Metal‐coordinated amino acid/peptide/protein‐based supramolecular self‐assembled nanomaterials for anticancer applications

Aggregate, Год журнала: 2024, Номер unknown

Опубликована: Окт. 3, 2024

Abstract Biomolecules with metals can form supramolecular nanomaterials through coordination assembly, opening new avenues for cancer theranostics and bringing unique insights into personalized nanomedicine. These biomaterials have been considered versatile innovative nanoagents due to their structure‒function control, biological nature, simple preparation methods. This review article summarized the recent developments in multicomponent formed from metal interactions amino acids, peptides, proteins, together anticancer drugs, theranostics. We discussed role of functional groups anchored building blocks interactions, subsequently, types were examined a perspective. Amino acids different drugs forming mechanisms highlighted. Peptides proteins used material formations, activity discussed. Ultimately, conclusion future outlook offer fundamental fabrication design precision medicine.

Язык: Английский

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Intestinal Toxicity of Metal Nanoparticles: Silver Nanoparticles Disorder the Intestinal Immune Microenvironment

ACS Applied Materials & Interfaces, Год журнала: 2023, Номер 15(23), С. 27774 - 27788

Опубликована: Июнь 6, 2023

Albeit numerous studies have been conducted on the toxicity evaluation of engineered metal nanoparticles (NPs), significant knowledge gaps remain regarding influence oral exposure to NPs intestine system, especially effects intestinal immune microenvironment. Herein, we examined long-term representative through and identified silver (Ag NPs) that resulted in severe damage. Oral Ag NP damaged epithelial structure, reduced thickness mucosal layer, altered microbiota. Particularly, layer increased phagocytosis by dendritic cells (DCs). Comprehensive animal vitro experiments unraveled directly interacted with DCs, resulting abnormal activation DCs generating reactive oxygen species inducing uncontrolled apoptosis. Furthermore, our data unveiled interactions between proportion CD103+CD11b+ induced Th17 cell inhibition regulatory T-cell differentiation, disordered microenvironment intestine. Collectively, these results represent a new point view cytotoxicity system. This study provides additional insights into health risks NPs, NPs.

Язык: Английский

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Amyloid-Inspired Engineered Multidomain Amphiphilic Injectable Peptide Hydrogel─An Excellent Antibacterial, Angiogenic, and Biocompatible Wound Healing Material

ACS Applied Materials & Interfaces, Год журнала: 2023, Номер 15(28), С. 33457 - 33479

Опубликована: Июль 10, 2023

The ingrained mechanical robustness of amyloids in association with their fine-tunable physicochemical properties results the rational design and synthesis tailor-made biomaterials for specific applications. However, incredible antimicrobial efficacy these ensembles has largely been overlooked. This research work provides an insight into interplay between self-assembly activity amyloid-derived peptide amphiphiles thereby establishes a newfangled principle toward development potent materials superior wound healing efficacy. Apart from relationship many neurodegenerative diseases, are now considered as important cornerstone our innate immune response against pathogenic microbes. Impelled by this observation, class amphiphilic peptide-based biomaterial designed taking Aβ42 template. AMP due to its amphipathic nature undergoes rapid form biocompatible supramolecular hydrogel network having significant antibacterial well effectivity on both Gram-negative P. aeruginosa MRSA-infected diabetic wounds via reduced inflammatory enhanced angiogenesis. Results suggest that disease-forming can be used blueprint fabrication biomaterial-based therapeutics fine-tuning hydrophobicity β-aggregation prone zone membrane interacting cationic residues.

