LncRNA SNHG25 Promotes Glioma Progression Through Activating MAPK Signaling DOI
Zeyu Wu, Peng Lun,

Tao Ji

и другие.

Molecular Neurobiology, Год журнала: 2022, Номер 59(11), С. 6993 - 7005

Опубликована: Сен. 7, 2022

Язык: Английский

Identification and Validation of Cuproptosis-Related LncRNA Signatures in the Prognosis and Immunotherapy of Clear Cell Renal Cell Carcinoma Using Machine Learning DOI Creative Commons
Zhixun Bai, Jing Lu,

Anjian Chen

и другие.

Biomolecules, Год журнала: 2022, Номер 12(12), С. 1890 - 1890

Опубликована: Дек. 16, 2022

(1) Objective: We aimed to mine cuproptosis-related LncRNAs with prognostic value and construct a corresponding model using machine learning. External validation of the was performed in ICGC database multiple renal cancer cell lines via qPCR. (2) Methods: TCGA cohorts related clear carcinoma were included. GO KEGG analyses conducted determine biological significance differentially expressed (CRLRs). Machine learning (LASSO), Kaplan–Meier, Cox genes. The tumor microenvironment mutation load further studied. TIDE IC50 used evaluate response immunotherapy, risk cuproptosis genes established, ability this verified an external independent cohort. identified normal HK-2 cells four (3) Results: obtained 280 CRLRs 66 included TCGA-KIRC Then, three hub (AC026401.3, FOXD2−AS1, LASTR), which over-expressed ccRCC compared human cortex proximal tubule epithelial line HK-2, identified. In database, expression FOXD2-AS1 LASTR consistent qPCR TCGA-KIRC. results also indicated that patients low-risk ccRCC—stratified by tumor-node metastasis stage, sex, grade—had significantly better overall survival than those high-risk ccRCC. predictive algorithm showed that, according CRLR models, group more sensitive nine target drugs (A.443654, A.770041, ABT.888, AG.014699, AMG.706, ATRA, AP.24534, axitinib, AZ628), based on estimated half-maximal inhibitory concentrations. contrast, ABT.263 AKT inhibitors VIII AS601245. Using correlation between immune immunotherapy revealed are likely respond patients. terms marker levels, there significant differences high- groups. A high TMB score associated worse survival, could be factor for KIRC. (4) Conclusions: This study elucidates core LncRNAs, AC026401.3, LASTR, potential value, immunotherapeutic strategy, outcome

Язык: Английский

Процитировано

12

Epigenetic regulation of cutaneous T-cell lymphoma is mediated by dysregulated lncRNA MALAT1 through modulation of tumor microenvironment DOI Creative Commons
Wei Guo, Guang‐Ming Liu,

Ji-Yu Guan

и другие.

Frontiers in Oncology, Год журнала: 2022, Номер 12

Опубликована: Авг. 17, 2022

Cutaneous T-Cell Lymphoma (CTCL) is a rare non-Hodgkin lymphoma marked by migration of T-lymphocytes to the skin. It has many subtypes some which are aggressive with documented metastasis. We investigated possible role lncRNA MALAT1 in CTCL cells because its involvement cancer A screening patients revealed elevated levels patients, compared healthy individuals. For our investigation, we employed HH and H9 silenced understand mediated functions. Such silencing resulted reversal EMT inhibition stem cell phenotype, along reduced growth proliferation. was established through increased E-cadherin N-cadherin while phenotype evident Sox2 Nanog. had higher circulating IL-6, IL-8, IL-10, TGFβ, PGE2 MMP7 factors released tumor-associated macrophages tumor microenvironment. sponged miR-124 as this suppressive miRNA de-repressed upon silencing. Moreover, downregulation attenuated effects. Our study provides rationale for further studies focused on an evaluation MALAT1-miR-124 progression.

Язык: Английский

Процитировано

10

Long non-coding RNAs play an important regulatory role in tumorigenesis and tumor progression through aerobic glycolysis DOI Creative Commons

Ni Fan,

Hui Fu,

Xuchen Feng

и другие.

Frontiers in Molecular Biosciences, Год журнала: 2022, Номер 9

Опубликована: Авг. 22, 2022

Compared to normal cells, cancer cells generate ATP mainly through aerobic glycolysis, which promotes tumorigenesis and tumor progression. Long non-coding RNAs (LncRNAs) are a class of transcripts longer than 200 nucleotides with little or without evident protein-encoding function. LncRNAs involved in the ten hallmarks cancer, interestingly, they also closely associated glycolysis. However, mechanism this process is non-transparent date. Demonstrating lncRNAs regulating progression glycolysis particularly critical for therapy, may provide novel therapeutic targets strategies treatment. In review, we discuss role progression, further explore their interaction, hope target

Язык: Английский

Процитировано

9

A novel lncRNA FPASL regulates fibroblast proliferation via the PI3K/AKT and MAPK signaling pathways in hypertrophic scar DOI Creative Commons

Fang Ma,

Jiangyong Shen,

Hui Zhang

и другие.

Acta Biochimica et Biophysica Sinica, Год журнала: 2022, Номер unknown

Опубликована: Авг. 29, 2022

Hypertrophic scar is a problem for numerous patients, especially after burns, and characterized by increased fibroblast proliferation collagen deposition. Increasing evidence demonstrates that lncRNAs contribute to the development progression of various diseases. However, function in hypertrophic formation remains poorly characterized. In this study, novel proliferation-associated lncRNA, named lncRNA FPASL (MSTRG.389905.1), which mainly localized cytoplasm, found be downregulated scar, as detected microarray qRT-PCR. The full-length further investigation confirms it has no protein-coding potential. knockdown fibroblasts triggers proliferation, whereas overexpression directly attenuates fibroblasts. Furthermore, target genes differentially expressed scars matched adjacent normal tissues are enriched signaling pathways, including PI3K/AKT MAPK determined GO annotation KEGG enrichment analysis. We also demonstrate activates specific inhibitors pathways can reverse promoted knockdown. Our findings better understanding role suggest may act potential therapeutic scar.

Язык: Английский

Процитировано

9

LncRNA SNHG25 Promotes Glioma Progression Through Activating MAPK Signaling DOI
Zeyu Wu, Peng Lun,

Tao Ji

и другие.

Molecular Neurobiology, Год журнала: 2022, Номер 59(11), С. 6993 - 7005

Опубликована: Сен. 7, 2022

Язык: Английский

Процитировано

9