review focuses on biosynthesized anticancer effects breast, prostate, skin, cervical, colorectal, lung, liver cancer. Conclusion therapy stands at the forefront innovative sustainable Despite challenges, ongoing research demonstrates biosynthesis revolutionize nanomedicine, emphasizing need continued exploration collaboration this rapidly advancing field. Overall, offers comprehensive understanding most recent developments future applications medicine.

Язык: Английский

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Biogenic metallic nanoparticles: from green synthesis to clinical translation

Naunyn-Schmiedeberg s Archives of Pharmacology, Год журнала: 2024, Номер 397(11), С. 8603 - 8631

Опубликована: Июнь 27, 2024

Язык: Английский

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Green biologically synthesized metal nanoparticles: biological applications, optimizations and future prospects

Future Science OA, Год журнала: 2024, Номер 10(1)

Опубликована: Март 11, 2024

In green biological synthesis, metal nanoparticles are produced by plants or microorganisms. Since it is ecologically friendly, economically viable and sustainable, this method preferable to other traditional ones. For their continuous groundbreaking advancements myriad physiochemical benefits, nanotechnologies have influenced various aspects of scientific fields. Metal (MNPs) the field anchor for outstanding optical, electrical chemical capabilities that outperform regular-sized counterparts. This review discusses most current biosynthesized synthesized organisms applications along with key elements involved in MNP synthesis. The displayed a manner will impart assertiveness, help researchers open questions, highlight many points conducting future research.

Язык: Английский

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Advances in the Optimization of Fe Nanoparticles: Unlocking Antifungal Properties for Biomedical Applications

Pharmaceutics, Год журнала: 2024, Номер 16(5), С. 645 - 645

Опубликована: Май 10, 2024

In recent years, nanotechnology has achieved a remarkable status in shaping the future of biological applications, especially combating fungal diseases. Owing to excellence nanotechnology, iron nanoparticles (Fe NPs) have gained enormous attention years. this review, we provided comprehensive overview Fe NPs covering key synthesis approaches and underlying working principles, factors that influence their properties, essential characterization techniques, optimization antifungal potential. addition, diverse kinds NP delivery platforms command highly effective release, with fewer toxic effects on patients, are great significance medical field. The issues biocompatibility, toxicity profiles, applications optimized field biomedicine also been described because these most significant determining inclusion clinical use. Besides this, difficulties regulations exist transition from laboratory experimental studies (toxicity, specific standards, safety concerns) NPs-based agents summarized.

Язык: Английский

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A review of microbes mediated biosynthesis of silver nanoparticles and their enhanced antimicrobial activities

Heliyon, Год журнала: 2024, Номер 10(11), С. e32333 - e32333

Опубликована: Июнь 1, 2024

In recent decades, biosynthesis of metal and (or) oxide nanoparticles using microbes is accepted as one the most sustainable, cost-effective, robust, green processes it does not encompass usage largely hazardous chemicals. Accordingly, numerous simple, inexpensive, environmentally friendly approaches for silver (AgNPs) were reported avoiding conventional (chemical) methods. This comprehensive review detailed an advance made in years microbes-mediated AgNPs evaluation their antimicrobial activities covering literature from 2015-till date. It also aimed at elaborating possible effect different phytochemicals, concentrations, extraction temperature, solvent, pH, reaction time, concentration precursor on shape, size, stability synthesized AgNPs. addition, while trying to understand against targeted pathogenic probable mechanism interaction produced with cell wall that led cell's reputed death have been detailed. Lastly, this shape size-dependent enhanced by synergetic known commercially available antibiotic drugs.

Язык: Английский

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Ephedra intermedia mediated synthesis of biogenic silver nanoparticles and their antimicrobial, cytotoxic and hemocompatability evaluations

Inorganic Chemistry Communications, Год журнала: 2022, Номер 137, С. 109252 - 109252

Опубликована: Янв. 24, 2022

Язык: Английский

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In Silico Strategies for Designing of Peptide Inhibitors of Oncogenic K-Ras G12V Mutant: Inhibiting Cancer Growth and Proliferation

Cancers, Год журнала: 2022, Номер 14(19), С. 4884 - 4884

Опубликована: Окт. 6, 2022

Ras plays a pivotal function in cell proliferation and is an important protein signal transduction pathways. Mutations genes encoding the drive signaling cascades essential for malignant transformation, tumour angiogenesis, metastasis are responsible above 30% of all human cancers. There evidence that

Язык: Английский

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Fabrication of colloidal silver-peptide nanocomposites for bacterial wound healing

Colloids and Surfaces A Physicochemical and Engineering Aspects, Год журнала: 2022, Номер 651, С. 129708 - 129708

Опубликована: Июль 17, 2022

Increased antibiotic resistance has become a real healthcare challenge for humanity. Several novel approaches the formation of nanomaterials have been developed to tackle different bacterial strains and wound disinfection. Short peptide modulated metal gained attention because their biocompatibility ability reduce ions in-situ form nanoparticles. Here we used short conjugate as reducing capping agent make stabilized silver-peptide composite nanoparticles under mild UV light exposure. This photochemical method is one green reduces toxic effects chemicals that are often in traditional synthetic strategies. These demonstrated promising activity against Escherichia coli Staphylococcus aureus at an in-vitro level cure wounds disinfections in-vivo. Furthermore, these show excellent biocompatibility, no side were observed liver enzymes organs, histopathology study. Such simple strategy sustainable supramolecular chemistry could help develop potential agents future.

Язык: Английский

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Microalgae as a potential natural source for the green synthesis of nanoparticles

Chemical Communications, Год журнала: 2024, Номер 60(29), С. 3874 - 3890

Опубликована: Янв. 1, 2024

The simple biofabrication of microalgae-assisted nanomaterials offers a versatile option with far-reaching implications, effectively addressing sustainability challenges, environmental pollution, biomedical and dynamic needs the society.

Язык: Английский

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The role of green synthesis metal and metal oxide nanoparticles in oral cancer therapy: a review

Journal of drug targeting, Год журнала: 2025, Номер unknown, С. 1 - 39

Опубликована: Янв. 30, 2025

There are 275,000 new cases of oral cancer (OC) per year, making it the sixth most common in world. Severe adverse effects, including loss function, deformity, and systemic toxicity, familiar with traditional therapies such as radiation, chemotherapy, surgery; due to their unique properties, nanoparticles (NPs) have emerged a superior alternative over chemo/radiotherapy surgery targeting capability, bioavailability, compatibility, high solubility. Due metallic NPs garnered significant attention OC control. In addition fact that metal may be harmful human cells, reactive chemicals used make them pose same risk, which limits use medicine. Green synthesis (GS) is novel strategy uses biological materials like yeast, bacteria, fungi, plant extracts. Compared more chemical processes, these environmentally benign manageable for living organisms. This article summarizes GS made metals oxides anticancer effects on OC. The method's potential benefits drawbacks advancing NPs' shaping therapy's future were also discussed.

Язык: Английский

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