Язык: Английский

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IN VITRO STUDY OF CYTOTOXICITY OF CADMIUM SULFIDE QUANTUM DOTS IN AQUEOUS SOLUTIONS

Colloids and Surfaces A Physicochemical and Engineering Aspects, Год журнала: 2025, Номер unknown, С. 136243 - 136243

Опубликована: Янв. 1, 2025

Язык: Английский

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Phytochemical-Mediated Green Synthesis of Silver, Copper, and Ag–Cu Bimetallic Nanoparticles Using Peganum harmala Demonstrating Advanced Catalytic, Antioxidant, and Biomedical Applications

Applied Biochemistry and Biotechnology, Год журнала: 2025, Номер unknown

Опубликована: Фев. 18, 2025

Язык: Английский

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Nanocoated Wound Healing Materials

Опубликована: Март 4, 2025

Язык: Английский

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Design of Short Peptides for the Reduction of Silver Ions and Stabilization of Nanocomposites in Combating Bacterial Infections

ChemBioChem, Год журнала: 2025, Номер unknown

Опубликована: Апрель 4, 2025

Combating bacterial infections has become a formidable challenge in healthcare due to the rise of antibiotic resistance. Recently, short peptide-based nanobiomaterials, assembled through silver metal and peptide building blocks, have emerged as promising agents for treating resistant infections. In this minireview, recent advances silver-peptide nanocomposites are highlighted, both with without assistance UV or sunlight, antibacterial applications. The chemical design biomolecules such amphiphilic peptides, amino acids, oligopeptides plays crucial role reduction, stabilization, biocompatibility nanocomposites. Noncovalent interactions involved formation explored context structure-function relationship. activities underlying mechanisms, which depend on specific also reviewed. Finally, conclusion outlook provide insights into novel blocks development enhanced activities.

Язык: Английский

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Engineering of self-assembled silver-peptide colloidal nanohybrids with enhanced biocompatibility and antibacterial activity

Scientific Reports, Год журнала: 2024, Номер 14(1)

Опубликована: Ноя. 2, 2024

Several bacterial strains have developed resistance against commercial antibiotics, and interestingly, supramolecular nanomaterials shown considerable advantages for antibacterial applications. However, the main challenges in adopting nanotechnology studies are random aggregation, compromised toxicity, multi-step preparation approaches, unclear structure-function properties. Herein, we designed amphiphilic tripeptide that acts as a reducing capping agent silver metal to form silver-peptide colloidal nanohybrids with mild assistance of UV light (254 nm) through photochemical reduction method. The characterized by different spectroscopic microscopic techniques, non-covalent molecular interactions between peptide building blocks confirm their central role formation nanohybrids. is biocompatible can reduce toxicity ions (Ag+) Ag0. These showed activity gram-negative gram-positive strains, possible mechanism killing cells could be membrane disruption. This synthetic strategy facile green, which helps avoid using toxic chemicals or reagents complicated methods nanohybrid biomedical

Язык: Английский

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Lipidomic Profiling and Pharmacological Activities of Ficus drupacea Oil: Comparative Study Between Conventional vs. Green Solvent

Chemistry & Biodiversity, Год журнала: 2024, Номер 21(4)

Опубликована: Фев. 27, 2024

Ficus drupacea is a medicinal tree found in temperate regions. Various parts of this plant had been used traditionally for the treatment various ailments such as root powder applied externally skin infections. Analysis was carried out on bioactive lipids extracted from fruit using both petroleum-based solvent (Hexane) and an environmentally friendly Dimethyl carbonate (DMC). The results showed that DMC extraction yielded high oil content (6.51 %). When examining fatty acid composition GC-FID analysis, with contained significant proportions essential acids linoleic (32.317 %), oleic (20.946 palmitic (25.841 etc. Additionally, resulted higher levels total phenolics compared to hexane. Moreover, exhibited stronger antioxidant properties, radical scavenging, anti- arthritic, photoprotective activity while displayed similar anti-inflammatory anti-microbial hexane-extracted oil. In summary, these findings demonstrate efficient safer alternative conventional hexane extracting oils fruit. It rich compounds human nutrition, including polyunsaturated acids, flavonoids, phenolic compounds, enhanced biological activities.

Язык: Английский

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Development of eugenol loaded cellulose-chitosan based hydrogels; in-vitro and in-vivo evaluation for wound healing

Colloids and Surfaces A Physicochemical and Engineering Aspects, Год журнала: 2024, Номер 693, С. 134033 - 134033

Опубликована: Апрель 21, 2024

Язык: Английский

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